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  • 1
    Electronic Resource
    Electronic Resource
    An autopsy case of human T lymphotropic virus type I-associated myelopathy (HAM) with a duration of 28 years (1990)
    Springer
    Acta neuropathologica 81 (1990), S. 219-222 
    Details
    ISSN: 1432-0533
    Keywords: HTLV-I ; Tropical spastic paraparesis ; Chronic progressive myelopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An autopsy case of human T lymphotropic virus I-associated myelopathy (HAM) of a duration of 28 years in a 61-year-old man with serological confirmation of HTLV-I infection was reported. The spinal cord was grossly atrophic. There was severe symmetrical degeneration of the lateral funiculi, particularly of the bilateral pyramidal tracts, involving all levels of the spinal cord, but anterior horn cells were relatively well preserved. In the most severely damaged middle and lower thoracic segments, the white matter degeneration also involved the anterior funiculi. In the degenerated white matter, both the myelin and axons were equally lost and had been replaced by glial scars. Marked adventitial fibrosis was commonly seen in small parenchymal vessls in both the white and gray matter. Although there was no evidence of inflammation in the spinal cord, mild lymphocytic infiltration was occasionally observed in the subarachnoid and perivascular spaces in the brain stem, cerebellum and cerebrum. This case was considered as a burnt-out case of HAM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00334512
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  • 2
    Electronic Resource
    Electronic Resource
    Immunocytochemical and ultrastructural studies of hyaline inclusions in sporadic motor neuron disease (1991)
    Springer
    Acta neuropathologica 82 (1991), S. 295-301 
    Details
    ISSN: 1432-0533
    Keywords: Hyaline inclusions ; Motor neuron disease ; Amyotrophic lateral sclerosis ; Immunocytochemistry ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We investigated hyaline inclusion bodies (HI) immunocytochemically and ultrastructurally in six cases of sporadic motor neuron disease (MND). All HI contained large amounts of ubiquitin and some HI were stained at the core or the center with anti-neurofilament antibody, with the surrounding halo unstained. No HI were stained with antibodies raised against cytoskeletal proteins such as high-molecular weight microtubule-associated proteins and phosphorylated tau. Ultrastructurally, HI were chiefly composed of filaments measuring about 20 nm in diameter thicker than neurofilaments, and contained fine granules and frequently one or more of four characteristic profiles, i.e., small electron-dense materials resembling Bunina bodies, bundles of tubular filaments measuring approximately 20 nm in diameter, large electron-dense cores, and focal accumulations of randomly arranged neurofilaments. Hyaline inclusions can be regarded as one of the characteristic markers for sporadic MND as well as familial amyotrophic lateral sclerosis. Hyaline inclusions have a markedly heterogeneous ultrastructure and, therefore, differences in immunoreactivity with antineurofilament antibodies are not unexpected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00308815
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  • 3
    Electronic Resource
    Electronic Resource
    Sporadic amyotrophic lateral sclerosis with extensive neurological involvement (1992)
    Springer
    Acta neuropathologica 84 (1992), S. 211-215 
    Details
    ISSN: 1432-0533
    Keywords: Amyotrophic lateral sclerosis ; Respirator support ; Long survival ; Extensive involvement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report an autopsy case of respirator-assisted long-survival sporadic amyotrophic lateral sclerosis (ALS) with extensive involvement extending beyond the motor system. The involved areas included the globus pallidus, subthalamic nucleus, red nucleus, substantia nigra, Clarke's column, intermediolateral nucleos, Onuf's (Onufrowicz) nucleus, middle root zone of the posterior column, and the spinocerebellar tract. There was no impairment of ocular movements. Such sporadic ALS cases with extensive involvement extending beyond the motor system may constitute a distinct subgroup of this disease that differs from long-survival ALS (with or without respirator support) in which only the motor system is affected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00311398
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  • 4
    Electronic Resource
    Electronic Resource
    Immunocytochemical and ultrastructural studies of the motor cortex in amyotrophic lateral sclerosis (1994)
    Springer
    Acta neuropathologica 87 (1994), S. 578-585 
    Details
    ISSN: 1432-0533
    Keywords: Amyotrophic lateral sclerosis ; Motor cortex ; Betz cells ; Immunocytochemistry ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This report concerns an immunocytochemical and ultrastructural study of the motor cortices of 11 patients with amyotrophic lateral sclerosis (ALS). Specimens from 12 normal individuals served as controls. Antibodies against phosphorylated neurofilament (PNF; 200 kDa), ubiquitin, glial fibrillary acidic protein (GFAP) and phosphorylated tau protein were used. The pyramidal cells of layer III of all ALS patients were stained, with varying intensities, by the antibody to PNF. By contrast, Betz cells reacted less frequently with this antibody. Staining for GFAP was noted in numerous astrocytes in layer III and at the transition between white matter and motor cortex of most patients. Ubiquitin-positive inclusions were only occasionally seen in Betz cell and pyramidal cell of layer V. These observations indicate that alterations of the motor cortex occur first in the pyramidal cells of layer III rather than in Betz cells. Pyramidal cells and Betz cells were not stained by the antibody to phosphorylated tau protein. In controls, pyramidal cells and Betz cells were less frequently stained with the anti-neurofilament antibody than those from ALS patients. Immunoreactivity of GFAP in layer III and at the junction of white matter and motor cortex was observed in only one patient. Ultrastructural examination revealed that the Betz cells of some ALS patients had Bunina bodies (BB), Lewy body-like inclusions (LBI) and skein-like inclusions (SI), as well as bundles of filaments that were thicker than neurofilaments; some of these filaments appeared to be constricted. The incidence of these inclusions was lower than that seen in anterior horn neurons. Cytoplasmic inclusions such as BB, LBI, and SI were not observed in any of the controls. Our findings suggest that the cytopathology of upper motor neurons is similar to that of lower motor neurons and that the changes seen in Betz cells appear to be a reflection of the lower motor neuron alterations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00293318
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  • 5
    Electronic Resource
    Electronic Resource
    Pressure-induced phase transition in solid hydrogen sulfide at 11 GPa (1991)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 95 (1991), S. 2036-2040 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The Raman spectra of hydrogen-bonded molecular solid H2S have been measured up to 23 GPa at 300 K in a gasketed diamond-anvil cell. In the orientationally disordered phase I between 0.47 and 11 GPa, the symmetric stretching mode ν1 shows a red-shift in frequency (dν1/dP=−10.1 cm−1/GPa ) and a dramatic broadening with pressure. At about 11 GPa, the antisymmetric stretching band ν3 appears at the higher-frequency side of ν1. Near this same pressure five low-frequency vibrational modes also appear and show pressure-sensitive features. These results indicate a pressure-induced phase transition near 11 GPa. This new solid phase, which persists to at least 23 GPa at 300 K, seems to be the same phase as previously found above 3.3 GPa at 25 K.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.461002
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  • 6
    Electronic Resource
    Electronic Resource
    TONIC CONTROL OF SUBRETROFACIAL VASOMOTOR NEURONS IN THE ROSTRAL VENTROLATERAL MEDULLA (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 18 (1991), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Vasomotor pressor neurons in the subretrofacial nucleus of the rostral ventrolateral medulla receive afferent inputs from different sources that utilize different neurotransmitters. This paper briefly reviews recent studies on the role of inputs releasing: (i) GABA, and (ii) angiotensin II (AII) in the subretrofacial nucleus.2. There are two types of tonic GABAergic inhibitory inputs: one arises from peripheral baroreceptors, while the second is independent of peripheral baroreceptors.3. Blockade of receptors for AII elicits a decrease in blood pressure and sympathetic vasomotor activity, indicating that subretrofacial neurons are also tonically excited by AII. It is likely that the AII is released from nerve terminals in the subretrofacial nucleus, but the origin of the pathway is unknown.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1991.tb01415.x
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  • 7
    Electronic Resource
    Electronic Resource
    Computation and management of chemical properties in CACTVS: An extensible networked approach toward modularity and compatibility (1994)
    s.l. : American Chemical Society
    Journal of chemical information and modeling 34 (1994), S. 109-116 
    Details
    ISSN: 1520-5142
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ci00017a013
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  • 8
    Electronic Resource
    Electronic Resource
    Application of a digital 1H-NMR spectrum to the survival test of substructures and the assignment test (1994)
    s.l. : American Chemical Society
    Journal of chemical information and modeling 34 (1994), S. 735-744 
    Details
    ISSN: 1520-5142
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ci00020a007
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  • 9
    Electronic Resource
    Electronic Resource
    Introduction of NOE data to an automated structure elucidation system, CHEMICS. Three-dimensional structure elucidation using the distance geometry method (1994)
    s.l. : American Chemical Society
    Journal of chemical information and modeling 34 (1994), S. 745-751 
    Details
    ISSN: 1520-5142
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ci00020a008
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  • 10
    Electronic Resource
    Electronic Resource
    (NH4)2Sx-treated InP(001) studied by high-resolution x-ray photoelectron spectroscopy (1994)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 76 (1994), S. 3059-3062 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The chemical state of sulfur on (NH4)2Sx-treated InP(001) surfaces has been studied by high-resolution x-ray photoelectron spectroscopy. We find three kinds of chemical states of sulfur (S2p3/2 lines at 161.2, 162.0, and 163.4 eV) on the sample treated at RT. It is suggested that they correspond to sulfur in phosphorus sites (in the second layer of the InP(001) surface), to sulfur bonded to indium on the first layer, and to elemental sulfur on sulfide, respectively. One (S2p3/2=162.0 eV) of them becomes predominant with long-time exposure to atmosphere at RT. Upon annealing the sample at 400 °C, the 163.4 eV line disappears, while the lines at 162.0 and 161.2 eV remain on the surface. A model of the treated surface is presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.357487
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