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  • 1985-1989  (2)
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Material
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Histological and immunocytological changes in psoriasis after 7 days of cyclosporin therapy (1987)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 117 (1987), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In a double-blind trial, 21 patients were randomly assigned to receive oral cyclosporin or a vehicle control. Patients were treated for 4 weeks. Skin biopsies were taken before treatment and after 3 and 7 days. Epidermal thickness was measured by optical micrometer, and mitoses per high power field (HPF) were counted in lesional epidermis. Superficial perivascular mononuclear cell infiltrates, neutrophilic exudates and intraepidermal lymphocytosis were evaluated semi-quantitatively. Using single- and double-marker immunofluorescence techniques, the ratio of monoclonal antibody-defined leukocyte subsets to total leukocytes was also quantitatively determined.In patients receiving cyclosporin, epidermal thickness decreased by 32% compared with patients receiving only vehicle (P= 0·002). The average number of mitoses per HPF in lesional epidermis decreased by 71% by the end of 3 days of therapy. At 7 days, perivascular mononuclear cells decreased and the stratum corneum generally normalized.HLA-DR (Ia)-positive intraepidermal leukocytes found in psoriatic lesions before treatment or present in vehicle-treated lesions disappeared from the epidermis after 7 days of oral cyclosporin. Intradermal monocytes, T cells and activated T cells in the dermis decreased after 7 days of cyclosporin treatment in parallel with light microscopic findings.These findings suggest that psoriasis may have an immunological basis mediated by activated T cells and/or other immune cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1987.tb12012.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Double-blind, placebo-controlled study to evaluate the efficacy of fish oil and low-dose UVB in the treatment of psoriasis (1989)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 120 (1989), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Since eicosanoids have been implicated in the pathogenesis of psoriasis, less potent eicosanoid mediators derived from fish oil might improve psoriasis. Using a double-blind, randomized, parallel design, 18 patients with stable, plaque psoriasis received capsules of either fish oil or identical-appearing placebo olive oil for 15 weeks, with concomitant sub-erythemal UVB in weeks 3 to 11. At the conclusion of phototherapy, and 4 weeks later, patients in the fish oil group had a greater decrease in the total body surface area of psoriasis and more improvement compared to patients in the olive oil group. The improvement in the fish oil group was statistically significantly greater for all parameters compared to the change in the olive oil group. The apparent safety and general health-promoting features of fish oil could provide an ideal adjunctive therapy for psoriasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1989.tb01378.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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