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  • 1
    Electronic Resource
    Electronic Resource
    Movement and segregation of kinetochores experimentally detached from mammalian chromosomes (1988)
    [s.l.] : Nature Publishing Group
    Nature 336 (1988), S. 251-254 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] When Chinese hamster cells were arrested at the Gl/S boun-dary of the cell cycle by treatment with 2 mM hydroxyurea for 20 h and subsequently treated for 4-6 h with caffeine (5 mM), the cells entered mitosis without completing DNA synthesis as originally observed in BHK (baby hamster kidney) ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/336251a0
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  • 2
    Electronic Resource
    Electronic Resource
    Progression of a myelodysplastic syndrome to pre-B acute lymphoblastic leukemia: a case report and cell lineage study (1996)
    Springer
    Annals of hematology 73 (1996), S. 35-38 
    Details
    ISSN: 1432-0584
    Keywords: Key words Lymphoblastic leukemia ; Myelodysplastic syndrome ; Fluorescence in situ hybridization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The evolution of acute lymphoblastic leukemia from a myelodysplastic syndrome is a very uncommon event. We describe a 46-year-old man in whom refractory anemia with excess blasts (RAEB) evolved to a pre-B acute lymphocytic leukemia. Trisomy 8 was one of the cytogenetic abnormalities in the dysplastic clone and was detected in both peripheral blood and bone marrow smears of interphase cells by the fluorescence in situ hybridization (FISH) technique. Using a chromosome 8 centromeric specific DNA probe we identified the trisomy 8 to be present in lymphoblasts, erythroid precursors, myeloblasts, promyelocytes, myelocytes, metamyelocytes, granulocytes, and monocytes. Our case supports the hypothesis that in MDS the pluripotent precursor cell is affected, and we examine the potential role of FISH for the study and follow-up of some hematological diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050197
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  • 3
    Electronic Resource
    Electronic Resource
    Trisomic categories in pearl millet (Pennisetum americanum (L.) Leeke) (1988)
    Springer
    Theoretical and applied genetics 75 (1988), S. 340-343 
    Details
    ISSN: 1432-2242
    Keywords: Pearl millet ; Primary ; Secondary ; Tertiary trisomy ; Interchanges
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary In pearl millet [Pennisetum americanum (L.) Leeke], in the open pollinated and crossed progenies of autotriploids, desynaptics and translocation heterozygotes, two primary trisomics, one each of secondary and tertiary trisomics, two primary trisomics with interchanges, two interchange secondary trisomics, and three interchange tertiary trisomics were located. These categories were determined on the basis of chromosomal associations formed at meiosis. In one other trisomic, its category, whether tertiary or interchange trisomy, could not be determined. Some of these categories, like the secondary trisomy and interchange tertiary trisomy, are reported for the first time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00303974
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  • 4
    Electronic Resource
    Electronic Resource
    Calcium oxalate crystallization kinetics at different concentrations of human and artificial urine, with a constant calcium to oxalate ratio (1999)
    Springer
    Urological research 27 (1999), S. 231-237 
    Details
    ISSN: 1434-0879
    Keywords: Key words Calcium ; Oxalate ; Calcium oxalate crystallization ; MSMPR ; Urolithiasis ; Urine volume
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of in vitro dilution of artificial urine or human urine on the crystallization of calcium oxalate was examined in a mixed suspension, mixed product removal crystallization system. Direct growth inhibition by components of artificial urine was not significant and supersaturation was the dominant factor in determining crystal nucleation and growth rates. Dilution of human urine caused a decrease in crystal growth rate that was independent of the input calcium and oxalate concentrations, suggesting that dilution of growth inhibitors could be physiologically more important than any reduction in supersaturation. This loss of growth inhibition was counteracted by a reduction in nucleation promotion, with the net effect that the mass of crystals declined. Correlation of crystallization measurements with urinary concentration (osmotic pressure) confirmed these observations, with a negative relationship for growth rate and a positive relationship for nucleation rate and suspension density. Increasing the concentration of urine shifts the crystallization balance from low nucleation/high growth to high nucleation/low growth. Calcium oxalate crystalluria in healthy urine is therefore less likely at early stages of urine development in the nephron and the likelihood can be further reduced by increased fluid output. Our results suggest that lowering the heterogeneous nucleation activity by dilution is more than sufficient to override the loss of growth inhibition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002400050115
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  • 5
    Electronic Resource
    Electronic Resource
    A study of morphology, cytology and sterility in interspecific hybrids and amphidiploids of Nicotiana knightiana X N. umbratica (1985)
    Springer
    Theoretical and applied genetics 70 (1985), S. 330-332 
    Details
    ISSN: 1432-2242
    Keywords: Nicotiana knightiana ; N. umbratica ; Interspecific hybrids ; Cytology ; Female sterility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Interspecific hybrids and amphidiploids of Nicotiana knightiana Goodspeed (n= 12)x N. umbratica Burbidge (n = 23) resembled either parent in some characters and were intermediate in other characters. The F1 hybrids (2n = 35) showed mostly univalents during meiosis, while the amphidiploids (2n = 70) formed bivalents almost regularly. The former were completely sterile and the latter fully male fertile but predominantly female sterile. This female sterility was due to disintegration of the embryo sacs leading to collapsed ovules. The few fertile ovules, however, showed normal development of embryo sac and embryo. The occurrence of fertile and sterile ovules was believed to be due to segregation of the genes governing sterility.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00304921
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  • 6
    Electronic Resource
    Electronic Resource
    Distribution of phosphorylated spindle-associated proteins in the diatom Stephanopyxis turris (1989)
    New York, NY : Wiley-Blackwell
    Cell Motility and the Cytoskeleton 12 (1989), S. 33-41 
    Details
    ISSN: 0886-1544
    Keywords: phosphorylation ; MPM-2 ; mitotic spindle ; microtubule-associated protein ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Mitotic spindles isolated from the diatom Stephanopyxis turris become thiophosphorylated in the presence of ATPγS at specific locations within the mitotic apparatus, resulting in a stimulation of ATP-dependent spindle elongation in vitro. Here, using indirect immunofluorescence, we compare the staining pattern of an antibody against thiophosphorylated proteins to that of MPM-2, an antibody against mitosis-specific phosphoproteins, in isolated spindles. Both antibodies label spindle poles, kinetochores, and the midzone. Neither antibody exhibits reduced labeling in salt-extracted spindles, although prior salt extraction inhibits thiophosphorylation in ATPγS. Furthermore, both antibodies recognize a 205 kd band on immunoblots of spindle extracts. Microtubule-organizing centers and mitotic spindles label brightly with the MPM-2 antibody in intact cells. These results show that functional mitotic spindles isolated from S. turris are phosphorylated both in vivo and in vitro. We discuss the possible role of phosphorylated cytoskeletal proteins in the control of mitotic spindle function.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cm.970120105
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