ISSN:
1365-3083
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
The differential effects that the binding of interleukin 2(IL-2)to its β or αβ receptors might induce in two different CD4− CD8− T-cell lines were analysed. While LDl. T3b, a double-negative T cell derived from MRL/Ipr mice, constitutively expressed high levels of the IL-2R β chain, YAC-1, a Moloney sarcoma virus-transformed CD4− CD8−T cell, expressed (as an activated T cell) the β and α chains. The presence of IL-2 in the culture medium was lethal for LDl. T3b cells, while it had no effect on the growth of YAC-1 cells. IL-2 increased the exprcssion of the β chain and, to a lesser extent, of the α chain in YAC-1 cells. In addition, other markers such as CD4 and CD5 were induced by IL-2 in this celt line.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-3083.1990.tb02796.x
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