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  • 1
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    Berlin : Periodicals Archive Online (PAO)
    Kant-Studien. 81:4 (1990) 413 
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  • 2
    ISSN: 1399-3054
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The incorporation of 14C-leucine into the total-protein fraction of needles of Norway spruce (Picea abies [L.] Karst.) during short time incubation was used as a measure of protein synthesis in the light and in the dark. Light saturation curves, obtained for needles of different ages (new flush and 1 and 2 years old) or at different seasons (summer-winter) followed the Michaelis-Menten algorithm, exhibiting marked differences with regard to light saturation (Vmax) and the half-saturation constant (K5. 2). The light saturation curves of ATP level (mg g−1 fresh weight) and of leucine incorporation into protein (nmol mg−1 h−1) matched each other, suggesting that photophosphorylation may be decisive for the rate of protein synthesis in the light. This is confirmed by the action spectrum of leucine incorporation. which resembled an action spectrum of leaf photosynthesis, and also by partial inhibition of protein synthesis by 3-(3,4-dichlorophenyl)-1,1-dimethylurea (DCMU), an inhibitor of non-cyclic photophosphorylation. Light stimulated protein synthesis showed pronounced seasonal fluctuations with a summer maximum.Furmigation of 5 years old spruce trees for 3 months with SO2 in combination with O3 and/or NO2 caused a distinct enhancement of the protein synthesis rate in the light and, at a reduced absolute level, also in the dark. A similar result was obtained for 40 to 70 years old spruce stands when healthy and sick trees were compared: the latter being afflicted by the novel type of forest decline, which is characterized by yellowish bronze discolouration of sun-exposed older needles and partial loss of older needle generations (3 to 4 years old). The 1 year old needles of the unhealthy trees showed a markedly increased 14C-leucine incorporation rate which, in the dark, was even more pronounced than in the light. Stress-physiological mechanisms, which could possibly explain this stimulation, are discussed.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Elastic electron deuteron scattering has been measured at the Bonn 2.5 GeV electron-synchrotron using a tensor polarized ND3 target. The scattered electrons and deuterons were detected in coincidence by two magnetic spectrometers. Data were taken at an average value of four momentum transfer ofQ 2=0.495 (GeV/c)2 in order to separate the electric monopole and quadrupole form factors of the deuteron. To have a sufficient control of systematic effects, both polarized and unpolarized cross sections were measured with an identical experimental set up. In the ratioR EXP=dσpol/dσunp systematic effects are expected to cancel. This ratioR EXP is related to the theoretical polarized cross section d dσ T where the spin quantization axis for the deuterons is orientated in the ed-scattering plane, perpendicular to the virtual photon direction. Our final result for the corresponding recoil tensor polarization ist 20=−2.01±1.13.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1572-8838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Notes: Abstract Experimental results for the electrodeposition of Ni-Zn alloys from chloride solutions, with addition of H3BO3 and without other additives, in a laboratory cell with a perforated nickel sheet cathode and with recirculating electrolyte are presented. The dependence of the zinc content in the alloy on the following operating conditions was investigated: cathodic current density, 1.0–20.0 A dm−2; temperature, 35–65°C; pH 1.5–5.5; total molarity,M tot=M Ni 2+ +M Zn 2+ =1.1–2.8 M; and, molar ratio,P=M Ni 2+ /M Zn 2+ =1.0–15. Depending on the operating conditions the Zn content in the alloy varied over the range 22–88 mol%. In separate experiments galvanostatic polarization curves were measured in the direction of increasing and then decreasing cathodic current density in the range 0.1–20.0 A dm−2 with all other operating conditions as used for electroplating experiments. In all cases significant hysteresis effects were observed. It was found that the current efficiency for the electrodeposition of Ni-Zn alloys from chloride solutions as a function of the zinc content in the alloy showed a sharp minimum of about 55% atX Zn=55 mol % irrespective of other operating conditions.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1572-8838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Notes: Abstract The partial dissolution of zinc from electrodeposited Ni-Zn alloys (withX Zn 0 =22–87.3 mol %) was studied, in cold and nearly boiling 10m KOH. It was found that alloys withX Zn 0 ≤22 mol % are not dissolved at all. The dissolved zinc fraction,A, increased rapidly with further increase in zinc content and after having passed a maximum withA=82–90% atX Zn 0 =55–58 mol % and a sharp minimum withA=52–65% atX Zn 0 =65–69 mol %, it asymptotically approached toA → 100% atX Zn 0 → 100 mol %. The discontinuous dependence ofA againstX Zn 0 may be explained by differences in the crystallographic composition of the alloy deposits. Alloys withX Zn 0 〈50–60 mol % can be allocated to solid solutions of zinc in the Ni matrix (α-phase); the range of 50–60〈X Zn 0 〈70–80 mol % corresponds to the coexistence of α+γ phases. The pure γ-phase exists within a narrow range atX Zn 0 =75–80 mol %. No zinc dissolution from Ni-Zn alloys withX Zn 0 ≤22 mol % was explained by extremely low zinc activities in dilute solid solutions of the α-phases shifting the Gibbs energy of the dissolution reaction to very low negative, or even to positive values. The dependence of the hydrogen and oxygen overvoltage atj=0.4 A cm−2 in 10m, KOH at 100°C on the original zinc contentX Zn 0 showed, in both cases, a clear minimum atX Zn 0 =75–78 mol %. This points to a practically pure γ-phase in the original Ni-Zn alloy with an approximate composition NiZn3.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1041
    Keywords: Calciumantagonists ; Oesophageal motility ; oesophageal pharmaco-manometry ; lower oesophageal sphincter pressure ; healthy volunteers ; dihydropyridines ; nifedipine ; nifedipine ; nisoldipine ; nitrendipine ; nimodipine ; side ; effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Nifedipine has been proven to be effective and safe in the treatment of primary oesophageal motility disorders which can cause angina-like chest pain and/or dysphagia. The effects of the calcium channel blockers nifedipine, nitrendipine, nimodipine and nisoldipine on oesophageal smooth muscle function in healthy male volunteers were studied by oesophageal manometry using the rapid pull-through-technique, in two randomized, double-blind crossover studies. Lower oesophageal sphincter pressure, oesophageal contraction amplitude and duration after a wet swallow (measured 5 cm and 10 cm above the lower oesophageal sphincter) were determined 30 min before and at 10 minute intervals up to 90 min after the administration of nimodipine and up to 120 min after nifedipine, nitrendipine and nisoldipine. The plasma drug concentration was measured at baseline (−15 min) and in parallel with the manometric measurements. Compared to placebo, lower oesophageal sphincter pressure was significantly decreased by 24% by nifedipine and 17% by nimodipine, whereas the effects of nitrendipine (decrease of 15%) and nisoldipine (9%) were not significant. Nifedipine significantly decreased by 17% the oral contraction amplitude compared to placebo and nimodipine by 11%. The duration of the contraction amplitudes was not altered. The decrease in sphincter pressure was correlated with the corresponding plasma drug levels of nifedipine r=0.92, nitrendipine r=0.80 and nisoldipine r=0.79. Nimodipine showed no such correlation. It is concluded that among the calcium antagonists studied, nifedipine exerted the strongest effect on oesophageal smooth muscle function, so it appears to be the most suitable compound for the treatment of primary motor abnormalities of the oesophagus.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Archives of virology 120 (1991), S. 233-240 
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We present data on the distribution of human immunodeficiency virus (HIV-1) proviral DNA in different subsets of peripheral blood mononuclear cells (PBMCs) over an observation period of eight months. Eleven patients with well documented HIV-1 infection were studied. The PBMCs were obtained at two intervals and purified by fluorescence-activated cell sorting (FACS) after staining with FITC-labelled monoclonal antibodies. Varying numbers of FACS-sorted CD4+ cells, CD8+ cells and peripheral monocytes were assayed for HIV-1 proviral DNA (env andgag region) by PCR. Samples from patients at CDC stages II or III had to contain 103−104 cells in order to allow detection of proviral HIV-1 DNA. At CDC stage IV, however, HIV-1 DNA was detected in as few as 100 CD4+ T-lymphocytes. In contrast, in peripheral monocytes HIV-1 DNA was not regularly found. CD8+ cells did not harbor detectable amounts of proviral DNA. During an observation period of eight months, the rate of infected CD4+ T-lymphocytes increased significantly in three patients while staying constant in the remaining eight patients. This increase of the infection rate was paralleled by clinical progression in one patient and by a decrease of the absolute number of CD4+ cells in another patient. The percentage of CD4+ cells harboring the viral genome increases in the course of the disease. These results may help to explain the decrease in CD4+ T-lymphocyte counts during HIV-1 infection.
    Type of Medium: Electronic Resource
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