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  • 1990-1994  (5)
  • 1
    Electronic Resource
    Electronic Resource
    Amitriptyline Prevents N-Methyl-D-Aspartate (NMDA)-Induced Toxicity, Does Not Prevent NMDA-Induced Elevations of Extracellular Glutamate, but Augments Kainate-Induced Elevations of Glutamate (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 59 (1992), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The effect of amitriptyline on kainate- and N-methyl-D-aspartate (NMDA)-induced toxicity and release of amino acids from cerebellar granule neurons was studied. The ED50 for amitriptyline, imipramine, and nortriptyline protection against NMDA-induced toxicity was 6.9, 6.5, and 1.3 μM, respectively. None of these compounds protected against kainate-induced toxicity. Even though amitriptyline was protective against NMDA-induced toxicity, it had no effect on the NMDA-induced increase in extracellular levels of glutamate or aspartate from these cells, indicating a dissociation between NMDA receptor activation (as indicated by glutamate content elevations) and NMDA-induced toxicity. However, kainate and quisqualate treatment resulted in elevations of glutamate and taurine levels that were further augmented in the presence of 25 μM amitriptyline. These findings confirm the reports of others that tricyclic antidepressants have neuroprotective effects related to the NMDA receptor and expand on these reports by showing that even though there is protection against toxicity, the NMDA receptor is nevertheless activated, suggesting an involvement of these compounds at sites removed from the receptor. Furthermore, this is the first report showing an interaction of tricyclic antidepressants with the function of non-NMDA receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1992.tb09385.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    THE ROLE OF PREDATION IN THE ECOLOGY OF THE RINGED SEAL IN BARROW STRAIT, NORTHWEST TERRITORIES, CANADA (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Marine mammal science 7 (1991), S. 0 
    Details
    ISSN: 1748-7692
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Predation on ringed seals (Phoca hispida) was examined in Barrow Strait between March and May 1984 to 1986. Polar bears were the most important predator. Evidence of bear predation was observed at 18–30% of the ringed seal subnivean structures we located. Ten to 24% of predation attempts were successful, with pups making up 75% to 100% of the seals killed. Bears killed an average of 0.08 to 0.51 seals/km2, which comprised 8 to 44% of the estimated annual pup production. Bears were successful on average in 11.3% of their attempts to kill pups hidden inside birth lairs. On southeast Baffin Island where snow was soft and pups were exposed, bears were successful in 33.5% of their attempts to kill a seal. Negative correlations were found between mean snow depth and predation by polar bears (r= -0.896, P= 0.04, n= 5) in 1985, and between snow depth and the number of predation attempts (r= -0.613, P= 0.02, n= 14) in 1986.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1748-7692.1991.tb00559.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Prospective survey of the use of the laryngeal mask airway in 2359 patients (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 48 (1993), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Patients undergoing anaesthesia in which the laryngeal mask airway was used were prospectively audited over a 6-month period. A simple record sheet was completed at the time of anaesthetic administration and 2359 completed forms were analysed to assess problems encountered with its use. It was used successfully in 2350 patients (99.61%); of these, 1399 patients (59%) breathed spontaneously through the airway and 960 patients (41%) underwent intermittent positive pressure ventilation of the lungs. Two patients (0.08%) were reported to have regurgitated during the use of the laryngeal mask airway, but no serious sequelae associated with its use were encountered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1993.tb06794.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The development ofHepatozoon sipedon sp. nov. (Apicomplexa: Adeleina: Hepatozoidae) in its natural host, the Northern water snake (Nerodia sipedon sipedon), in the culicine vectorsCulex pipiens andC. territans, and in an intermediate host, the Northern leopard frog (Rana pipiens) (1994)
    Springer
    Parasitology research 80 (1994), S. 559-568 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The life cycle ofHepatozoon sipedon sp. nov. was studied in two snake species, the Northern water snake and the Eastern garter snake, in its mosquito hostsCulex pipiens andC. territans, and in the Northern leopard frog. Gametogenesis, fertilization and sporogony occurred within fat body cells in the haemocoel of mosquitoes that had fed on infected water snakes. Mature oocysts averaging 263 μm in diameter and containing more than 500 sporocysts were observed in mosquitoes 28 days post-feeding. Each sporocyst enclosed eight sporozoites. Dizoic cysts were found in the liver of frogs that had been fed infected mosquitoes seven days previously. Two rounds of merogony in various internal organs and intraerythrocytic gamonts were observed in snakes that had been fed frogs which had been orally inoculated with infected mosquitoes. Developmental stages were not seen in snakes that were fed infected mosquitoes directly. A comparison of this life cycle with those described for otherHepatozoon species infecting snakes is presented with reference to the different modes of transmission featured by these parasites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00933003
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Melting and solidification behavior of blends of high density polyethylene with poly(butylene terephthalate) (1993)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 33 (1993), S. 1426-1430 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: This study focuses on the effect of various processing and cooling conditions upon the subsequent melting and solidification behavior of blends of poly(butylene terephthalate) (PBT) and high density polyethylene (HDPE). Differential scanning calorimetry (DSC) measurements have shown that the crystallization of reprocessed PBT is different from the crystallization behavior of virgin samples. Two melting endotherms for PBT were observed for reprocessed PBT and for PBT-PE blends. The nature of each PBT peak is discussed in relation to processing history, solidification conditions, and composition. The presence of two crystallization peaks for the PE component in blends of PE and PBT are thought to be associated with the restriction of molecular motion of PE in the presence of the second component. The relative magnitudes of the two exotherms of PE vary with composition and cooling rate during solidification.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760332108
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    Paper (German National Licenses)
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