Electronic Resource
Springer
Cancer and metastasis reviews
11 (1992), S. 21-30
ISSN:
1573-7233
Keywords:
hyaluronan
;
RHAMM
;
directed cell locomotion
;
protein tyrosine phosphorylation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Hyaluronan (HA), a glycosaminoglycan, has long been implicated in cell locomotion. We have shown that HA production regulates the locomotion of H-ras-transformed cells. This autocrine motility mechanism is mediated by a novel HA receptor termed RHAMM, an acronym for Receptor for HA Mediated Motility. HA: RHAMM interactions regulate directional locomotion of tumor cells and result in enhanced protein tyrosine phosphorylation that may be a critical messenger mechanism for initiation of locomotion.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00047600
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