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Intermolecular complexes between three human CD1 molecules on normal thymus cells (1988)

Amiot, Martine ; Dastot, Helene ; Fabbi, Marina ; [et al.]

Springer

Immunogenetics 27 (1988), S. 187-195

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ISSN: 1432-1211

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract The first cluster of differentiation (CD1) defines at least three distinct human thymic cell-surface differentiation antigens-CD1a, CD1b, and CD1c. We looked for structural homology of the three CD1 heavy chains at their peptide level by two-dimensional peptide maps. We show here that the CD1a M r 49 000 heavy chain and the CD1b M r 45 000 heavy chain appear to be more homologous to each other than to the CD1c M r 43 000 heavy chain and that only one tyrosil peptide is common to the three heavy chains. Study of the CD1 heavy chains from several individuals reveals a very limited polymorphism of these molecules. We also demonstrate here that CD1a or CD1a-like molecules and other CD1 molecules can form intermolecular complexes on the surface of normal thymus cells. Molecules that are structurally very similar to CD1a molecules are associated noncovalently either with CD1c molecules or with CD1b molecules, and only CD 1a molecules can associate covalently with CD8 molecules. In contrast, we could not find these intermolecular complexes on the surface of leukemic T-cell lines in culture.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00346585

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Suppressor effects and cyclic AMP accumulation by the CD29 molecule of CD4 + lymphocytes (1989)

Groux, Hervé ; Huet, Stéphane ; Valentin, Hélèna ; [et al.]

[s.l.] : Nature Publishing Group

Nature 339 (1989), S. 152-154

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ISSN: 1476-4687

Source: Nature Archives 1869 - 2009

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Notes: [Auszug] We used eight anti-VLA monoclonal antibodies, all of which have a similar pattern of tissue distribution and react with thymocytes. Some are already well defined: K20 and 4B4-both of which were initially used to define CD29 (ref. 5)-and TS2/16 all recognize the common /3-subunit6, whereas HP2/1 ...