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  • 1
    Electronic Resource
    Electronic Resource
    Change in regional cerebral blood flow following glycerol administration predicts (1994)
    Springer
    Acta neurochirurgica 129 (1994), S. 171-176 
    Details
    ISSN: 0942-0940
    Keywords: Cerebral blood flow ; glycerol ; normal pressure hydrocephalus ; shunt surgery ; xenon enhanced computerized tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cerebral haemodynamics were measured in 22 adult patients with secondary normal pressure hydrocephalus (NPH) before and after glycerol administration to determine which patients might benefit from a shunt procedure. Of these 22 patients, 14 were found to be shunt-responsive (group 1) and 8 were shunt-unresponsive (group 2). Measurement of regional cerebral blood flow (rCBF) was performed by xenon-enhanced computerized tomography (XeCT). Clinical factors such as the Evans' index and the presence or absence of brain atrophy, periventricular lucency (PVL), ventricular reflux, stagnation of cerebrospinal fluid on cisternography, and increased intracranial pressure were not statistically significant predictors of shunt responsiveness. Preoperative rCBF values did not differ between groups 1 and 2. The rCBF value in every cerebral region of group 1 patients increased significantly after shunting except for the basal ganglia. On preoperative rCBF measurement, all rCBF values in group 1 significantly increased after glycerol administration except for the periventricular lucency (PVL). Patients in group 2, however, lacked such an increase in rCBF. We therefore propose that, in patients with secondary NPH, shunt surgery will be likely to be effective in those with a demonstrated rise in rCBF after glycerol administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01406498
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  • 2
    Electronic Resource
    Electronic Resource
    Discrepancy of xenon concentrations between end-tidal and blood collection methods in xenon-enhanced computed tomographic measurement of cerebral blood flow (1992)
    Springer
    Neuroradiology 35 (1992), S. 66-68 
    Details
    ISSN: 1432-1920
    Keywords: Xenon-enhanced computed tomography ; End-tidal measurement of xenon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using xenon-enhanced computed tomography for the study of cerebral blood flow, simultaneous measurements of end-tidal and arterial blood xenon concentrations using the blood collection method were performed to investigate the validity of substituting the end-tidal for the arterial blood xenon concentration. Simultaneous measurement by both methods was performed 68 times in 27 patients. There was no statistical correlation between the arterial blood accumulation rate constant obtained by arterial blood and end-tidal samples, nor between the arterial blood saturation value obtained by the two methods, even when correction was made for age. In brain tissue, all parameters calculated using the end-tidal concentration were lower than those using arterial blood. We therefore suggest that cerebral blood flow values calculated using end-tidal xenon concentration are useful only for qualitative cerebral blood flow mapping, and not applicable to absolute values of cerebral blood flow.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00588282
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  • 3
    Electronic Resource
    Electronic Resource
    Crystal structure and hydrogen occupation in H x V2O5(x=0.0–3.9) (1994)
    Springer
    Journal of materials science 29 (1994), S. 1319-1323 
    Details
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Changes in the crystal structure and the lattice constants of powdered crystalline V2O5 after absorption of hydrogen were measured, as a function of the concentration, by X-ray diffractometry. The diffraction spectra obtained showed that three kinds of phases, α (x〈0.4 in H x V2O5), Β (co-existing with either terminal phase in the range of 0.4⩽x〈3.2) and γ (3.2⩽x⩽3.9), appear up tox=3.9, which was found to be the upper limit of the absorption at 70
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00975082
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  • 4
    Electronic Resource
    Electronic Resource
    Electrical conductivity of α-H x V2O5 (X=0.00-0.27): Dependence of hydrogen concentration and orientation (1994)
    Springer
    Journal of materials science 29 (1994), S. 478-481 
    Details
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The dependence of the electrical conductivity, σ, on the hydrogen concentration and crystallographic orientation has been investigated using single crystals of HxV2O5, which were grown by the Bridgeman method and doped with hydrogen within the solid solubility in the α phase by the spillover technique. The temperature dependence of σ showed the feature of diffusive hopping of thermally activated electrons above ∼180 K and variable range hopping below ∼180 K. The dependence of σ on the crystallographic orientation was little different from that of V2O5. The change in σ with the hydrogen concentration was not monotonic; σ increases withx up tox }-0.06, but decreases abovex }-0.06. This behaviour can be explained based on the competition between the increase in the carrier density and the depression of the mobility of carriers with increasingx.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01162510
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  • 5
    Electronic Resource
    Electronic Resource
    Pharmacokinetics, N1-glucuronidation and N4-acetylation of sulfadimethoxine in man (1990)
    Springer
    Pharmacy world & science 12 (1990), S. 51-59 
    Details
    ISSN: 1573-739X
    Keywords: Chromatography, high pressure liquid ; Clearance ; Metabolism ; Pharmacokinetics ; Protein binding ; Sulfadimethoxine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Sulfadimethoxine is metabolized byO-dealkylation, N4-acetylation and N1-glucuronidation. In man, only N1-glucuronidation and N4-acetylation takes place, leading to the final double conjugate N4-acetylsulfadimethoxine-N1-glucuronide. The N1-glucuronides are directly measured by high pressure liquid chromatography. When N4-acetylsulfadimethoxine is administered as parent drug, 30% of the dose is N1-glucuronidated and excreted. Fast acetylators show a shorter half-life for sulfadimethoxine than slow acetylators (27.8±4.2 h versus 36.3±5.4 h; P=0.013), similarly the half-life of the N4-acetyl conjugate is also shorter in fast acetylators (41.3±5.2 h versus 53.5±8.5 h, P=0.036). No measurable plasma concentrations of the N1-glucuronides from sulfadimethoxine are found in plasma. N1-glucuronidation results in a 75% decrease in protein binding of sulfadimethoxine. N4-acetylsulfadimethoxine and its N1-glucuronide showed the same high protein binding of 99%. Approximately 50–60% of the oral dose of sulfadimethoxine is excreted in the urine, leaving 40–50% for excretion into bile and faeces.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01970146
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