ISSN:
0894-3230
Keywords:
Organic Chemistry
;
Physical Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
,
Physics
Notes:
Both the regioselectivity and the reaction rate for the β-cyclodextrin (β-CyD)-induced P-O(3′) cleavage of adenosine 2′, 3′-cyclic phosphate (A 〉 p) to adenosine 2′-phosphate are greatly promoted by KF. The promoting activity of KF is much larger than that of KCl. KF amplifies the difference in the chemical circumstance between the P-O(2′) and the P-O(3′) bonds of A 〉 p, induced by β-CyD on complex formation with A 〉 p. The higher activity of KF is ascribed to absence of complex formation of F- ion with β-CyD, which results in deeper penetration of A 〉 p into the cavity of β-CyD.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/poc.610050812
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