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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Rheumatology international 8 (1988), S. 47-53 
    ISSN: 1437-160X
    Keywords: Rabbit ; Tenosynovitis ; Antigen ; Tendon ; Rheumatoid arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Rabbits were first immunized and later challenged with the same antigen (bovine serum albumin, or ferritin) by injection into the tibialis anterior tendon. Inflammatory changes of the tenosynovium and epitenon included infiltration by neutrophils (early) and mononuclear cells (later) over a 6-week course of tenosynovitis. A pattern of antigen entrapment in the tendon together with immunoglobulin was shown by use of radiolabelled antigen and immunochemical staining. Half-life of antigen in the tissues averaged 5 days over the 6-week period. Changes in the epitenon included cellular necrosis, appearance of phagocytic cells, and disruption of the collagen matrix. Tissues of control animals (challenged without prior immunization) showed minimal changes and significantly less retention of antigen (P〉0.005). The model is relevant to the mechanism of tendon damage associated with antigen-driven chronic inflammation, as may be the case in rheumatoid arthritis.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Hoboken, NJ [u.a.] : Wiley-Blackwell
    Journal of Orthopaedic Research 4 (1986), S. 129-131 
    ISSN: 0736-0266
    Keywords: Life and Medical Sciences
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Hoboken, NJ [u.a.] : Wiley-Blackwell
    Journal of Orthopaedic Research 6 (1988), S. 863-870 
    ISSN: 0736-0266
    Keywords: Life and Medical Sciences
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Seventeen female and 24 male subjects had varus and valgus and apparent rotations measured using a standardized mechanical testing device that cyclically applied a 20-Nm moment in each direction. Five parameters-apparent varus rotation, apparent valgus rotation, apparent overall rotation, varus stiffness, and valgus stiffness showed intersubject variations approaching 40%. Right-left variations in the same subject averaged 12%, with no significant right-left differences overall. Female knees rotated 66% more than male knees and were 35% less stiff. The ratio of apparent valgus rotation to apparent varus rotation averaged 0.775, and the ratio of valgus stiffness to varus stiffness averaged 1.23 for all knees. Stiffness and rotation parameters were highly correlated for both genders in the valgus phase of testing. Results suggest that although magnitudes of measured parameters vary considerably from subject, common relationships between parameters from the same normal knee exist.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Hoboken, NJ [u.a.] : Wiley-Blackwell
    Journal of Orthopaedic Research 3 (1985), S. 484-491 
    ISSN: 0736-0266
    Keywords: Fibrocartilage ; Anatomy ; Digital joints ; Life and Medical Sciences
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Observations were made from the dissection of 156 digital joints (thumbs excluded). In all joints fibrocollagenous menisci projected into the articular cavity from a ring-like structure based on the joint capsule. These meniscal structures separated the articulating cartilage surfaces at the margins of the joint. Histological examination confirmed a fibrocartilaginous nature of the tissue which demonstrated positive staining for proteoglycans and collagen fibers. Although generally similar in form, these meniscal structures varied in extent when compared between joint groups. The greatest amount and articular contribution was noted in metacarpophalangeal joints with least being found distally.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
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