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  • 1
    Electronic Resource
    Electronic Resource
    Carbamazepine and its 10,11-epoxide metabolite in acute mania: clinical and pharmacokinetic correlates (1991)
    Springer
    European journal of clinical pharmacology 41 (1991), S. 541-546 
    Details
    ISSN: 1432-1041
    Keywords: Carbamazepine ; Saliva ; Mania ; Carbamazepine epoxide ; drug concentration ; Concentration-response relationship ; therapeutic monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The study was designed to investigate the antimanic profile of carbamazepine as a first-line drug in affective or schizoaffective disorders, to correlate the clinical efficacy with the plasma level of carbamazepine and its 10,11-epoxide metabolite, and to test the potential value of monitoring the salivary level. It was administered alone for 3 weeks to 21 acute manic inpatients. During the first week, the dosage was rapidly increased to 800 mg/day in order to produce steady-state plasma levels of carbamazepine on Day 7. The individual dose was then adjusted to maintain the therapeutic range of 8–12 mg/l. Plasma and saliva levels of the drug and its metabolite, as well as clinical status were assessed weekly. Overall, there was 62% globally improved patients and 77% in affective disorders. The improvement of manic symptoms was significantly lower in schizoaffective than in affective disorders, whereas the dropout rate and the need for antipsychotic medication was higher in the former group. The antimanic response was significantly correlated with the plasma levels both of carbamazepine and its epoxide metabolite, with a time-lag consistent with a delayed drug effect. Drug and metabolite concentrations in saliva were close to their plasma free fraction and were strongly correlated with their plasma levels, suggesting the potential value of salivary drug monitoring.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314982
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  • 2
    Electronic Resource
    Electronic Resource
    Silica-zirconia monoliths from gels (1994)
    Springer
    Journal of sol gel science and technology 2 (1994), S. 875-880 
    Details
    ISSN: 1573-4846
    Keywords: gels ; silica zirconia ; monoliths ; DCCA ; methoxyethanol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Zirconium propoxide and tetraethylorthosilicate were hydrolyzed in methoxyethanol which acts as stabilizer of zirconium and in presence of formamide or dimethylformamide as Drying Control Chemical Additives in order to obtain zirconia silica gels. The gels were dried at 70°C to get monolithic xerogels. The influence of zirconium content and DCCA on texture was determined. The evolution of these xerogels was investigated as a function of temperature between 70°C and 1000°C by thermogravimetry, differential scanning calorimetry, I.R. spectroscopy and R.X. diffractometry.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00486368
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  • 3
    Electronic Resource
    Electronic Resource
    Prognostic significance of early intracranial and cerebral perfusion pressures in post-cardiac arrest anoxic coma (1991)
    Springer
    Intensive care medicine 17 (1991), S. 392-398 
    Details
    ISSN: 1432-1238
    Keywords: Out of hospital cardiac arrest ; Anoxic coma ; Intracranial pressure ; Cerebral perfusion pressure ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The prognosis of prolonged cardiac arrests is generally related to brain damage due to the cerebral anoxia. A neurological worsening leading to irreversibility is sometimes associated with an increase in intracranial pressure. We studied for 5 years the early intracranial and cerebral perfusion pressures in 84 patients with deep anoxic coma after cardiac arrest. Intracranial pressure monitoring was set up as soon as possible with an extradural screw over a period of 6 days. No complications occured using this technique. We recorded the percentage of patients suffering from intracranial pressure peaks over 15 mmHg (a), over 25 mmHg (b) or cerebral perfusion pressures drops under 50 mmHg (c). We obtained during the 1 st day of monitoring: (a) 46.4%, (b) 21.4%, (c) 39%; during the 2nd day: (a) 73.6%, (b) 26.3%, (c) 55.9%. Eight patients (9.5%) were still alive after a couple of months, 4 of whom had no neurological sequelae; among the 76 non-survivors 63 (82.9%) had died because of cerebral anoxic damage. A daily comparison between survivors and non-survivors points out that the survivors' intracranial pressures were always lower than in the nonsurvivors and the survivors' cerebral perfusion pressures higher than in the non-survivors. Moreover, none of the patients showing intracranial peak pressures over 25 mmHg survived without after-effects. It is clear that many patients suffer early periods of high intracranial pressures and low cerebral perfusion pressures leading to a bad neurological prognosis. Intracranial pressure monitoring may allow assessment of patients' neurological status and prognosis after cardiac resuscitation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01720676
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  • 4
    Electronic Resource
    Electronic Resource
    Physeal and epiphyseal extent of primary malignant bone tumors in childhood (1993)
    Springer
    Pediatric radiology 23 (1993), S. 421-424 
    Details
    ISSN: 1432-1998
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Twenty-two patients with metaphyseal primary malignant bone tumors (17 osteosarcomas, 5 Ewing's tumors) occurring before closure of the growth plate were examined with plain radiographs and MRI in order to determine the physeal or epiphyseal extent of the tumor. Results were correlated with the pathologic examination. Transphyseal spread was pathologically proven in 13 cases (59%): 12 cases of osteosarcoma and 1 case of Ewing's tumor (70% and 20%, respectively). There was no significant relation between epiphyseal invasion, age of patient, length of tumor or, in the cases of osteosarcoma, response to chemotherapy. Plain radiographs showed epiphyseal involvement in 4 cases and there were 10 false negatives. MRI revealed epiphyseal involvement in all cases; there were no false positives or false negatives. T1-weighted images in coronal or sagittal planes appeared to be sufficient. These findings are very useful in planning surgical limb salvage procedures and stress the ineffectiveness of the “barrier effect” of the growth plate against tumor spread.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02012438
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  • 5
    Electronic Resource
    Electronic Resource
    Calcifications in untreated primary duodenal lymphoma: An exceptional entity (1994)
    Springer
    Pediatric radiology 24 (1994), S. 283-284 
    Details
    ISSN: 1432-1998
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Calcifications in lymphoma are rare findings prior to therapy. We report our experience with a 13-year-old boy who presented with a primary calcified duodenal Burkitt's lymphoma. US and CT findings are described. Two differential diagnoses are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02015459
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    In vitro study on the integrity of a hydroxylapatite coating when challenged with staphylococci (1993)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 27 (1993), S. 775-781 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: An in vitro study was performed to evaluate the effect of Staphylococcus aureus and Staphylococcus epidermidis on the integrity of a hydroxylapatite coating. The coating plasmasprayed on poly(L-lactide), showed dissolution during a 24 h incubation period. This was indicated by an increase in pH and calcium release in the buffer solution., After 4 h of incubation, calcium levels decreased due to the precipitation of calcium phosphate complexes on the coating. The bacteria digested or dissolved the coating, creating irregularly shaped holes. Although the integrity of the hydroxylapatite coating was focally damaged within 2-4 h of incubation with staphylococci, the extent of the damage was only marginal. Due to the formation of a layer of CaP precipitates though, bacteria could not be counted accurately after 4-8 h of incubation. This model could reveal part of the failure mechanism of infected hydroxylapatite coated implants. © 1993 John Wiley & Sons, Inc.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820270610
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