ISSN:
1435-0130
Keywords:
Bovine collagen
;
Porcine collagen
;
Immunological reaction
;
Cellular reaction
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Despite the increasing use of materials containing bovine collagen in plastic surgery, there is a lack of systemic studies on their immunogenic potential, especially when they are used repeatedly. In this paper, it is shown in rats that the second implantation leads to histologically recognizable cellular reaction, the third to clinical symptoms, and after the fourth, there is a much increased reaction. Oral administration of bovine collagen accelerated and increased the reaction. This also holds true for porcine collagen. Antibodies against collagen could be detected in all groups. These results demonstrate that even lyophilized collagen induced strong immunological reactions, which may also occur in the clinical situation, especially since presensitization by the enteral route cannot be ruled out in most cases. This implies that prior to the repeated use of collagen, studies on the specific reactivity pattern of the patient should be performed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00181093
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