ISSN:
1432-1076
Keywords:
Cystic fibrosis
;
Pulmonary artery hypertension
;
Right ventricular function
;
Krypton 81m angiocardiography
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract A combined haemodynamic and radionuclide approach was used to evaluate right ventricular performance in 16 adolescent and adult patients with cystic fibrosis (CF). There were nine patients with mild arterial hypoxaemia (PaO2〉80% of predicted) and normal resting pulmonary artery pressure and seven patients with severe arterial hypoxaemia (PaO2〈70% of predicted) and resting pulmonary arterial hypertension (PH). The right ventricular ejection fraction (RVEF) by equilibrium angiocardiography using krypton 81m as a tracer and stroke volume index (SVI) by thermodilution techniques were measured simultaneously and right ventricular end-diastolic and end-systolic volumes were derived. RVEF was normal in CF patients without PH (58.9±7.2%) but was reduced in those with PH (45.4±2.6%). There was a statistically significant inverse linear correlation between RVEF and afterload as assessed by mean pulmonary artery pressure $$(\overline {Pap} :r = - {\text{0}}{\text{.76)}}$$ and pulmonary vascular resistance (PVR: r=−0.78), indicating that RVEF ist afterload-dependent. Right ventricular function, however, as assessed by right ventricular end-systolic pressure-volume relations was even higher in CF patients with PH, indicating preserved or even increased right ventricular function in the face of an increased afterload stress.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00441398
Permalink