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Digitale Medien

Expression of occludin in human rectal carcinoid tumours as a possible marker for glandular differentiation (2004)

Tokunaga, Y ; Tobioka, H ; Isomura, H ; [weitere]

Oxford, UK : Blackwell Science Ltd

Histopathology 44 (2004), S. 0

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ISSN: 1365-2559

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: Aims: To examine whether or not the tight junction-associated transmembrane protein occludin is expressed in rosette or gland-like structures in human rectal carcinoid tumours. The tight junction is crucial for the formation and maintenance of organized tubular structures in glandular epithelia. Previous studies have reported the presence of glandular structures in carcinoid tumours, though they are not believed to arise from glandular epithelium.Methods and results: The expression profiles of occludin in 40 carcinoid tumours were examined immunohistochemically, using an anti-occludin monoclonal antibody. In eight (20%) samples of typical carcinoid tumours, a small number of rosette-like tubular structures outlined by occludin were detected.Conclusions: Tight junction-associated molecules, including occludin, are thought to be one of the most characteristic structural markers of polarized glandular structures. The results of the present study provide supportive evidence that carcinoid tumour cells are capable of glandular differentiation.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.0309-0167.2003.01807.x

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Digitale Medien

Gondo, K. ; Kira, R. ; Tokunaga, Y. ; [weitere]

Springer

Pediatric radiology 30 (2000), S. 866-868

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ISSN: 1432-1998

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract We report a case of giant congenital melanocytic nevi (GCMN) at risk of developing neurocutaneous melanosis (NCM) with age-related changes observable on MRI of the brain. However, although the usefulness of MR imaging in NCM is well known, age-related changes on MRI have rarely been reported. The prevalence of positive MRI findings and prognosis in GCMN accompanied by epilepsy and/or mental retardation awaits clarification. This case report may suggest the importance of serial brain MRI in cases of GCMN in assessing the risk of NCM.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/s002470000348

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Digitale Medien

Influence of hypoxia on mitochondrial function and energy status in CCl4-induced cirrhotic rat liver (1989)

Wakashiro, S. ; Shimahara, Y. ; Ikai, I. ; [weitere]

Springer

Research in experimental medicine 189 (1989), S. 153-161

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ISSN: 1433-8580

Schlagwort(e): Rat ; Liver cirrhosis ; Hypoxia ; Redox state ; Mitochondrial oxidative phosphorylative activity

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary The influence of hypoxia on hepatic mitochondrial function and energy status was studied in normal and carbon tetrachloride (CCl4)-induced cirrhotic rats. Under hypoxemia of 50 mm Hg-PaO2, hepatic energy status was suppressed both in normal and cirrhotic rats. After the reversal of hypoxia, it was completely restored in normal rats concomitant with a rapid elevation of hepatic mitochondrial redox state (overshoot phenomenon) and increase in the mitochondrial oxidative phosphorylative activity. By contrast, in cirrhotic rats, such an enhancement of mitochondrial function was not observed. It was clarified that cirrhotic liver mitochondria have little capacity to respond to the hypoxic stress. A lower resistance to hypoxic episode in cirrhotics might be attributable to the absence of mitochondrial enhancement which is a compensatory mechanism for the deranged energy metabolism of the liver.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01852163

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Digitale Medien

Corrosion of silicon nitride ceramics in aqueous HF solutions (1988)

Sato, T. ; Tokunaga, Y. ; Endo, T. ; [weitere]

Springer

Journal of materials science 23 (1988), S. 3440-3446

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ISSN: 1573-4803

Quelle: Springer Online Journal Archives 1860-2000

Thema: Maschinenbau

Notizen: Abstract The leaching behaviours of hot-pressed Si3N4 ceramics containing Y2O3, Al2O3 and AIN as additives and hot isostatically pressed Si3N4 without additives were studied in 0.1 to 10 M HF aqueous solutions at 50 to 80° C. Silicon and aluminium ions were dissolved into the HF solutions, but yttrium ion did not dissolve at all and formed insoluble YF3. The dissolution of silicon and aluminium ions was controlled by the surface chemical reaction and the apparent activation energies were 70.5 to 87.6 kJ mol−1, respectively. The corrosion rate increased with increasing degree of crystallization of the grain boundary phases. The corrosion resulted in roughness of the surface and degradation of the fracture strength. Si3N4 ceramics containing an amorphous phase at the grain boundaries showed the most excellent resistance to corrosion with HF solution, and kept a fracture strength of above 400 M Pa even after leaching 40% of the silicon ions.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00540476

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