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  • 1
    ISSN: 1432-0428
    Keywords: Diabetic neuropathy ; Type 1 (insulin-depend-ent) diabetes mellitus ; Type 2 (non-insulin-dependent) diabetes mellitus ; comparative study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetic patients share many clinical and biochemical characteristics. However, sural nerve biopsies from patients with advanced and chronic neuropathy show ultrastructural differences between these two groups. We investigated whether at a subclinical stage of the illness, when Type 1 and Type 2 diabetic patients are clinically uniform and the histopathological nerve alterations are not advanced, comparison between the two diabetes groups might show differences in nerve fibre involvement related to the different pathogeneses of the neuropathies. A total of 88 diabetic patients (52 Type 1 and 36 Type 2), with a subclinical form of polyneuropathy were selected. The clinical neurophysiological examination consisted of motor and sensory nerve conduction studies, Hoffmann (H)-reflex, single fibre electromyography and static as well as dynamic pupillometry. With regard to clinical neurophysiological abnormalities, the severity of the polyneuropathy appeared to be equal in both groups. Despite the absence of clinical symptoms the neurophysiological abnormalities were pronounced and it was impossible to differentiate Type 1 diabetic patients from Type 2 diabetic patients on a clinical neurophysiology basis when correcting for differences in age, height, and duration of illness. In the Type 1 diabetic group as well as in the Type 2 diabetic group the autonomic nerve fibres and nerves in the legs were more frequently affected than the thick myelinated nerves in the arms. These findings do not support the assumption that there is a difference in the manifestation of polyneuropathy between Type 1 and Type 2 diabetic patients.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 40 (1991), S. 17-21 
    ISSN: 1432-1041
    Keywords: Hyperventilation ; normal subjects ; quantitative EEG ; cerebral blood flow ; nimodipine ; cerebral ischaemia ; side effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The anti-ischaemic properties of nimodipine 30 mg and 60 mg t.i.d. for 4 days has been tested in a double-blind, placebo-controlled, cross-over study based on the use of hyperventilation to reduce flow velocity in cerebral arteries. Whether the anti-ischaemic properties were due to a vasodilatator action on cerebral blood vessels or to an anti-ischaemic effect on cerebral neurons was studied. There was a slight cardiovascular effect, without any significant change in the EEG at rest. During standardized hyperventilation, there was no difference in the reduction in the blood flow velocity in the nimodipine and placebo groups (namely 56%, 56% and 59%). Both doses of nimodipine, however, significantly attenuated the hyperventilation-induced increase in slow EEG activity in the 1.5–6.0 Hz range. It is concluded that the anti-ischaemic properties of nimodipine are due to an effect on the central nervous system rather than to an effect on cerebral blood flow.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    GeoJournal 24 (1991), S. 71-76 
    ISSN: 1572-9893
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography
    Notes: Abstract Coastal research is structured here according to its main topics, and remote sensing systems are valued accordingto their usefulness for these different topics. Mainly, coastal research requires a high spatial resolution in combination with a high temporal resolution power. Therefore, satellite-borne systems are less suited than airborne systems. High altitude photography combines advantages of both systems, but substances may best be detected by non-photographic techniques.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-5036
    Keywords: phosphate ; root carbohydrate content ; soybean ; uptake efficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract The carbohydrate levels in the roots of two soybean cultivars (Century, Woodworth) were determined during the early vegetative growth stage. Based on Michaelis-Menten kinetics Century was characterized as being more efficient at phosphate uptake when compared to Woodworth. The experiments were carried out at normal nutrition (+P treatment) as well as under a condition of moderate phosphate stress (−P treatment). The stress situation was created by withdrawal of phosphate from the nutrient solution for five or nine days. Compared to the +P-treatment the deprivation of phosphate led to a reduction of more than 50% in the phosphate content of the plant tissue. The carbohydrates in the roots exhibited differences between both cultivars with Century generally having higher sucrose levels. During the morning the +P treatment of Century exhibited ≈ 10 mg g-1 and in the afternoon ≈ 16 mg g-1 sucrose (plant dry weight basis). This compares to ≈ 8 mg g-1 sucrose (morning) and ≈ 13 mg g-1 sucrose (afternoon) for Woodworth. Phosphate stress increased the levels of hexoses (glucose, fructose) in both varieties significantly. The sucrose levels remained higher for the Century variety even during phosphate stress. We conclude that the shoot of the Century variety supplies its root with an increased amount of energy in form of carbohydrates compared to the Woodworth variety. This may enable the plant to take up phosphate more efficiently. It is also remarkable that the Century variety reduces the pH of the nutrient medium more rapidly. This active proton deposition may create a high membrane potential which is known to be necessary for phosphate uptake.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Plant and soil 123 (1990), S. 139-145 
    ISSN: 1573-5036
    Keywords: P efficiency ; 32P/33P labelling ; P redistribution ; P solubility ; sorghum genotypes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract With two sorghum cultivars differing in P efficiency a P uptake experiment (32P/33P labelling) was carried out followed by a period of P deficiency. The tendency of the total P distribution and redistribution pattern was rather similar in both sorghum cultivars. Although in the cultivar with a greater P absorbing capacity per unit root weight a higher proportion of the P was found in the inorganic P soluble fraction this is not necessarily an indication of a higher vacuolar affinity for P. Under P deficiency in both cultivars a rapid decrease of the TCA soluble P fraction in the leaves was observed. Before complete exhaustion of this fraction the TCA insoluble P fraction was also markedly reduced. In the roots the total P content was maintained fairly constant with a distinct shift in favour of the insoluble fraction occurring during the period of P deficiency. It is assumed that in the P efficient sorghum cultivar producing more dry matter per increment of P absorbed, rather inherent growth promoting factors contribute to the intraspecific P efficiency by a stimulation of the intensity of P redistribution and thus compensate for the lower P absorbing capacity of its roots.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1573-2568
    Keywords: evoked potentials ; esophageal balloon distension ; brain mapping ; insula
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to obtain insight in the generator localization of esophageal evoked potentials, cerebral responses were recorded from 32 scalp electrodes in five healthy volunteers (two male; three female; age 20–30 years), using series of 50 balloon inflations with 15 ml of air. Sequential topographical mapping of waveforms was performed in each subject. Biphasic waveforms were recorded. At Fpz, a positive deflection at 300 and a negative deflection at 465 msec (P300 and N465) were recorded and at Pz, N300 and P465. At Cz the first peak (N270) was slightly earlier than 300 msec. Waveforms were left to right symmetrical. At distal electrodes, biphasic waveforms were recorded (P300 and N465). In four subjects, a gradual phase shift occurred in between the waveforms at midline electrode Cz and the left and right mastoids. Brain mapping showed phase reversals between central negativity and surrounding positivity at about 300 msec, and between central positivity and surrounding negativity at 400–500 msec. Our data suggest the presence of more than one generator in the anterior and dorsal part of the insula and/or dorsal periinsular cortex.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1573-6792
    Keywords: Median nerve SEP ; Dipoles ; Infarct ; Stimulus rate ; Dipole attenuation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In normal subjects and patients with sensory, sensorimotor or motor deficit, due to a unilateral infarct affecting the thalamocortical radiation, SEPs to median nerve stimulation were analyzed by a spatiotemporal dipole model which describes an evoked potential by a limited number of stationary dipoles with time varying amplitudes. In the normal subjects the SEPs were explained by one dipole in the brainstem and two dipoles in the cortical hand area contralateral to stimulation, all with different time courses. Increasing the stimulus rate to 6.2 Hz yielded a reduction of the moment of both cortical dipoles but hardly affected brainstem dipole moment. In the five patients with sensory or sensorimotor deficit the strength of one or both cortical dipoles was reduced on the side of the lesion. In the patients with pure motor deficit cortical dipole activity was normal. The brainstem dipole was preserved in all patients.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1573-6792
    Keywords: CT ; Dipole ; EEG ; Epilepsy ; Multimodality Matching ; MEG ; MRI ; Volume Visualization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Interpretation of EEG (electroencephalography) or MEG (magnetoencephalography) derived three-dimensional dipole localizations is hampered by poor visualization. This paper describes a method for combining dipole data with structural image data of the same patient. To ensure high precision this method utilizes external markers that are easy to apply. These markers can achieve subslice accuracy and can even be used to pinpoint reference points outside the scanned volume. Accurate matching is thus provided even in standard imaging protocols employing thick slices and/or large interslice gaps. The results of the matching method are presented in 2D and 3D visualizations. The hybrid images facilitate the interpretation of dipole localizations with respect to the patient's anatomy.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Brain topography 5 (1993), S. 203-213 
    ISSN: 1573-6792
    Keywords: Rolandic spike ; Double spike phenomenon ; Dipole source analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Dipole source analysis of rolandic spike-and-wave complexes was performed in 48 children. The estimated source of the rolandic spike, of the trough between the spike and the following slow wave, and of the slow wave appeared to have the same position but had a small significant difference in orientation. Despite the heterogeneity of associated clinical syndromes, there were no clear differences between the clinical categories of patients regarding the localization and the orientation of the sources of the rolandic spike, trough and slow wave. The presence of a second source could explain the ascending phase of the rolandic spike in 19 children. This combination of two sources corresponded with the "double-spike phenomenon" that had been found previously by sequential brain mapping and which was associated with epilepsy. The preceding spike source and the source of the rolandic spike-and-wave complex were found to have the same position but a different orientation. A hypothetical explanation is proposed in which the presence of the rolandic spike-and-wave complex alone is insufficient to account for the clinical symptomatology. Both the preceding spike source and the source of the rolandic spike-and-wave complex, representing two separate, nearby but differently oriented populations of neurones in the inferior part of the rolandic cortex, is necessary for the development of epileptic manifestations.
    Type of Medium: Electronic Resource
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