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  • 1
    Electronic Resource
    Electronic Resource
    Mixed monolayers and cast films of acyl ester and acylamino phospholipids (1992)
    s.l. : American Chemical Society
    Langmuir 8 (1992), S. 2479-2485 
    Details
    ISSN: 1520-5827
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/la00046a021
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  • 2
    Electronic Resource
    Electronic Resource
    Modulatory effect of bucillamine (SA96) on interleukin-1-and/or-2-induced proliferation of T lymphocytes (1990)
    Springer
    Inflammation research 31 (1990), S. 285-289 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Bucillamine [SA96: N-(2-mercapto-2-methylpropanoyl)-l-cysteine], a synthetic SH compound, has recently been developed as remission-inducing agent for rheumatoid arthritis (RA), and its clinical usefulness for RA has been proved in Japan. Bucillamine suppressed the mitogen-induced proliferation of murine lymphocytesin vitro. The present study was undertaken to clarify the effect of bucillamine primarily on the release of interleukin (IL)-1 from monocytes and on the proliferation of T cells. Bucillamine significantly inhibited IL-1-induced thymocyte proliferation in a dose-dependent manner. And, bucillamine also inhibited IL-2-induced proliferation at the concentration of 1×10−4 M, but augmented proliferation at the concentration of 1×10−5 M. In contrast,d-penicillamine (an analogous SH compound to bucillamine) did not show any significant effect at similar concentrations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01997621
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  • 3
    Electronic Resource
    Electronic Resource
    Adaptation of solitary corals and their zooxanthellae to low light and UV radiation (1993)
    Springer
    Marine biology 117 (1993), S. 685-691 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Adaptation of solitary corals, Fungia repanda and F. echinata, and their zooxanthellae to low light and ultraviolet light B (UV-B) was studied with respect to changes in their protein contents, photosynthetic pigment contents and the photosynthesis-irradiance (P-I) curves. The corals were collected from 1 to 50 m depths in the Republic of Belau (Paulau) in 1990 and 1991. The chlorophyll a content in a unit surface area of the coral did not change significantly with the depth of the habitat, whereas cellular chlorophyll a in the algae increased with the depth. Zooxanthellae density and protein content in a unit surface area of Fungia spp. decreased with the depth. Photosynthetic parameters normalized by a unit surface area of the Fungia spp., maximum gross photosynthetic rate (P gmax area-1) and dark respiration rate (R area-1), were negatively correlated with the depth, while initial slope of the P-I curve (α) did not show significant correlation with the depth. Compensation light intensity (Ic) decreased with the depth. In isolated zooxanthellae, P max chl a -1, and R chl a -1 decreased with the depth, while αchl a was constant. P gmax cell-1 and R cell-1 did not change significantly but αcell increased with the depth. Ic decreased with the depth as in the intact corals. Reduction of protein content in a unit area of the coral from deeper habitat implies decrease of host animal tissues. Reduction of Ic can be explained by decrease of R area-1, which may be due to the diminution of animal tissues. The photoadaptational response to low light intensity of intact Fungia spp. was found to be a combination of the photoadaptation of symbiotic algae and the decrease of host animal tissue. In order to study their adaptation to ultraviolet (UV) radiation, P-I curves of Fungia spp. and isolated zooxanthellae were analyzed before and after UV-B irradiation. 1 h UV-B irradiation showed no effect on the photosynthetic rate of the shallow water (1 m) corals, while it inhibited the photosynthesis of the deep water (30 m) corals and zooxanthellae isolated from both shallow and deep water corals. These results indicate that the host, Fungia spp., in shallow water have protective mechanism for intense UV-B in their habitat. These photoadaptational mechanisms seem to allow the Fungia spp. to have wide vertical distribution where light intensity spans more than two orders of magnitude.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00349781
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  • 4
    Electronic Resource
    Electronic Resource
    Delayed disposition of adriamycin and its active metabolite in haemodialysis patients (1993)
    Springer
    European journal of clinical pharmacology 44 (1993), S. 301-302 
    Details
    ISSN: 1432-1041
    Keywords: Adriamycin ; Haemodialysis ; adriamycinol ; pharmacokinetics ; moment analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00271378
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  • 5
    Electronic Resource
    Electronic Resource
    Monoclonal antibody HML-1 reactivity with adult T-cell leukaemia/lymphoma and other lymphomas (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 25 (1994), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Human T-cell leukaemia/lymphoma virus type 1 (HTLV-1), a causative virus of adult T-cell leukaemia/lymphoma (ATLL), is known to be transmitted by breast-feeding. Using a monoclonal antibody HML-1 which labels human intestinal intra-epithelial T lymphocytes, we have immunohistochemically examined ATLL tissues in order to evaluate the possibility that HTLV-1 infected intestinal T cells are the origin of ATLL cells. Previously this antibody was reported to react with intestinal T-cell malignant lymphomas but not with peripheral tumours, or any B-cell lymphomas. We investigated 181 patients with malignant lymphomas and found that 19 out of 113 ATLLs were positive for HML-1. T-cell malignant lymphomas excluding ATLL also reacted with HML-1 (7/24), but all the B-cell lymphomas 0/33) and non-neoplastic lymph node and skin lesions (0/10) were negative for HML-1. In patients with ATLL and other T-cell malignant lymphomas, the positivity level of HML-1 was relatively higher in stomach (3/7) and tonsil (2/6) than that in lymph nodes (15/100) and skin (8/47). We observed one HML-1 positive ATLL patient with tumour formation in the skin and lymphadenopathy and marked infiltration of the large intestine but minimal involvement of other organs. Although HML-1 was frequently expressed in gastric infiltration of ATLL, the level of positivity was too low in lymph nodes to support the hypothesis that HTLV-1 infected intestinal T cells are the origin of ATLL cells. Some of the HML-1 positive ATLL cases co-expressed CD30. Furthermore, three of six cases of Ki-1 lymphoma (large anaplastic cell lymphoma) were positive for HML-1. We conclude that expression of HML-1 in ATLL reflects an activated state of the lymphoma cells, but not the intestinal origin of ATLL cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1994.tb01322.x
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  • 6
    Electronic Resource
    Electronic Resource
    STATISTICAL INVESTIGATION OF THE BEHAVIOUR OF MICROCRACKS IN CARBON STEELS (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Fatigue & fracture of engineering materials & structures 14 (1991), S. 0 
    Details
    ISSN: 1460-2695
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract— In order to clarify the statistical behaviour of microcracks, rotating bending fatigue tests of plain specimens were carried out using two kinds of carbon steel with different microstructures, normalized 0.21% C steel and heat-treated 0.45% C steel. The emphasis is to investigate separately the statistical properties of the initiation and propagation of microcracks through successive observations of the specimen surface. Results show that the microcrack initiation life distributions of normalized and heat-treated steels are expressed by a two-parameter Weibull distribution and a Weibull distribution of the mixed type, respectively. On the other hand, the microcrack propagation life distributions of these steels are represented by three-and two-parameter Weibull distributions, respectively. The three-parameter Weibull distribution is well fitted to the crack length distribution for both the steels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-2695.1991.tb00715.x
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  • 7
    Electronic Resource
    Electronic Resource
    CRACK INITIATION AND PROPAGATION BEHAVIOUR OF A HEAT-TREATED CARBON STEEL IN CORROSION FATIGUE (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Fatigue & fracture of engineering materials & structures 15 (1992), S. 0 
    Details
    ISSN: 1460-2695
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract— When estimating fatigue damage quantitatively it is important to clarify its physical basis. In this study, rotating bending fatigue tests of a heat-treated 0.45% carbon steel were carried out in 3% NaCl solution, in order to clarify the physical basis of corrosion fatigue damage from successive observations of plastic replicas. The results show that corrosion pits are generated during the early stages of cycling, then most of them grow with further cycling until a crack is initiated from each corrosion pit. The initiation of corrosion pits from slip bands is observed only in the case when the stress range is relatively large, and in the range of stress for which slip bands are produced in air. After initiation of a crack, the crack propagates by frequent interactions and coalescence with other cracks. The growth rate of an especially small crack in NaCl solution is larger than that in air. However, the growth rate of a comparatively large crack is smaller in NaCl solution than in air.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-2695.1992.tb01277.x
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  • 8
    Electronic Resource
    Electronic Resource
    SCATTER CHARACTERISTICS OF FATIGUE LIFE AND THE BEHAVIOUR OF SMALL CRACKS (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Fatigue & fracture of engineering materials & structures 15 (1992), S. 0 
    Details
    ISSN: 1460-2695
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Usually, there is large scatter in fatigue data and this should be evaluated quantitatively when fatigue data are applied to the design of machines and structures. Consequently it is important to clarify the physical basis of scatter in fatigue life. In this present study, rotary bending fatigue tests were performed on an annealed 0.21% carbon steel. At least sixteen smooth specimens were fatigued at each of three stress ranges and successive observations of the surface were studied for all the specimens using the plastic replica method. By examining the initiation and propagation behaviour of cracks the physical basis of scatter in fatigue life is analysed and discussed. To estimate the scatter characteristics quantitatively, the distributions of crack initiation life, propagation life, fatigue life and crack length were individually studied by assuming a Weibull distribution for each set of data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-2695.1992.tb00024.x
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  • 9
    Electronic Resource
    Electronic Resource
    STATISTICAL INVESTIGATION OF THE BEHAVIOUR OF SMALL CRACKS AND FATIGUE LIFE IN CARBON STEELS WITH DIFFERENT FERRITE GRAIN SIZES (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Fatigue & fracture of engineering materials & structures 17 (1994), S. 0 
    Details
    ISSN: 1460-2695
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract— In order to study the relation between the scatter characteristics of small crack growth behaviour and fatigue life, rotatory bending fatigue tests of smooth specimens were carried out using 0.21% carbon steels of different ferrite grain sizes. Fifteen to eighteen specimens were fatigued at each stress amplitude, and the initiation and propagation behaviour of the cracks which led to the final fractures were examined for all the specimens. The physical basis of scatter in fatigue life was investigated, based on the successive observation of fatigue damage on the surface using the plastic replica technique, followed by an analysis of the data assuming a Weibull distribution. A statistical investigation of the physical basis of scatter in relation to the ferrite grain size was performed, i.e. the distributions for crack initiation life, crack propagation life, fatigue life and growth rate of small cracks. Finally, the fluctuation of crack growth rate was studied in relation to the application of a crack growth law for microstructurally small cracks.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-2695.1994.tb00262.x
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  • 10
    Electronic Resource
    Electronic Resource
    FATIGUE LIFE PREDICTION OF HEAT-TREATED CARBON STEELS AND LOW ALLOY STEELS BASED ON A SMALL CRACK GROWTH LAW (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Fatigue & fracture of engineering materials & structures 17 (1994), S. 0 
    Details
    ISSN: 1460-2695
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract— Since heat-treated high strength steels are often used as materials for machines and structures that operate under severe service conditions, it is important to evaluate their fatigue life. Hence the growth law of a small fatigue crack must be known in order to estimate the fatigue life of machines and structures since the life of such members is controlled mainly by the behaviour of a small crack. The growth rate of a small crack can not be predicted usually by linear elastic fracture mechanics, but can be determined uniquely by the term σnal, where σa is stress amplitude, l is crack length and n is a material constant. In this paper, the small-crack growth law of heat-treated carbon steels and low alloy steels was studied. An effective and convenient method based on a small-crack growth law, dl/dN=C3(σa/σa)nl is proposed, where σu is the ultimate tensile strength, for predicting the small crack propagation life of heat- treated steels with different tensile strength levels, together with a method for determining the fatigue life of plain members.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-2695.1994.tb00799.x
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