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  • 1
    ISSN: 1420-9071
    Keywords: CQP 201-403 ; 8α-amino-ergolines ; ergot pharmacology ; D-2 agonist ; endocrine ; CNS ; cardiovascular actions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The profile of action in animals of CQP 201-403, a novel 8α-amino-ergoline, is in most aspects that of a very potent dopaminomimetic, both as a prolactin secretion inhibitor, and at the levels of the CNS and the cardiovascular system. Qualitatively CQP 201-403 differs slightly from bromocriptine and apomorphine in its effects on the CNS (no influence on serotonin metabolism in the rat cortex; induction of masculine mounting behavior in rats) and the cardiovascular system of the dog (reflex tachycardia in response to a blood-pressure fall). In man the new compound proved to be highly active in lowering prolactin serum levels and to be more potent than bromocriptine (Parlodel®).
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Chronic ingestion of bile-acid sequestrants has been shown to decrease the serum cholesterol concentration and coronary events in hypercholesterolaemic patients. To develop improved sequestrants, a rapid, convenient method for testing the bile-acid binding efficacy of sequestrants is needed. Serum bile-acid concentrations could be used to detect bile-acid binding by an administered sequestrant, since the serum bile-acid concentration is determined largely by the rate of intestinal absorption in healthy individuals. To test this, serum bile-acid concentrations were measured at frequent intervals over 24 h in five otherwise healthy hypercholesterolaemic subjects during the ingestion of three standard meals, with or without the addition of 5 g colestipol granules administered 30 min before each meal.Total serum bile-acid concentration was measured with a previously reported bioluminescent enzymic assay, that uses a 3α-hydroxysteroid dehydrogenase, an oxido-reductase, and a bacterial luciferase co-immobilized on to Sepharose beads. Bile acids in 1 ml of serum were isolated by solid-phase extraction chromatography with reversed-phase C18 cartridges.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 296 (1960), S. 388-402 
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Contributions to mineralogy and petrology 97 (1987), S. 31-42 
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract The Ivrea zone represents a tilted cross section through deep continental crust. Sm-Nd isotopic data for peridotites from Baldissero and Balmuccia and for a suite of gabbros from the mafic formation adjacent to the Balmuccia peridotite provide evidence for an event of partial melting 607±19 Ma ago in an extended mantle source with ɛ 607 Nd =+0.4±0.3. The peridotites are interpreted as the corresponding melt residue, the lower part of the mafic formation as the complementary melts which underwent further differentiation immediately after extraction. The Finero body represents a complex with layers of phlogopite peridotite, hornblende peridotite, and amphibole-rich gabbro. The isotopic signatures fall into two groups: (1) highly radiogenic Nd and low-radiogenic Sr characterize the phlogopite-free, amphibole-rich rocks, whereas (2) low-radiogenic Nd and highly radiogenic Sr is found in ultramafics affected by “phlogopite metasomatism”. Phlogopite metasomatism in the Ivrea zone is dated by a Rb-Sr whole rock isochron yielding 293±13 Ma. It was fed by K-rich fluids which were probably derived from metasediments. The high initial ɛ 293 Nd value of about +7.5 for phlogopite-free samples indicates a high time-integrated Sm/Nd ratio in the Finero protolith 293 Ma ago. Sm-Nd analyses of metapelites from the paragneiss series yield Proterozoic “crustal residence ages” of 1.2 to 1.8 Ga. Internal Sm-Nd isochrons for three garnetiferous rocks show that closure of garnet at temperatures around 600° C or even lower occurred about 250 Ma ago.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Contributions to mineralogy and petrology 98 (1988), S. 408-416 
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract The Ascutney Mountain complex of eastern Vermont, USA, is a composite epizonal pluton of genetically related gabbro to granite intrusives. Nd isotopic data are reported for mafic rocks, granites, and nearby country rock. The parental mafic magma producing the complex 122 m.y. ago had 87Sr/86Sr=0.7039, 143Nd/144Nd=0.512678 (ɛ Nd=+3.8) and δ 18O=6.1‰, indicating a mantle source with time-integrated lithophile element depletion. Uniform initial radiogenic isotope ratios for granites, which are undistinguishable from those for the most primitive gabbro, suggest that the granite magma evolved from the mafic magma without crustal contamination and that the increase in δ 18O, to about 7.8‰, is the result of fractional crystallization. Mafic rocks show a large range in initial 143Nd/144Nd ratio, from about 0.51267 to 0.51236 (ɛ Nd= +3.7 to −2.5), which is correlated with elevated 87Sr/86Sr ratios and δ 18O. These data substantiate the production of mafic lithologies by fractional crystallization of the parental magma accompanied by assimilation of up to about 50% crust. The local country rocks include gneiss and schist and assimilation involved representatives of both rock types. The isotopic and chemical relationships preclude derivation from a single batch of magma undergoing contamination and indicate that a large magma body at depth evolved largely by fractionation with batches of melt issued from this chamber being variably contaminated at higher levels or at the level of emplacement. The Precambrian gneisses of the Chester dome and overlying lower Paleozoic schists have essentially identical Nd isotope systematics which suggest a crustal formation age of about 1.6. b.y. The parental sediments for the schists were apparently derived from a protolith similar to the gneissic basement without appreciable Sm/Nd fractionation.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1573-6903
    Keywords: Bile acids ; human infant formula ; taurine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The concentrations of taurine in a number of brain regions and in other tissues of rhesus morkeys fed a taurine-free human infant formula for 3 months are substantially lower than in similar monkeys fed the same formula supplemented with taurine. Activities of enzymes involved in taurine biosynthesis were not different in the two groups except for liver cysteinesulfinic acid decarboxylase, which was greater in the monkeys fed formula alone. There was no difference in the biliary bile acid composition, but the proportion of bile acids conjugated with taurine was significantly greater in the monkeys fed formula supplemented with taurine. These results indicate that the effects of a taurine-deficient diet on infant primates are widespread.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 16 (1960), S. 414-414 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The psychotomimetic active principles of the ancient aztec drug «Ololiuqui» (Rivea corymbosa (L.) Hall. f.) have been found to be alkaloids of the ergot type. Three of the components could be crystallized and identified, i.e. ergine (isolysergic acid amide), isoergine (Lysergic acid amide) and chanoclavin. The same alkaloids were found in the seeds of the related convolvulaceous vineI pomoea tricolor Cav.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 17 (1961), S. 108-108 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Ergot alkaloids of the peptide type and their dihydro-derivatives can be converted reversibly in acid solution into isomeric compounds. They are characterised by the prefix ‘aci’, e.g. aci-ergotamine, aci-dihydro-ergotamine. The isomerisation takes place in the peptide part of the molecule.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 17 (1961), S. 206-207 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The total synthesis of the Ergot alkaloid Ergotamine is described.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 19 (1963), S. 397-398 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A description is given of the isolation from ergot ofd-Lysergyl-l-valine methyl ester, a new minor alkaloid.
    Type of Medium: Electronic Resource
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