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  • 1
    Digitale Medien
    Digitale Medien
    Effects of hypophysectomy on soleus muscle fibers and spinal motoneurons in rats (1995)
    Springer
    Acta neuropathologica 89 (1995), S. 204-208 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Muscle fiber type distribution ; Oxidative enzyme activity ; Soleus muscle ; Spinal motoneuron ; Hypophysectomy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The fiber type distribution of the soleus muscle in male and female rats was investigated 4 weeks after hypophysectomy. Oxidative enzyme activity of the soleus motoneurons in the spinal cord was also examined by enzyme histochemical assay. In male rats, the total number of fibers in the soleus muscle was not changed after hypophysectomy, but the percentage of intermediate (INT) fibers (with intermediate adenosine triphosphatase activity following alkaline preincubation, and high succinate dehydrogenase and α-glycerophosphate dehydrogenase activities) was increased. All types of fibers in the soleus muscle of hypophysectomized rats showed high adenosine triphosphatase activity following acid preincubation. Oxidative enzyme activity of the motoneurons innervating the soleus muscle was not changed after hypophysectomy. Similar results were obtained in female rats. It is suggested that the increased percentage of INT fibers in the rat soleus muscle after hypophysectomy is due to a lack or reduced levels of growth hormones, and that the metabolic capacities of the muscle fibers and of the innervating motoneurons are affected independently by hypophysectomy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00309335
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  • 2
    Digitale Medien
    Digitale Medien
    Differential effects of methylmercury on the synthesis of protein species in dorsal root ganglia of the rat (1989)
    Springer
    Archives of toxicology 63 (1989), S. 226-230 
    Details
    ISSN: 1432-0738
    Schlagwort(e): Methylmercury ; Protein synthesis ; Dorsal root ganglion ; Two-dimensional electrophoresis ; Rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Dorsal root ganglia from control and methylmercury(MeHg)-treated rats were incubated in vitro with 35S-methionine ant the proteins synthesized were analyzed by two-dimensional electrophoresis. The double labelling method, in which proteins of control dorsal root ganglia labelled in vitro with 3H-leucine were added to each of the two samples as an internal standard, was used to minimize unavoidable errors arising from the resolving procedure itself. The results obtained showed that the effect of MeHg on the synthesis of proteins in dorsal root ganglia was not uniform for individual protein species in the latent period of MeHg intoxication. Among 200 protein species investigated, 157 showed inhibition of synthesis close to that of the total proteins in the tissue (68% of the control). Among the remaining protein species, 20 showed real stimulation of synthesis, whereas 7 were moderately inhibited and 16 were inhibited more strongly than the total proteins in the tissue. These results suggest that the effect of MeHg on the synthetic rates for protein species in dorsal root ganglia differs with the species, and that unusual elevation or reduction of the synthesis of some protein species caused by MeHg may lead to impairment of normal nerve functions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00316373
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  • 3
    Digitale Medien
    Digitale Medien
    Improved therapeutic effects of interleukin 2 after the accumulation of lymphokine-activated killer cells in tumor tissue of mice previously treated with cyclophosphamide (1988)
    Springer
    Cancer immunology immunotherapy 26 (1988), S. 250-256 
    Details
    ISSN: 1432-0851
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We investigated the combined effects of human recombinant interleukin 2 (IL-2) and cyclophosphamide (CY) on s.c. transplanted 3LL lung carcinoma in C57BL/6 mice. A total of 95% of the tumors were competely cured when CY (150 mg/kg, i.v.) was given on day 5 (5 days after tumor implantation) and IL-2 (5×104 Jurkat Units/day, i.p.) was then combined with it between day 6 and day 15. CY alone brought about the complete regression of tumors, although 60% of the mice died of local recurrence and pulmonary metastasis; IL-2 alone had no therapeutic effect. Satisfactory effects from the combination of CY and IL-2 were also obtained by 5 days administration of IL-2 between days 11 and 15, initiated 6 days after CY treatment, but not by that given before CY (days 1–5) or 1 day after CY (days 6–10). No therapeutic effects from IL-2 were observed when it was combined with other types of chemotherapy that showed not therapeutic effects by themselves. Nor were we able to observe any transplantation resistance to the rechallenge of 3LL tumor in cured mice. We particularly examined the lymphokine-activated killer (LAK) cells as we suspected that these were responsible for the development of active effector cells in the treated mice. LAK cell activity in fresh spleen cells was detected in mice treated with IL-2 alone but not in untreated mice nor in those treated with CY alone or CY plus IL-2. The number of LAK precursor cells in the spleen had increased on day 8 and on day 13 in untreated mice with 3LL, as compared with the incidence in normal mice, while the number of cells had decreased by day 18. On the other hand LAK precursor cells were suppressed on day 8 and tended to recover thereafter in CY-treated mice. Adoptively transferred LAK cells were found to accumulate in CY-treated tumors 2.5 times more densely than in untreated tumors. The preferential accumulation of LAK cells that had been activated systemically by the appropriately timed administration of IL-2 in tumor tissue was followed by the improved effects obtained by combined treatment with CY and IL-2.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00199937
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  • 4
    Digitale Medien
    Digitale Medien
    Effects of hypobaric hypoxia on histochemical fibre-type composition and myosin heavy chain isoform component in the rat soleus muscle (1995)
    Springer
    Pflügers Archiv 429 (1995), S. 601-606 
    Details
    ISSN: 1432-2013
    Schlagwort(e): Hypobaric hypoxia ; Histochemistry ; Muscle fibre-type ; Electrophoresis ; Myosin heavy chain isoform ; Soleus muscle ; Rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Histochemical fibre-type composition and myosin heavy chain isoform component in the soleus muscle were studied in normoxic rats at postnatal ages of 5, 10, 15, and 20 weeks and in rats exposed to hypobaric hypoxia (460 torr) for 5 weeks from postnatal ages of 5, 10, and 15 weeks. The increase in the percentage of type I fibres and the concomitant decrease in that of type IIa fibres in the soleus muscle of normoxic rats were observed until 15 weeks of age. On the other hand, no change in the fibre-type composition of the muscle during postnatal development was observed in hypoxic rats, irrespective of the age at which they were exposed to hypoxia. The changes in the myosin heavy chain isoform component (MHC I and MHC IIa) of the muscle during postnatal development and by hypoxia corresponded well with those in the muscle fibre-type composition. It is concluded that hypobaric hypoxia inhibits the growth-related shift of muscle fibre-types from type IIa to type I and of myosin heavy chain isoforms from MHC IIa to MHC I in the rat soleus muscle, and that there are no changes in the muscle fibre-type composition or the myosin heavy chain isoform component caused by hypoxia after the shifts in these parameters which occur during postnatal development are completed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00373980
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  • 5
    Digitale Medien
    Digitale Medien
    Beryllium in sediments of Nagoya harbor estuaries (1986)
    Springer
    Bulletin of environmental contamination and toxicology 36 (1986), S. 935-941 
    Details
    ISSN: 1432-0800
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Energietechnik , Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01623608
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  • 6
    Digitale Medien
    Digitale Medien
    Levels and ages of selenium and metals in sedimentary cores of Ise Bay as determined by 210-Pb dating technique (1987)
    Springer
    Bulletin of environmental contamination and toxicology 39 (1987), S. 214-223 
    Details
    ISSN: 1432-0800
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Energietechnik , Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01689409
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  • 7
    Digitale Medien
    Digitale Medien
    Separation and determination of selenium(IV) in environmental water samples by an anion-exchange resin modified with bismuthiol-II and diaminonaphthalene fluorophotometry (1985)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 321 (1985), S. 56-60 
    Details
    ISSN: 1618-2650
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Summary Selenium(IV) in environmental water samples was determined fluorometrically following its collection by the use of a new functional resin. The resin was easily prepared from an anion-exchange resin by modification with bismuthiol II. A highly selective adsorption of selenium(IV) was achieved by the formation of stable selenotrisulfide from bismuthiol II and selenium(IV) on the resin. The method was successfully employed for the determination of Se in river water and waste water.
    Notizen: Zusammenfassung Das Selen wurde mit Hilfe eines mit Bismuthiol II modifizierten Anionenaustauschers angereichert und fluorometrisch bestimmt. Die Adsorption, die auf der Bildung eines stabilen Selentrisulfids beruht, ist sehr selektiv. Das Verfahren wurde mit gutem Erfolg zur Selenbestimmung in Fluß- und Abwasser eingesetzt.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00464487
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  • 8
    Digitale Medien
    Digitale Medien
    Determination of selenium in sediments by hydride generation atomic absorption spectrometry. Elimination of interferences (1988)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 330 (1988), S. 600-604 
    Details
    ISSN: 1618-2650
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary The hydride generation/atomic absorption spectrometry (AAS) with an automated flow system is useful for the routine analysis of selenium in environmental samples. This method is, however, subject to interferences from transition metal ions and other hydride forming ions. The conditions to minimize the interferences were established: the concentration of hydrochloric acid 6 mol/l; the concentration of tetrahydroborate 0.5%. Iron(III) chloride released the depression of selenium signals by metal ions such as copper(II) and bismuth(III). Selenium in several standard reference materials including sediment samples was determined by the present method and by fluorimetry with 2,3-diaminonaphthalene. The results obtained by the two methods agreed with an acceptable precision. This means that hydride generation/AAS offers good precision and accuracy in the determination of selenium in sediment samples as well as DAN fluorimetry. However, the former is much simpler in operation. The method was applied to the determination of selenium in estuarine sediments collected in Nagoya harbor and Ise Bay. The results can be used to assess the pollution state of these places.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00473775
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  • 9
    Digitale Medien
    Digitale Medien
    Determination of selenium in sediments by fluorimetry with 2,3-diaminonaphthalene after an improved pretreatment by tellurium coprecipitation (1986)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 325 (1986), S. 539-543 
    Details
    ISSN: 1618-2650
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Summary An improved fluorimetric method for the determination of selenium in estuary sediments and sedimentary core samples is described. For the separation of selenium, coprecipitation with tellurium-ascorbic acid method gave satisfactory results. The status of the pollution caused by selenium in Nagoya area, which is one of the most industrially active areas in Japan, was estimated, based on the results obtained with this method. Several μg/g of selenium were determined in the sediments. Interferences by foreign ions were eliminated by the coprecipitation procedure. Selenium added was recovered by 95–101%.
    Notizen: Zusammenfassung Gehalte bis zu mehreren μg/g Selen wurden nach dem verbesserten Verfahren in den Sedimenten des Hafens von Nagoya bestimmt. Störungen durch Fremdionen wurden durch das Mitfällungsverfahren mit Tellur/Ascorbinsäure verhindert. Zugesetztes Selen wurde zu 95 bis 101% wiedergefunden.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00635683
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  • 10
    Digitale Medien
    Digitale Medien
    Determination of selenium(IV) and other forms of selenium dissolved in sea water by anion-exchange resin loaded with sulfonic acid derivative of bismuthiol-II and hydride generation atomic-absorption spectrometry (1989)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 333 (1989), S. 102-107 
    Details
    ISSN: 1618-2650
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary A sulfonic acid derivative of bismuthiol-II (bisIIS) was synthesized from 4-hydrazinobenzene sulfonic acid and carbon disulfide. Selenium(IV) was adsorbed selectively and quantitatively on the anion-exchange resin loaded with bis-IIS. Selenium adsorbed on the resin was eluted by the use of penicillamine and determined by hydride generation atomic absorption spectrometry (hydride generation/AAS). Selenium(VI) and other forms of selenium, which were not adsorbed onto the resin, were collected on the resin after digestion with nitric acid followed by reduction with hydrochloric acid. Separative preconcentration of selenium(IV), selenium(VI) and other forms of selenium in 0.5 mol/l sodium chloride could be carried out successfully by the proposed procedures. However, in the case of estuarial sea water containing a large quantity of organic substances, selenium(IV) could not be separated, because organic substances interfered with the reduction of selenium(VI) to selenium(IV) by the use of hydrochloric acid. Selenium(IV) and total amount of selenium(VI) and other forms of selenium dissolved in polluted sea water samples were determined by the proposed procedures.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00474017
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