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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 77 (1955), S. 820-821 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Chronic ingestion of bile-acid sequestrants has been shown to decrease the serum cholesterol concentration and coronary events in hypercholesterolaemic patients. To develop improved sequestrants, a rapid, convenient method for testing the bile-acid binding efficacy of sequestrants is needed. Serum bile-acid concentrations could be used to detect bile-acid binding by an administered sequestrant, since the serum bile-acid concentration is determined largely by the rate of intestinal absorption in healthy individuals. To test this, serum bile-acid concentrations were measured at frequent intervals over 24 h in five otherwise healthy hypercholesterolaemic subjects during the ingestion of three standard meals, with or without the addition of 5 g colestipol granules administered 30 min before each meal.Total serum bile-acid concentration was measured with a previously reported bioluminescent enzymic assay, that uses a 3α-hydroxysteroid dehydrogenase, an oxido-reductase, and a bacterial luciferase co-immobilized on to Sepharose beads. Bile acids in 1 ml of serum were isolated by solid-phase extraction chromatography with reversed-phase C18 cartridges.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 15 (1959), S. 101-102 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Psilocin, a by-product of Psilocybin which is the active principle of hallucinogenic mushrooms, has been identified as 4-hydroxy-dimethyltryptamine.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Contributions to mineralogy and petrology 98 (1988), S. 408-416 
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract The Ascutney Mountain complex of eastern Vermont, USA, is a composite epizonal pluton of genetically related gabbro to granite intrusives. Nd isotopic data are reported for mafic rocks, granites, and nearby country rock. The parental mafic magma producing the complex 122 m.y. ago had 87Sr/86Sr=0.7039, 143Nd/144Nd=0.512678 (ɛ Nd=+3.8) and δ 18O=6.1‰, indicating a mantle source with time-integrated lithophile element depletion. Uniform initial radiogenic isotope ratios for granites, which are undistinguishable from those for the most primitive gabbro, suggest that the granite magma evolved from the mafic magma without crustal contamination and that the increase in δ 18O, to about 7.8‰, is the result of fractional crystallization. Mafic rocks show a large range in initial 143Nd/144Nd ratio, from about 0.51267 to 0.51236 (ɛ Nd= +3.7 to −2.5), which is correlated with elevated 87Sr/86Sr ratios and δ 18O. These data substantiate the production of mafic lithologies by fractional crystallization of the parental magma accompanied by assimilation of up to about 50% crust. The local country rocks include gneiss and schist and assimilation involved representatives of both rock types. The isotopic and chemical relationships preclude derivation from a single batch of magma undergoing contamination and indicate that a large magma body at depth evolved largely by fractionation with batches of melt issued from this chamber being variably contaminated at higher levels or at the level of emplacement. The Precambrian gneisses of the Chester dome and overlying lower Paleozoic schists have essentially identical Nd isotope systematics which suggest a crustal formation age of about 1.6. b.y. The parental sediments for the schists were apparently derived from a protolith similar to the gneissic basement without appreciable Sm/Nd fractionation.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Contributions to mineralogy and petrology 97 (1987), S. 31-42 
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract The Ivrea zone represents a tilted cross section through deep continental crust. Sm-Nd isotopic data for peridotites from Baldissero and Balmuccia and for a suite of gabbros from the mafic formation adjacent to the Balmuccia peridotite provide evidence for an event of partial melting 607±19 Ma ago in an extended mantle source with ɛ 607 Nd =+0.4±0.3. The peridotites are interpreted as the corresponding melt residue, the lower part of the mafic formation as the complementary melts which underwent further differentiation immediately after extraction. The Finero body represents a complex with layers of phlogopite peridotite, hornblende peridotite, and amphibole-rich gabbro. The isotopic signatures fall into two groups: (1) highly radiogenic Nd and low-radiogenic Sr characterize the phlogopite-free, amphibole-rich rocks, whereas (2) low-radiogenic Nd and highly radiogenic Sr is found in ultramafics affected by “phlogopite metasomatism”. Phlogopite metasomatism in the Ivrea zone is dated by a Rb-Sr whole rock isochron yielding 293±13 Ma. It was fed by K-rich fluids which were probably derived from metasediments. The high initial ɛ 293 Nd value of about +7.5 for phlogopite-free samples indicates a high time-integrated Sm/Nd ratio in the Finero protolith 293 Ma ago. Sm-Nd analyses of metapelites from the paragneiss series yield Proterozoic “crustal residence ages” of 1.2 to 1.8 Ga. Internal Sm-Nd isochrons for three garnetiferous rocks show that closure of garnet at temperatures around 600° C or even lower occurred about 250 Ma ago.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Apparent crustal residence ages indicated by Nd model age data for metamorphic rocks, sediments and granitoids of the Hercynian Fold Belt of Europe vary from 1.3 Ga to 3.0 Ga, but are mainly in the range 1.4–1.7 Ga. 2 Ga basement inliers have been documented previously in northern Spain and islands off northwestern France but, in addition to these, old (∼2–3 Ga) model ages are found along the southern margin of the fold belt. These do not identify old inliers but are interpreted to represent Archeanearly Proterozoic crustal components recycled from a southern source. The Nd data, when considered together with the surface geology and recent single-grain zircon ion microprobe data, argue against a binary mixing of Archean components with new Palaeozoic crustal additions to generate the main 1.4–1.7 Ga model age population. Hercynian Europe comprise mainly recycled Proterozoic components although significant new Palaeozoic additions as well as Archean contributions are indicated. Nd and Sr isotopic data together with previous chemical and petrographic observations allow the recognition of a northern belt of continent margin I-type granitoids grading southwards to inner continent S-type plutons in the eastern half of the fold belt. This felsic plutonic association is used to infer a Hercynian plate configuration involving the attachment of the fold belt to a southern parent cratonic block that the model age data suggest may be of early Proterozoic-Archean age.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Solar physics 107 (1986), S. 123-133 
    ISSN: 1573-093X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Two remarkable intensity-time patterns in the 113 and 64 MHz single-frequency radio flux records during a type I noise storm and/or a type IV burst on 31 July, 1983 are studied. A comparison of the patterns at both frequencies reveals a high degree of resemblance and inherent common structure although the 64 MHz pattern was seen 40 min later than the 113 MHz pattern. An interpretation is given assuming a slowly uprising and thereby expanding clumpy plasma-magnetic field configuration which is (via accompanying coronal loops) two times illuminated by energetic electrons coming from the soft X-ray flare precursor source region of the H-alpha flares F1 and F2 (see Figure 1).
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Solar physics 108 (1987), S. 151-167 
    ISSN: 1573-093X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Using photospheric and Hα observations and total radio flux data we study a two-ribbon flare in AR NOAA 4263 which was a part of a flare event complex on July 31, 1983. We find some facts which illuminate the special way of flare triggering in the analysed event. Around a double spot the photospheric vector magnetic field is discussed with respect to the chromospheric activities. In one of the spots the feet of long stretched loops are pushed down under steepening loops rooted in the same spot. This causes energy build-up by twist and shear in the stretched loops. One foot of the two-ribbon flare (triggered in the stretched and underpushed loop system) roots in a part of the spot umbra and penumbra where the field runs in extremely flat ‘like a pressed spiral spring’. A strange radio event, starting before the flares, can be interpreted as a precursor activity of the flare event complex. The radio data support the view that the analyzed flare process and the given magnetic field structure, respectively, are not very effective in energetic particle generation and escape.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1420-9071
    Keywords: CQP 201-403 ; 8α-amino-ergolines ; ergot pharmacology ; D-2 agonist ; endocrine ; CNS ; cardiovascular actions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The profile of action in animals of CQP 201-403, a novel 8α-amino-ergoline, is in most aspects that of a very potent dopaminomimetic, both as a prolactin secretion inhibitor, and at the levels of the CNS and the cardiovascular system. Qualitatively CQP 201-403 differs slightly from bromocriptine and apomorphine in its effects on the CNS (no influence on serotonin metabolism in the rat cortex; induction of masculine mounting behavior in rats) and the cardiovascular system of the dog (reflex tachycardia in response to a blood-pressure fall). In man the new compound proved to be highly active in lowering prolactin serum levels and to be more potent than bromocriptine (Parlodel®).
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 14 (1958), S. 397-399 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The structure of Psilocybin, the psychotropic active principle of the Mexican mushroomPsilocybe mexicana Heim, has been elucidated. Psilocybin is the phosphoric acid ester of 4-hydroxy-dimethyltryptamine. This structure was confirmed by total synthesis.
    Type of Medium: Electronic Resource
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