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  • 1
    Electronic Resource
    Electronic Resource
    Effect of a new hypoglycaemic agent (HB 699) on the in vivo secretion of pancreatic hormones in the dog (1981)
    Springer
    Diabetologia 20 (1981), S. 501-505 
    Details
    ISSN: 1432-0428
    Keywords: Acyl-amino-alcyl benzoic acid derivative ; hypoglycaemic agent ; insulin release ; pancreatic polypeptide ; glucagon ; somatostatin ; tolbutamide ; unanaesthetized dogs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of HB 699, a non-sulphonyl urea acyl-amino-alcyl benzoic acid derivative, were studied in unanaesthetized dogs. Changes in blood glucose and plasma insulin, glucagon, pancreatic polypeptide and somatostatin were measured after a single intravenous injection. HB 699 caused hypoglycaemia and stimulated insulin secretion in a dosedependent manner. The effects of HB 699 (40 mg/ kg) on pancreatic hormone secretion were compared to those of tolbutamide given at a dose (12 mg/kg) which induced a similar maximal hypoglycaemia. Both drugs caused a similar increase in insulin release (180±32% for tolbutamide and 240±41% for HB 699) lasting for approximately 1 hour. Despite hypoglycaemia, plasma glucagon concentrations were unaltered by either substance. HB 699 caused a marked increase in the secretion of pancreatic polypeptide (220±60% at 30 min) for up to 2 hours, whereas tolbutamide caused no significant change in plasma pancreatic polypeptide levels. In contrast, while tolbutamide caused a significant (45±12%) but short-lived increase in plasma somatostatin concentrations, HB 699 had no significant effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253415
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Differences between the effects of adrenaline and noradrenaline on insulin secretion in the dog (1983)
    Springer
    Diabetologia 24 (1983), S. 107-112 
    Details
    ISSN: 1432-0428
    Keywords: Insulin secretion ; adrenaline ; noradrenaline ; catecholamines ; dog ; blood glucose ; propranolol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of adrenaline and noradrenaline infusions on pancreaticoduodenal venous insulin output were studied in anaesthetized normal dogs. Two experimental protocols were used. In the first, the dogs had a normal blood glucose level at the start of the catecholamine infusion (normoglycaemic dogs). In the second, the animals were made hyperglycaemic by a continuous glucose infusion (hyperglycaemic dogs). In the normoglycaemic dogs, adrenaline (0.5 μg · kg-1 · min-1) provoked hyperglycaemia accompanied by an increase in insulin output. Noradrenaline (0.5 μg · kg-1 · min-1) also caused an increase in insulin output but without any significant change in blood glucose. In hyperglycaemic dogs, adrenaline (2 μg · kg-1 · min-1) reduced the insulin response and enhanced the hyperglycaemia; noradrenaline (2 μg · kg-1 · min-1) markedly increased the insulin response (+ 2250%) without any significant change in blood glucose. Propranolol (0.3 mg/kg, IV) prevented the increase of insulin induced by noradrenaline. These findings show that, in the normal dog, adrenaline and noradrenaline infusions can produce opposite effects on insulin response depending on the experimental conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00297391
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Carbamazepine and its 10,11-epoxide metabolite in acute mania: clinical and pharmacokinetic correlates (1991)
    Springer
    European journal of clinical pharmacology 41 (1991), S. 541-546 
    Details
    ISSN: 1432-1041
    Keywords: Carbamazepine ; Saliva ; Mania ; Carbamazepine epoxide ; drug concentration ; Concentration-response relationship ; therapeutic monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The study was designed to investigate the antimanic profile of carbamazepine as a first-line drug in affective or schizoaffective disorders, to correlate the clinical efficacy with the plasma level of carbamazepine and its 10,11-epoxide metabolite, and to test the potential value of monitoring the salivary level. It was administered alone for 3 weeks to 21 acute manic inpatients. During the first week, the dosage was rapidly increased to 800 mg/day in order to produce steady-state plasma levels of carbamazepine on Day 7. The individual dose was then adjusted to maintain the therapeutic range of 8–12 mg/l. Plasma and saliva levels of the drug and its metabolite, as well as clinical status were assessed weekly. Overall, there was 62% globally improved patients and 77% in affective disorders. The improvement of manic symptoms was significantly lower in schizoaffective than in affective disorders, whereas the dropout rate and the need for antipsychotic medication was higher in the former group. The antimanic response was significantly correlated with the plasma levels both of carbamazepine and its epoxide metabolite, with a time-lag consistent with a delayed drug effect. Drug and metabolite concentrations in saliva were close to their plasma free fraction and were strongly correlated with their plasma levels, suggesting the potential value of salivary drug monitoring.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314982
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    A new benzothiadiazine derivative, LN 5330: effects on pancreatic hormones (1984)
    Springer
    Diabetologia 27 (1984), S. 583-586 
    Details
    ISSN: 1432-0428
    Keywords: Benzothiadiazine analogue ; LN 5330 ; diazoxide ; glucagon ; insulin ; somatostatin secretion ; dog ; isolated perfused rat pancreas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary LN 5330 is a new benzothiadiazine which is a structural analogue of diazoxide. Its effects in vivo were studied on blood glucose levels and insulin, glucagon and somatostatin secretion in normal dogs, and in vitro on glucagon and insulin secretion from the isolated perfused rat pancreas. The results were compared with those obtained with diazoxide at equimolar dose or concentration. In the normal anaesthetized dog having a T-shaped catheter inserted in the pancreaticoduodenal vein, the infusion of LN 5330 (87.8 μmol/kg for 20 min) induced (1) a progressive increase in blood glucose levels, (2) a rapid decrease in insulin and somatostatin output rate, (3) an immediate increase in pancreatic glucagon secretion, and (4) a delayed decrease of arterial blood pressure. The equimolar dose of diazoxide provoked the same effects on blood glucose levels, insulin and somatostatin output, but a marked decrease in glucagon output and in arterial blood pressure. In the isolated rat pancreas perfused with 8.3 mmol/l glucose, the infusion of LN 5330 (440 μmol/l for 30 min) induced a drastic fall in insulin and a rapid and persistent increase in glucagon output. This stimulatory effect on glucagon secretion was not found with diazoxide at equimolar concentration. These findings show that LN 5330 is a substance which is distinct from diazoxide and interesting because of its double action: inhibition of insulin secretion and stimulation of glucagon secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00276972
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    Paper (German National Licenses)
    Fulltext
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