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  • Digitale Medien  (3)
  • 1985-1989  (3)
Datenquelle
Materialart
  • Digitale Medien  (3)
Erscheinungszeitraum
Jahr
  • 1
    Digitale Medien
    Digitale Medien
    Antitumor action of N-(2-chloroethyl)-N-nitrosocarbamoyl derivatives of biologically active polypeptide hormone fragments (1986)
    Springer
    Cancer chemotherapy and pharmacology 16 (1986), S. 129-132 
    Details
    ISSN: 1432-0843
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The antitumor action of the 2-chloroethylnitrosocarbamoyl derivatives of peptides related to the 9–13 amino acid residues of α-MSH/ACTH and of the C-terminal tetrapeptide analogue of gastrin have been investigated. Series of 2-chloroethylnitrosoureas attached to amino acids, di-, tri-, tetra-, or pentapeptides were examined in a primary screening system. Among these compounds the Pro-Val-, Lys-Pro-Val-, and Trp-Gly-Lys-Pro-Val-containing 2-chloroethylnitrosocarbamoyl groups were the most effective in the L1210 system. The human melanoma xenograft line was also affected by these agents, while colorectal xenografts were insensitive. A combination of tripeptide-2-chloroethyl-nitrosourea with BCNU induced more than additive growth inhibition of L1210 leukemia.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00256162
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  • 2
    Digitale Medien
    Digitale Medien
    Comparative study on Lewis lung tumour lines with ‘low’ and ‘high’ metastatic capacity III. Glycosaminoglycan synthesis, transport and degradation in cell lines (1989)
    Springer
    Clinical & experimental metastasis 7 (1989), S. 659-669 
    Details
    ISSN: 1573-7276
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The glycosaminoglycans (GAGs) of low (LM) and highly metastatic (HM) cell lines of the Lewis lung tumour (3LL) were compared using [3H]glucosamine labelling techniques. The GAGs isolated from nuclei, cytoplasm, pericellular fractions and medium were analysed by cellulose acetate electrophoresis and by digestion with specific enzymes, and the following conclusions were drawn. 1. Increased cellular uptake and incorporation of [3H]glucosamine into glycoconjugates of the cytoplasm was a typical feature of the highly metastatic cell line after a 48-h labelling. However, there was no elevated radioactivity in glycolipids. 2. Radioactivity of the purified GAGs was two and three times higher in nuclear and cytoplasmic fractions of HM cells than in those of LM cells. There was much less difference between the two cell lines in the pericellular fractions. 3. A definite change from chondroitin sulphate to dermatan sulphate dominancy was recorded in each GAG fraction. Higher heparan sulphate labelling was observed in the cytoplasmic and pericellular GAGs of HM cultures. 4. In the post-labelling period about three times more GAG was present in the extracellular compartment of the HM cultures compared with the LM cultures. 5. In the LM cultures the total GAG-associated radioactivity decreased by 73 per cent in the 48-h chase period whereas in the HM cultures it decreased by only 30 per cent. This indicates a higher rate of GAG degradation in the LM cultures.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01753676
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  • 3
    Digitale Medien
    Digitale Medien
    Comparative study on Lewis lung tumor lines with ‘low’ and ‘high’ metastatic capacity. II. Cytochemical and biochemical evidence for differences in glycosaminoglycans (1987)
    Springer
    Clinical & experimental metastasis 5 (1987), S. 79-87 
    Details
    ISSN: 1573-7276
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The enhanced metastatic capacity of an in vivo selected Lewis lung tumor line (LLT-HH) was correlated with changes in cell-associated glycosaminoglycans (GAG) using ultrastructural cytochemistry, flow cytometry and biochemistry. The increase in highly sulphated GAG content on the cell membrane of LLT-HH cells compared to the parent LLT cells was demonstrated cytochemically. Using in vitro [3H]glucosamine labelling of GAG components it was shown that the LLT-HH cells were characterized by a high production of heparan sulphate while the parent LLT line had a high hyaluronic acid-chondroitin sulphate production. The high metastatic phenotype is accompanied by an altered production of cell-associated GAGs.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00116628
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