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  • 1
    Electronic Resource
    Electronic Resource
    Growth and Characterization of GaAs Films from Tris(di-tert-butylarsino)gallane (1994)
    s.l. : American Chemical Society
    Chemistry of materials 6 (1994), S. 871-874 
    Details
    ISSN: 1520-5002
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/cm00042a028
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  • 2
    Electronic Resource
    Electronic Resource
    Genetic Analysis of Resistance to Phytophthora Root Rot in Tomato (Lycopersicon esculentum Mill.) (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Plant breeding 106 (1991), S. 0 
    Details
    ISSN: 1439-0523
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: The resistant accession, LA1312, and the susceptible cultivar ‘Peto 343′, were crossed to develop F1, F2 and BC1 populations for genetic analysis of resistance in tomatoes to Phytophthora parasitica Dastur, the causal agent of Phytophthora root rot. There was no maternal effect on resistance. Generation means analysis indicated that tolerance to Phytophthora root rot was under genetic control with both simple (additive and dominance) and digenic interaction (additive × additive and additive × dominance) effects contributing to the total genetic variation among generation means. Weighted least square regression analysis indicated that the majority (ca. 96 %) of the genetic variation could be explained by simple additive effects alone. Narrow sense heritability was estimated as 0.22. Based on effective factor formulae, at least five effective factors controlled the resistance. Implications for breeding procedures are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1439-0523.1991.tb00475.x
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  • 3
    Electronic Resource
    Electronic Resource
    Determination of the concentration profile at the surface of deuterated polystyrene/hydrogenated polystyrene blends using high-resolution ion scattering techniques (1991)
    s.l. : American Chemical Society
    Macromolecules 24 (1991), S. 5991-5996 
    Details
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ma00022a014
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  • 4
    Electronic Resource
    Electronic Resource
    Synthesis and structure of the first base-free diphosphadigalletane (1991)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 113 (1991), S. 7050-7052 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00018a061
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  • 5
    Electronic Resource
    Electronic Resource
    The MHC Class I Associated Beta2-microglobulin (β2m) Light Chain is Expressed in a Molar Excess Over HLA-ABC and CD1 on the Membrane of Leukaemic B Cells but not Leukaemic T Cells: Evidence for Further β2m-Associated Molecules (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 34 (1991), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Beta2-microglobulin (β2m) constitutes the common light chain of both the MHC-encoded HLA-ABC molecules and a group of structurally related glycoproteins recognized by antibodies of the first cluster of differentiation (CD1a, CD1b and CD1c). These CD1 antigens appear similar to murine T1 and Qa molecules in terms of structure and tissue distribution, although the question of inter-species homology is controversial. A further group of alloantigens expressed predominantly on T cells has been reported however, with immunogenetic characteristics more closely analogous to the murine T1/Qa system than the CD1 antigens, although their precise identity remains ill-defined. Having previously shown that malignant B cells may express membrane CD1c, we examined leukaemic B-cells corresponding to early lymphoblastic differentiation (null-and common acute lymphoblastic leukaemia) through to the terminal plasma cell stage for the expression of other non-HLA class I β2m -associated molecules. It was found that leukaemic B-cells at intermediate/late stages of differentiation, represented by non-Hodgkin's lymphoma (B-NHL) and‘hairy-cell’leukaemia (HCL), had significantly higher β2m: HLA-ABC ratios than did the cells from other types of B-cell malignancy. Although leukaemic B cells with a demonstrable non HLA-ABC- associated β2m component expressed detectable levels of CD1c. and insignificant levels of CD 1a and CD 1b, the antigen density was insufficient to account for the excess β2m. In vitro stimulation of leukaemic B cells by phorbol ester substantially increased the expression of HLA-ABC and CD1c, but also accentuated further the difference between the expression of these molecules and that of β2m. There was no detectable β2m other than that associated with HLA-ABC and CD1 on the surface of malignant T cells by contrast. Our findings strongly support the existence, at certain stages of leukaemic B-cell differentiation, of an additional β2m component(s) other than that associated with HLA-ABC and CD1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1991.tb01520.x
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  • 6
    Electronic Resource
    Electronic Resource
    Has modern management improved the outcome of infants with intracranial tumours? (1990)
    Springer
    Child's nervous system 6 (1990), S. 327-330 
    Details
    ISSN: 1433-0350
    Keywords: Infancy ; Intracranial tumour ; CT scan ; Radiotherapy ; Chemotherapy ; Long-term outcome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Records of 92 children were reviewed who, in the first 18 months of life had an intracranial tumour, and who were registered with the Manchester Children's Tumour Registry during the 34-year period from 1953 to 1987. The incidence of intracranial tumour was 1 in 25000 live births, and 85% of the tumours were malignant. The introduction of computed tomography (CT) in the region in 1976 improved the diagnostic accuracy and led to early diagnosis. This also coincided with refined radiotherapy and improved chemotherapy. The surgical attitude became more aggressive, and with early treatment, mortality was reduced, though the 1-month operative mortality still remains high at 15%. All survivors were available for follow-up. All children with axial tumours died within 9 years. Long-term follow-up did not suggest significant improvement in the overall survival or in the quality of life, though there was a significant improvement in the 5-year survival rate with modern management.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00298278
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  • 7
    Electronic Resource
    Electronic Resource
    Intracranial tumours in the first 18 months of life (1990)
    Springer
    Child's nervous system 6 (1990), S. 371-374 
    Details
    ISSN: 1433-0350
    Keywords: Infancy ; Intracranial tumour ; Hereditary factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract There are few population-based studies of intracranial tumours in children. This study examines 93 brain tumours in children up to 18 months of age from over 800 childhood central nervous system tumours reported to the Manchester Children's Tumour Registry during the period 1953–1987. The incidence was 1 per 25 000 live births. Of these tumours, 85% were malignant. The three most common tumours were medulloblastoma, ependymoma and juvenile astrocytoma. Eighteen percent of the tumours were in the axial region. Twenty-five percent were connected to the ventricles. The tumour was supratentorial in two-thirds of the children under 6 months of age. A high incidence of tumours in the families of these children was found; tumours were noted in two sets of siblings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00302220
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  • 8
    Electronic Resource
    Electronic Resource
    Genetic analysis of salt tolerance during germination in Lycopersicon (1991)
    Springer
    Theoretical and applied genetics 81 (1991), S. 321-326 
    Details
    ISSN: 1432-2242
    Keywords: Lycopersicon esculentum ; Salt tolerance ; Seed germination ; Maternal effects ; Tomato improvement ; Gene action
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The salt-tolerant cultivated tomato (Lycopersicon esculentum) accession, ‘PI174263’, and a sensitive cv, ‘UCT5’, were crossed to develop reciprocal F1, F2 and BC1 populations for genetic analysis of salt tolerance in tomatoes during seed germination. Variation was partitioned into embryo, endosperm and maternal (testa and cytoplasmic) components. Generation means analysis indicated that there were no significant embryo (additive, dominance or epistatic) effects on germination performance under salt stress. Highly significant endosperm additive and testa dominance effects were detected. The proportion of the total variance explained by the model containing these two components was R2=98.2%. Variance component analysis indicated a large genetic variance with additive gene action as the predominant component. Furhter inspection indicated that this variance was attributable to endosperm additive effects on germinability under salt stress. Narrow-sense heritability was estimated as moderately high. Implications for breeding procedures are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00228671
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  • 9
    Electronic Resource
    Electronic Resource
    Models to estimate maternally controlled genetic variation in quantitative seed characters (1992)
    Springer
    Theoretical and applied genetics 83 (1992), S. 360-366 
    Details
    ISSN: 1432-2242
    Keywords: Additive genetic variance ; Dominance genetic variance ; Maternal effects ; Generation means analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Estimating quantitative contributions to specific traits can be accomplished from a variety of genetic models (Mather 1949; Mather and Jinks 1971; Falconer 1981). Residual genetic effects, those beyond main and interaction effects of the embryo genotype, are often pooled under a single classification, termed maternal effects. Maternal contributions to seed-related traits can originate from various maternal sources (e.g., endosperm, testa and cytoplasm). Quantitative contributions of a maternal nature are not predictable from parental performance and effects are largely non-persistent over generations (Jinks et al. 1972). The methods used to determine maternal effects in quantitative traits often do not measure quantitative genetic parameters, while those that do are either complex or partially resolve potential contributions of individual sources of maternal effects. We present simple genetic models for estimating quantitative genetic parameters which take into account maternal effects expressed in the major seed tissues of higher plants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00224283
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  • 10
    Electronic Resource
    Electronic Resource
    Mapping salt-tolerance genes in tomato (Lycopersicon esculentum) using trait-based marker analysis (1993)
    Springer
    Theoretical and applied genetics 87 (1993), S. 184-192 
    Details
    ISSN: 1432-2242
    Keywords: Tomato ; Salt tolerance ; Seed germination ; Isozyme markers ; QTL mapping
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The germination responsiveness of an F2 population derived from the cross Lycopersicon esculentum (UCT5) x L. pennellii (LA716) was evaluated for salt tolerance at two stress levels, 150 mM NaCl + 15 mM CaCl2 and 200 mM NaCl + 20 mM CaCl2. Individuals were selected at both tails of the response distribution. The salt-tolerant and salt-sensitive individuals were genotyped at 16 isozyme loci located on 9 of the 12 tomato chromosomes. In addition, an unselected (control) F2 population was genotyped at the same marker loci, and gene frequencies were estimated in both selected and unselected populations. Trait-based marker analysis was effective in identifying genomic locations (quantitative trait loci, QTLs) affecting salt tolerance in the tomato. Three genomic locations marked by Est-3 on chromosome 1, Prx-7 on chromosome 3, and 6Pgdh-2 and Pgi-1 on chromosome 12 showed significant positive effects, while 2 locations associated with Got-2 on chromosome 7 and Aps-2 on chromosome 8 showed significant negative effects. The identification of genomic locations with both positive and negative effects on this trait suggests the likelihood of recovering transgressive segregants in progeny derived from these parental lines. Similar genomic locations were identified when selection was made either for salt tolerance or salt sensitivity and at both salt-stress treatments. Comparable results were obtained in uni- and bidirectional selection experiments. However, when marker allele gene frequencies in a control population are unknown, bidirectional selection may be more efficient than unidirectional selection in identifying marker-QTL associations. Results from this study are discussed in relationship to the use of molecular markers in developing salt-tolerant tomatoes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00223763
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