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  • 1
    Electronic Resource
    Electronic Resource
    Relationships among expression, transcription and rearrangement of T-cell receptor Β gene in T-cell lymphomas (1990)
    Springer
    Virchows Archiv 417 (1990), S. 57-65 
    Details
    ISSN: 1432-2307
    Keywords: T-cell receptors ; Malignant lymphomas ; Immunohistochemistry ; Transcription ; Rearrangement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The expression of T-cell receptors (TCR) in malignant lymphomas was examined immunohistochemically by monoclonal antibodies which react with the TCRΒ or TCRδ chain. TCRΒ was expressed in 16 out of 47 non-Hodgkin's lymphomas. These included 15 T-cell lymphomas and 1 Ki-1 lymphoma. The anti-TCRΒ chain antibody,ΒF1, did not react with 26 B-cell lymphomas, 1 Ki-1 lymphoma or 6 Hodgkin's disease. The anti-TCRδ chain antibody, TCRδ1, did not react with any type of malignant lymphoma. Although TCRΒ and CD3 were co-expressed in normal lymphoid tissues and most T-cell lymphomas, 3 cases of CD3+CD4+ CD8−T-cell lymphoma failed to express TCR0. TCRΒ and Ig JH gene configurations in malignant lymphomas were examined by Southern hybridization. Although each of 9 T-cell lymphomas had a rearranged TCRΒ locus, TCRΒ gene rearrangement in the 3 cases ofΒF1−CD3+T-cell lymphomas was demonstrated by Southern blot. No transcripts of the TCRΒ gene could be found in 2 out of the 3ΒF1−CD3+T-cell lymphomas by Northern blot, indicating the lack of TCRΒ protein expression to be due to non-transcription of the TCR gene. Loss of TCRΒ proteins in these T-cell lymphomas is thus quite likely to be associated with T-cell tumour activation and progression, since 3ΒF1−CD3+T-cell lymphomas expressed CD25 (interleukin-2 receptor) to a high degree.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01600110
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  • 2
    Electronic Resource
    Electronic Resource
    Colocalization of growth hormone (GH) and glycoprotein subunit a in GH-producing pituitary adenomas in acromegalic patients (1994)
    Springer
    Acta neuropathologica 87 (1994), S. 568-571 
    Details
    ISSN: 1432-0533
    Keywords: KeyWordsAcromegaly ; Pituitary gland ; Growth hormone ; Gonadotropin α-subunit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Thirty-one consecutive cases of pituitary adenoma in acromegalic patients were studied by immunohistochemistry. All adenomas contained cells immunoreactive with the anti-α-subunit of gonadotropic hormones (α; 0.6 – 53   % of tumor cells) as well as with anti-growth hormone (GH; 4 – 74   % of tumor cells). In serial section study, most cells immunoreactive with anti-α were identical to cells immunoreactive with anti-GH. There was a positive correlation between the percentages of cells immunoreactive for α in GH cells [α(%)/GH(%)] and those for prolactin (PRL) in immunoreactive tumor cells ♪PRL(%)/[PRL(%)+GH(%)]♪ in mixed GH cell-PRL cell adenomas, suggesting that the α-subunit may play a role in emergence of PRL cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00293316
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Immunohistochemical analysis of 61 pituitary adenomas with a monoclonal antibody to the neuron-specific β-tubulin isotype (1993)
    Springer
    Acta neuropathologica 86 (1993), S. 518-520 
    Details
    ISSN: 1432-0533
    Keywords: Neuron-specific β-tubulin ; TUJ1 monoclonal antibody ; Pituitary gland ; Pituitary adenoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pituitary adenomas surgically resected from 61 consecutive patients and 9 normal pituitary glands were studied by immunohistochemistry to determine the localization of the class IIIβ-tubulin isotype (neuron-specific) which is recognized by the monoclonal antibody TUJ1. In normal pituitary glands only a few cells were weakly immunopositive for TUJ1, whereas, in 43(73%) of 61 adenomas, more than 5% of tumor cells were immunopositive. The result may indicate that this neuron-specific β-tubulin isotype may be either expressed de novo or enhanced under the transformation of pituitary acinar cells to tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00228589
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  • 4
    Electronic Resource
    Electronic Resource
    Sialosylated lewis x expression in CD30-positive anaplastic large-cell lymphomas (1992)
    Springer
    Journal of cancer research and clinical oncology 119 (1992), S. 87-90 
    Details
    ISSN: 1432-1335
    Keywords: Sialosylated Lewis x ; Anaplastic large-cell lymphoma ; Lymphoma with NK phenotype
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The expression of sialosylated Lewis x (SLEX), a ligand for endothelial leukocyte adhesion molecule 1 in malignant lymphomas, was immunohistochemically examined, using the monoclonal antibody, CSLEX1, which specifically reacts with SLEX. It was expressed in 6 out of 64 non-Hodgkin's lymphomas, which consisted of 1 nasal large-cell lymphoma and 5 of 8 (62%) Ki-1-positive anaplastic large-cell lymphomas (ALCL). One nasal lymphoma positive for SLEX co-expressed a T cell marker, cluster of differentiation (CD) 5, and natural killer (NK) cell markers such as CD56 and CD16, indicating that SLEX+ nasal lymphoma cells are possibly malignant counterparts of SLEX+ NK cells. SLEX did not react with 30 B cell lymphomas or most Hodgkin's disease lymphomas, though it did with one lymphocyte predominance type. Although SLEX+ ALCL exhibit T cell markers in some cases, some ALCL expressing SLEX may represent histiocytic differentiation of the neoplastic cells. The lymphoma cells of ALCL were preferentially positive for SLEX, in contrast to Hodgkin's disease cells, and thus CSLEX1 in conjunction, with CD30 and CD15 should be of use for analyzing and making differential diagnoses of routine paraffin-embedded sections of ALCL.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01209661
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  • 5
    Electronic Resource
    Electronic Resource
    Immunohistochemical examination of tumor-suppressor gene p53 product and pyrimidine dimer in solar keratosis (1993)
    Springer
    Journal of cancer research and clinical oncology 119 (1993), S. 260-262 
    Details
    ISSN: 1432-1335
    Keywords: p53 ; Pyrimidine dimer ; Immunohistochemistry ; Solar keratosis ; UV
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to find biomarkers to measure the effects of UV irradiation, we examined the accumulation of p53 protein and pyrimidine dimers in 18 solar keratosis specimens. Frozen or AMeX-fixed solar keratosis specimens were immunohistochemically stained by anti-p53 mouse monoclonal antibody, pAb1801 and polyclonal anti-(pyrimidine dimer) antibody. Nuclear accumulation of p53 protein was found in 5/18 (28%) solar keratosis lesions. The percentage of cases showing nuclear p53 protein varied according to the histological type; in the bowenoid type it was 4/7 (57%); in the atrophic type it was 1/7 (14%). Nuclear pyrimidine dimers were not stained in solar keratosis, although the skin of UV-irradiated nude mice was positive. Accumulation of p53 protein is a good marker for early precancerous change caused by UV exposure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01212722
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    Paper (German National Licenses)
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