ISSN:
1435-604X
Keywords:
Zn(II)-phthalocyanine
;
photosensitizer
;
photodiagnosis atheroma
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
,
Physics
,
Technology
Notes:
Abstract Phthalocyanines are structural analogs of porphyrins and are characterized by a closely similar mechanism of transport in the bloodstream. We evaluated the accumulation of liposomebound Zn(II)-phthalocyanine (Zn-Pc) by atherosclerotic aortas in rabbits. The biodistribution of intravenously injected Zn-Pc (0.023 mg/kg body weight) in the serum and some tissues resembled that previously observed for other experimental animals. Moreover, significant amounts of Zn-Pc were recovered from the aorta of the atherosclerotic and not of the normal rabbits. The maximum accumulation (circa 0.04μg of Zn-Pc g−1 tissue) was observed at 3 h after injection. We conclude that Zn-Pc might act as a fluorescence marker for atheromas and it has a potential as a phototherapeutic agent in atherosclerosis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02032431
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