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  • 1990-1994  (2)
  • 1
    ISSN: 1615-2573
    Keywords: Takayasu arteritis ; Aortography ; Coronary angiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Clinical and angiographic features of Takayasu arteritis were investigated in 129 Korean patients. This disease affects females more frequently than males, in a ratio of 6.6 to 1. Of the total number of patients, 51 were in the third decade, 27 in the fourth decade, and 23 in the second decade. Common clinical symptoms were headache (60%), exertional dyspnea (42%), dizziness (36%), and malaise or weakness (34%). Takayasu arteritis affected the abdominal aorta (46%) and descending thoracic aorta (37%) more frequently than the ascending aorta (1%) and aortic arch (2%) According to Ueno's classification based on aortographic findings, the 129 patients were divided into type I (37), type II (25), and type III (67). Among the 48 patients who had coronary angiography, 11 (23%) showed coronary arterial involvement. Because the clinical features are determined by the extent and severity of the specific artery involved in the occlusive phase of the disease, total aortography including coronary angiography is very important in the initial evaluation of Takayasu arteritis.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Heart and vessels 7 (1992), S. 81-84 
    ISSN: 1615-2573
    Keywords: Takayasu arteritis ; HLA ; Korean
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Takayasu arteritis occurs with a strong predilection for women and particular geographic areas, and as related to the etiology of the disease, association of HLA antigens has been suggested. In the present study, the authors investigated the association of Takayasu arteritis with class I and class II HLA antigens in 59 Korean patients with this disease. Increased frequencies of HLA-Bw52 (χ 2 6.213,P 〈 0.02), Cw6 (χ 2 4.132,P 〈 0.05), DR7 (χ 2 4.506,P 〈 0.04), and DQw2 (χ 2 7.327,P 〈 0.01) were observed in the patient group as compared to the control group of healthy Koreans. In the Korean population, 2 risk factors in the HLA system for developing this disease appear to be (1) Bw52 and (2) DR7 and a probable haplotype ofCw6, B13, DR7, DQw2. Previous studies of the Japanese population revealed association of Bw52 and class II HLA antigens (DR2, Dw12), which are in linkage disequilibrium with Bw52. It is of interest that in the Korean population, class II antigens (DR7, DQw2), which are not linked to BW52, are associated with the disease. This finding suggests that the disease susceptibility gene of Takayasu arteritis is located between theHLA-B locus andHLA-DR, DQ loci.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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