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  • Electronic Resource  (21)
  • 1985-1989  (15)
  • 1970-1974  (6)
  • 1
    Electronic Resource
    Electronic Resource
    Complexation of fibronectin with tissue transglutaminase (1989)
    s.l. : American Chemical Society
    Biochemistry 28 (1989), S. 628-635 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00428a032
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  • 2
    Electronic Resource
    Electronic Resource
    Nuclear magnetic resonance study of acid-base interactions for the chloranil electrode system in acetonitrile (1972)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 76 (1972), S. 246-248 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j100646a018
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  • 3
    Electronic Resource
    Electronic Resource
    The Marl Slate: a model for the precipitation of calcite, dolomite and sulphides in a newly formed anoxic sea (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Sedimentology 34 (1987), S. 0 
    Details
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Detailed studies of a new, complete Marl Slate core in South Yorkshire have provided information on isotopic (δ13C, δ18O, δ34S) and geochemical variations (trace elements and C/S ratio) which enable the formulation of a model for carbonate and sulphide precipitation in the Late Permian Zechstein Sea. Calcite and dolomite are intimately associated; the fine lamination, organic character and absence of benthos in the sediments are indicative of anoxic conditions. Lithologically the core can be divided into a lower, predominantly sapropelic Marl Slate (2 m) and an upper Transition Zone (0·65 m) of alternating sapropel and calcite-rich and dolomite-rich carbonates.C/S ratios are 2·22 for the Marl Slate and 1·72 for the Transition Zone respectively, both characteristic of anoxic environments. δ18O in the carbonates shows a large and systematic variation closely mirrored by variations in calcite/dolomite ratio. The results suggest a fractionation factor equivalent to a depletion of 3·8% for 18O and 1·5% for 13C in calcite. The δ34S values of pyrite are isotopically light (mean value = - 32·7%) suggesting a fractionation factor for the Marl Slate of almost 44%, typical of anoxic basins.The results are related to stratification in the early Zechstein Sea. Calcite was precipitated in oxic upper layers above the halocline. Below the oxic/anoxic boundary framboidal pyrite was precipitated, resulting in lower sulphate concentration and elevated Mg/Ca ratio (due to calcite precipitation). As a result of this, dolomite formation occurred below the oxic/anoxic interface, within the anoxic water column and in bottom sediments. Variations in calcite/dolomite ratios, and isotopic variations, are thus explained by fluctuations in the relative level of the oxic/anoxic boundary in the Zechstein Sea.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3091.1987.tb00558.x
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  • 4
    Electronic Resource
    Electronic Resource
    Ultrastructure of Synaptic Vesicle Formation in Cerebral Cortex (1973)
    [s.l.] : Nature Publishing Group
    Nature 242 (1973), S. 57-59 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1 Cortex extracellular space is filled with electron dense reaction product of horseradish peroxidase (HRP) 1 h after sub-arachnoid application. Presynaptic terminals show many of their synaptic vesicles filled with tracer and two vesicles (arrows) are intimately associated with the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/242057a0
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  • 5
    Electronic Resource
    Electronic Resource
    Root squaring using level-index arithmetic (1989)
    Springer
    Computing 43 (1989), S. 171-185 
    Details
    ISSN: 1436-5057
    Keywords: 65G99 ; 65H05 ; Level-index ; symmetric level-index ; root-squaring ; polynomial equations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Zusammenfassung Das “symmetrische Höhenindexsystem” (sli) zur Zahlendarstellung vereinfacht die Überwachung der Rechengenauigkeit und vermeidet overflow—oder underflow—Probleme. In dieser Arbeit werden die praktischen Vorzüge des Systems am Beispiel des Graeffeverfahrens vorgeführt.
    Notes: Abstract The symmetric level-index,sli, system for representing numbers eases the monitoring of precision while avoiding the problems associated with overflow and underflow. In this paper the practical benefits of the system are displayed, using the root-squaring method of Graeffe as a vehicle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02241860
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  • 6
    Electronic Resource
    Electronic Resource
    Small is beautiful (1988)
    [s.l.] : Nature Publishing Group
    Nature 334 (1988), S. 392-392 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] To ANY molecular biologist who has the time to reflect, it will no doubt seem surprising that only a decade ago we were (blissfully?) unaware of the existence of the intervening sequences that are present in many of the genes of eukaryotic cells. What seems all the more amazing is how far we have ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/334392b0
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  • 7
    Electronic Resource
    Electronic Resource
    A study of the influence of pH on the buccal absorption and renal excretion of procainamide (1974)
    Springer
    European journal of clinical pharmacology 7 (1974), S. 287-289 
    Details
    ISSN: 1432-1041
    Keywords: Procainamide ; buccal absorption ; renal excretion ; urine ; pH
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The buccal absorption of procainamide was studied in 4 normal, male volunteers over a pH range of 5–11. In another investigation the same 4 volunteers collected their urine for 24 h after taking 250 mg of procainamide hydrochloride orally on 3 separate occasions, during which urine pH was uncontrolled, acidified by ammonium chloride ingestion or alkalinised by sodium bicarbonate ingestion. The procainamide remaining after buccal absorption and present in the urine samples was determined spectrophotometrically. It was found that neither the buccal absorption nor the renal excretion of procainamide was substantially altered by changes in pH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00560346
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  • 8
    Electronic Resource
    Electronic Resource
    The relationship between theophylline clearance and age in adult life (1989)
    Springer
    European journal of clinical pharmacology 36 (1989), S. 29-34 
    Details
    ISSN: 1432-1041
    Keywords: theophylline ; asthma ; clearance ; age ; adults ; elderly ; normal subjects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Fifty three subjects (31 normal volunteers and 22 patients with asthma) between the ages of 20 and 87 years had their theophylline clearance measured. Volume of distribution (V) and terminal elimination half-life (t1/2) were also calculated in the volunteers who received i.v. theophylline. Although patients tended to have higher clearance values than volunteers, in both groups the oldest third had the lowest clearances. For the combined group (corrected for the patient effect) the oldest third (mean age 70 years) had a mean clearance of 0.53 versus 0.72 for the middle third (mean age 47 years) and 0.73 ml/min/kg CBW for the youngest third (mean age 26 years). There was no statistically significant age related change in V/kg CBW but t1/2 did rise with increasing age. Thus, although clearance does not fall with increasing age during younger adult life, there is a fall during late adult life becoming apparent in the seventh, eighth and ninth decades.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561019
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  • 9
    Electronic Resource
    Electronic Resource
    Effect of captopril on skin blood flow following intradermal bradykinin measured by laser Doppler flowmetry (1989)
    Springer
    European journal of clinical pharmacology 37 (1989), S. 471-475 
    Details
    ISSN: 1432-1041
    Keywords: bradykinin ; captopril ; laser Doppler flowmetry ; weal ; flare ; skin blood flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of captopril on skin response to intradermal injection of bradykinin was investigated by laser Doppler flowmetry (LDF) and weal and flare measurements in this randomised, double-blind, placebo-controlled, cross-over balanced study. Intradermal injections of 1 and 2.5 µg of bradykinin and normal saline were made into the forearm skin of six healthy volunteers between 1 and 2 h (t1) and between 3 and 4 h (t2) after either 25 mg captopril or placebo. Skin blood flow outside the induced weal was monitored continuously by LDF for 15 min and the mean LDF values over the last 15 s were used for analysis. Weal and flare sizes were measured at 15 min. On the placebo days, the mean LDF output, weal volume and flare area increased with incremental bradykinin dose. Pre-treatment with captopril significantly increased LDF output following intradermal bradykinin at t1 but not at t2. At both t1 and t2, captopril significantly increased weal volume. There was no significant difference between treatments in flare areas. Skin response following intradermal normal saline, measured by the above parameters, was not affected by captopril. This study showed that captopril potentiated the effects of intradermal bradykinin both with respect to blood flow changes and weal formation. The non-invasive technique of LDF can be used to detect the skin blood flow changes induced by intradermal bradykinin and the potentiation of this effect by captopril. It appears to be a useful and more objective method of quantifying local cutaneous blood flow changes than measurement of flare area.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558126
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  • 10
    Electronic Resource
    Electronic Resource
    A comparison of the haemodynamic effects of nifedipine, nisoldipine and nitrendipine in man (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 393-397 
    Details
    ISSN: 1432-1041
    Keywords: nifedipine ; nisoldipine ; nitrendipine ; haemodynamics ; adverse effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Nifedipine (10 mg), nisoldipine (10 mg) and nitrendipine (20 mg) were given orally to 8 normal volunteers in a placebo controlled, double blind, crossover study. Blood pressure (BP), pulse (P) and systolic time intervals (STI) were recorded at time 0, 30, 60, 90, 120 min after drug administration. Adverse effects were also recorded. There was a fall in BP, pre-ejection time (PEP), PEP/LVET (left ventricular ejection time) and electro-mechanical systole index (QS2 index), and a rise in LVET index in response to the three active drugs compared with placebo. All active drugs, but not placebo, were associated with adverse effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00607950
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