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  • 1
    Digitale Medien
    Digitale Medien
    Determination of Calcium Content in Individual Biological Cells by Inductively Coupled Plasma Atomic Emission Spectrometry (1994)
    s.l. : American Chemical Society
    Analytical chemistry 66 (1994), S. 3000-3004 
    Details
    ISSN: 1520-6882
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/ac00091a004
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  • 2
    Digitale Medien
    Digitale Medien
    Partial kidney transplantation: a successful kidney transplantation in a child with severe cardiac failure by surgical mass reduction of an adult donor kidney (1993)
    Springer
    Transplant international 6 (1993), S. 173-175 
    Details
    ISSN: 1432-2277
    Schlagwort(e): Kidney transplantation, child ; Child, kidney transplantation, reduced size ; Reduced size kidney transplantation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We report on a trial of partial kidney transplantation performed on a low body weight child with impaired cardiac function due to mitral valve stenosis and uremic cardiomyopathy. The weight of the donated kidney was successfully reduced by one-third using bench surgery in order to obtain sufficient graft perfusion and function. Our procedure is justified when a graft is too large to be adequately perfused in a recipient suffering from cardiac failure.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00336364
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  • 3
    Digitale Medien
    Digitale Medien
    An electron microscopic study of glomerular lesions in hereditary nephrotic mice (ICGN strain) (1990)
    Springer
    Virchows Archiv 417 (1990), S. 223-228 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Mouse ; Nephrotic syndrome ; Hereditary nephritis ; Electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Glomerular lesions in hereditary nephrotic mice (ICGN strain) were investigated by electron microscopy. The glomeruli of unaffected animals, which appeared normal by light microscopy, had developed an ultrastructural change in the glomerular capillary basement membrane (GCBM). There was a partial thickening of the GCBM with bilaminar splitting of the lamina densa and an electron-dense fibrillar material exhibiting cross-striations. In affected animals, light microscopy revealed a marked thickening of GCBM and an increase of mesangial matrix without cellular proliferaton. By electron microscopy, multilaminar splitting of the lamina densa in the thickened GCBMs and fusion of the epithelial foot processes were observed. In some severely affected animals, immune complex deposition was found in GCBM, but little if any was observed in other animals. In the end, the glomeruli were globally sclerosed. Our findings suggest that initial structural abnormalities in GCBM may play an important role in the onset and development of the disease, though subsequent events such as immune complex deposition would modify the disease.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01600137
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  • 4
    Digitale Medien
    Digitale Medien
    Separation and determination of dissolved and particulate humic substances in river water (1994)
    Springer
    Microchimica acta 113 (1994), S. 269-276 
    Details
    ISSN: 1436-5073
    Schlagwort(e): humic substances ; suspended particles ; membrane-filter dissolution ; surfactant-coated filter ; sorption ; spectrophotometry ; river water analysis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Distribution of humic and fulvic acids in participate or dissolved form is studied by using simple leaching and sorption techniques. After filtration of water sample (100–200 ml), the filter along with suspended particles is treated with 5 ml of chloroform and 3 ml of 0.1 mol/l sodium hydroxide solution. The filter dissolves completely in the organic phase, while the suspended particles remain in the aqueous phase enabling a leaching of humic substances. The leaching is repeated once more with 2 ml of 0.1 mol/l sodium hydroxide solution. The humic and fulvic acids in the combined solution are fractionated at pH l by filtration, where the membrane filter is preliminarily coated with sodium dodecyl sulfate. On the other hand, dissolved humic substances are concentrated from a 50-ml filtered sample by sorption on a DEAE-cellulose column. They are desorbed with 5 ml of 0.1 mol/l sodium hydroxide solution and fractionated at pH 1. The spectrophotometric analysis of river water reveals that fulvic acid is predominant in suspended particles as well as in filtered samples. The concentration of dissolved humic and fulvic acids is approximately ten times that of suspended particles.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01243617
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  • 5
    Digitale Medien
    Digitale Medien
    Coprecipitation with metal hydroxides for the determination of beryllium in seawater by graphite furnace atomic absorption spectrometry (1994)
    Springer
    Microchimica acta 117 (1994), S. 7-13 
    Details
    ISSN: 1436-5073
    Schlagwort(e): beryllium ; seawater ; Coprecipitation ; magnesium hydroxide ; tin(IV) hydroxide ; graphite furnace atomic absorption spectrometry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Coprecipitation first with magnesium hydroxide, next with tin(IV) hydroxide is developed for the determination of traces of beryllium in sea-water. To a 200-ml sample is added a sodium hydroxide solution to form magnesium hydroxide at pH 11.5, on which beryllium is quantitatively coprecipitated. The precipitate is separated by centrifugation and dissolved in 2 ml of 12 mol/l hydrochloric acid. The resulting solution (ca. 10 ml) is mixed with 2 mg of tin (IV) carrier and the pH is adjusted to 5.0 to collect the beryllium on tin (IV) hydroxide, leaving magnesium ions in the solution. The tin (IV) hydroxide is centrifuged, dissolved in 0.1 ml of 5 mol/l hydrobromic acid, and then diluted to 1 ml with water. Magnesium is so added as to be 500 μg/ml for increasing the sensitivity about four times, and the beryllium in the solution is determined by graphite furnace atomic absorption spectrometry. The experiments with synthetic seawater samples showed that pg — μg amounts of beryllium can be coprecipitated on the metal hydroxides and beryllium at the low ng/1 level can be determined with reasonable precision (RSD 〈 10%). The detection limit of the proposed method is 0.5 ng/l of beryllium in seawater.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01243011
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  • 6
    Digitale Medien
    Digitale Medien
    C4 genes of the chimpanzee, gorilla, and orang-utan: evidence for extensive homogenization (1992)
    Springer
    Immunogenetics 35 (1992), S. 16-23 
    Details
    ISSN: 1432-1211
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract The human complement component 4 is encoded in two genes, C4A and C4B, residing between the class I and class II genes of the major histocompatibility complex. The C4A and C4B molecules differ in their biological activity, the former binding more efficiently to proteins than to carbohydrates while for the latter, the opposite holds true. To shed light on the origin of the C4 genes we isolated cosmid clones bearing the C4 genes of a chimpanzee, a gorilla, and an orang-utan. From the clones, we isolated the fragments coding for the C4d part of the gene (exons and introns) and sequenced them. Altogether we sequenced eight gene fragments: three chimpanzee (Patr-C4-1 *01, Patr-C4-1 *02, Patr-C4-2 *01), two gorilla (Gogo-C4-1 *01, Gogo-C4-2 *01), and three orang-utan (Popy-C4-1 *01, Popy-C4-2 *01, Popy-C4-3 *01). Comparison of the sequences with each other and with human C4 sequences revealed that in the region believed to be responsible for the functional difference between the C4A and C4B proteins the C4A genes of the different species fell into one group and the C4B genes fell into another. In the rest of the sequence, however, the C4A and C4B genes of each species resembled each other more than they did C4 genes of other species. These results are interpreted as suggesting extensive homogenization (concerted evolution) of the C4 genes in each species, most likely by repeated unequal, homologous, intragenic crossing-over.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00216622
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  • 7
    Digitale Medien
    Digitale Medien
    Renal pathology in rats bearing tumour-secreting growth hormone (1991)
    Springer
    Pediatric nephrology 5 (1991), S. 533-538 
    Details
    ISSN: 1432-198X
    Schlagwort(e): Growth hormone ; Insulin-like growth factor-I ; Glomerular hypertrophy ; Glomerulosclerosis ; Glomerular hyperperfusion ; Rats
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The effects of growth hormone (GH) on renal structure and function were investigated in rats aged 10–16 weeks bearing a tumour secreting GH. Body weight gain, food intake, urine volume, and urinary excretion of cretinine and urea nitrogen were significantly greater in tumour-bearing rats than in controls. The tumour-bearing rats presented progressive proteinuria, hyperproteinaemia, and hyperlipidaemia. Creatinine clearance was significantly higher in experimental animals during the early experimental stage, but decreased as the glomerular lesions progressed, associated with a rise in serum creatinine levels. The glomeruli became progressively enlarged with degenerative changes of the visceral epithelial cells and capsular adhesions. In advanced stages proteinaceous material invaded the subcapsular space and the capillary lumen collapsed finally leading to glomerulosclerosis. Except for the presence of proteinaceous material and damaged epithelial cells the glomerular lesions resemble those observed experimentally after reduction of renal mass, and in diabetes mellitus. We speculate that the pathological features described are due to effects of persistently high levels of circulating GH on the glomerular cells.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01453696
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  • 8
    Digitale Medien
    Digitale Medien
    Somatic growth in corticosteroid-trated rats with passive Heymann nephritis —effects of recombinant human growth hormone on growth impariment (1991)
    Springer
    Pediatric nephrology 5 (1991), S. 603-606 
    Details
    ISSN: 1432-198X
    Schlagwort(e): Growth ; Corticosteroid ; Growth hormone ; Insulin-like growth factor-1
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We evaluated the efficacy of recombinant human growth hormone (r-hGH) on corticosteroid (CS)-induced growth-impaired rats with proteinuria (passive Heymann nephritis). R-hGH (2 IU twice daily) improved growth in rats treated with 20 mg/kg per day of prednisolone succinate in our 4-week study. Although plasma hGH was significantly increased in rats treated with r-HGH, plasma insulin-like growth factor-1 levels were not different between treated and untreated rats. The food utilization rate was significantly improved by r-hGH. R-hGH did not affect proteinuria, renal function, or calcium and phosphate metabolism. Our results suggest that r-hGH may be effective in improving growth impairment due to CS administration.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00856650
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  • 9
    Digitale Medien
    Digitale Medien
    Treatment with a combination of low-density lipoprotein aphaeresis and pravastatin of a patient with drug-resistant nephrotic syndrome due to focal segmental glomerulosclerosis (1993)
    Springer
    Pediatric nephrology 7 (1993), S. 196-198 
    Details
    ISSN: 1432-198X
    Schlagwort(e): Low-density lipoprotein aphaeresis ; Pravastatin ; Nephrotic syndrome ; Focal segmental glomerulosclerosis ; Hyperlipidaemia
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Results of recent animal studies have lent support to the hypothesis that hyperlipidaemia may contribute to renal injury. This report documents the case of a 15-year-old boy with drug-resistant nephrotic syndrome due to focal segmental glomerulosclerosis (FGS) who showed an improvement in renal function and proteinuria as a result of treatment with low-density lipoprotein aphaeresis (LDL-A) combined with pravastatin. Although further work is required to determine the efficacy of lipidlowering therapy in progressive glomerular disease in humans, the combination of LDL-A and pravastatin is likely be included in the choice of treatment modalities available for patients with drug-resistant nephrotic syndrome due to FGS.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00864397
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  • 10
    Digitale Medien
    Digitale Medien
    Dynamical behavior of psb gene transcripts in greening wheat seedlings. I. Time course of accumulation of the psbA through psbN gene transcripts during light-induced greening (1992)
    Springer
    Plant molecular biology 20 (1992), S. 695-704 
    Details
    ISSN: 1573-5028
    Schlagwort(e): chloroplast ; gene expression ; photosystem 2 ; transcription ; wheat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The time course of the accumulation of the transcripts from 13 psb genes encoding a major part of the proteins composing photosystem II during light-induced greening of dark-grown wheat seedlings was examined focusing on early stages of plastid development (0.5 h through 72 h). The 13 genes can be divided into three groups. (1) The psbA gene is transcribed as a single transcript of 1.3 kb in the dark-grown seedlings, but its level increases 5- to 7-fold in response to light due to selective increase in RNA stability as well as in transcription activity. (2) The psbE-F-L-J operon, psbM and psbN genes are transcribed as a single transcript of 1.1 kb, two transcripts of 0.5 and 0.7 kb and a single transcript of 0.3 kb, respectively, in the dark-grown seedlings. The levels of accumulation of every transcript remain unchanged or rather decrease during plastid development under illumination. (3) The psbK-I-D-C gene cluster and psbB-H operon exhibit fairly complicated northern hybridization patterns during the greening process. When a psbC or psbD gene probe was used for northern hybridization, five transcripts differing in length were detected in the etioplasts from 5-day old dark-grown seedlings. After 2 h illumination, two new transcripts of different length appeared. Light induction of new transcripts was also observed in the psbB-H operon.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00046454
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