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  • 1990-1994  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Effects of Cerebral Ischemia on Regional Dopamine Release and D1 and D2 Receptors (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 60 (1993), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: To expand on the nature of regional cerebral vulnerability to ischemia, the release of dopamine (DA) and dopaminergic (D1 and D2) receptors were investigated in Mongolian gerbils subjected to bilateral carotid artery occlusion (15 min) alone or with reflow (1–2 h). Extracellular cortical and striatal content of DA and its metabolites was measured by microdialysis using HPLC with electrochemical detection. The kinetic properties of D1 and/or D2 receptor binding sites were determined in cortical and striatal membranes with the use of radiolabeled ligands (125I-SCH23982 and [3H]YM-09151-2, respectively). The ischemic release of DA from the striatum was greater (400-fold over preischemic level) than that from the cortex (12-fold over preischemic content). The affinity for the D1-receptor ligand was lower (KD= 1.248 ± 0.047 nM) after ischemia than that for sham controls (KD= 0.928 ± 0.032 nM, p 〈 0.001). The number of binding sites for D2 receptors decreased in striatum (Bmax= 428 ± 18.4 fmol/mg of protein) after ischemia compared with sham controls (Bmax= 510 ± 25.2 fmol/mg of protein, p 〈 0.05). D1 or D2 binding sites were not changed either in the ischemic cortex or postischemic striatum and cortex. The findings strongly suggest that the ischemic release of DA from striatum is associated with early transient changes in D1- and D2-mediated DA neurotransmission.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1993.tb03311.x
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  • 2
    Electronic Resource
    Electronic Resource
    Secretion of Immunoreactive endothelin-1 by capillary and microvascular endothelium of human brain (1992)
    Springer
    Neurochemical research 17 (1992), S. 699-702 
    Details
    ISSN: 1573-6903
    Keywords: Endothelin-1 ; capillaries ; vasoconstrictor peptide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Modulation of immunoreactive endothelin-1 (IR-ET-1) production by vasoactive substances was investigated in cultured endothelial cells (EC) derived from capillaries and microvessels of human brain. Peptides, catecholamines, thrombin, protein kinase C-activating phorbol ester, and calcium ionophore enhanced the secretion of IR-ET-1. The known vasoconstrictive peptides, angiotensin II (Ang II) and arginine-vasopressin (AVP) dose-dependently stimulated the endothelial secretion of IR-ET-1. The angiotensin and vasopressin-inducible production of IR-ET-1 was completely inhibited by their respective receptor antagonists [Sar1, Ala8]-angiotensin II and [1–6 (β-mercapto-β,β-cyclopentamethylene propionic acid), 2-O-methyl-tyrosine]. The results indicate that the peptide-stimulated secretion of IR-ET-1 is receptor-mediated in EC which have specific angiotensin II and arginine-vasopressin receptors. These findings represent the first demonstration of IR-ET-1 production by capillary and microvascular endothelium of human brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00968008
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    Paper (German National Licenses)
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