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  • 1
    Electronic Resource
    Electronic Resource
    Nucleic acid chemistry: Resolution of supercoiled, intact relaxed, and nicked double-stranded DNAs by formamide-sucrose gradients
    Amsterdam : Elsevier
    Analytical Biochemistry 163 (1987), S. 200-203 
    Details
    ISSN: 0003-2697
    Keywords: DNA ; DNA damage ; mitochondria ; superhelical
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0003-2697(87)90113-8
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Alefacept therapy produces remission for patients with chronic plaque psoriasis (2003)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 148 (2003), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Background Alefacept, human LFA-3/IgG1 fusion protein, is a novel biological agent currently being developed for the treatment of chronic plaque psoriasis. Alefacept selectively reduces the memory-effector T cells that have been implicated in the pathogenesis of the disease; as a result, alefacept is classified as a therapy that induces remission (so-called ‘remittive’ therapy). In a previously published randomized, placebo-controlled phase II study of intravenous alefacept in 229 patients with chronic plaque psoriasis, clinical improvement was observed during dosing as well as in the postdosing follow-up period. Objectives To assess the remission period following alefacept therapy. Methods The time before re-treatment was required was measured in patients who were ‘clear’ or ‘almost clear’ of disease according to a physician global assessment at the end of the follow-up phase. Results In these patients, responses were sustained for a median of 10 months, and for up to 18 months. No patient reported disease rebound after cessation of alefacept. Conclusions Alefacept is a biological agent for the treatment of chronic plaque psoriasis that provides disease-free intervals and time off drug therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2003.05239.x
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  • 3
    Electronic Resource
    Electronic Resource
    Multiple warty dyskeratomas of the scalp (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 22 (1997), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Two patients presented with the unusual condition of multiple warty dyskeratomas on the scalp. Biopsies of affected skin stained positive with human keratin monoclonal antibodies HKN-6 and -7, specific for cortex and inner root sheath of normal human hair, respectively. Multiple warty dyskeratomas are a rare occurrence and their actiopathogenesis remains elusive. Positive immunohistochemical staining of a lesion with antikeratin antibodies HKN-6 and -7, specific for human hair keratin, suggests a follicular origin for warty dyskeratoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1997.tb01059.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Efficacy of cyclosporin A in psoriasis: a summary of the United States’ experience (1990)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 122 (1990), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Since its discovery in 1972, cyclosporin A (CyA) has been widely used in the experimental treatment of multiple inflammatory diseases considered to be of immune-mediated aetiology. In dermatology, oral CyA is most effective in the treatment of psoriasis and has been used successfully for plaque-type, pustular and erythrodermic forms of the disease. While dosages ranging from 1 to 14 mg/kg/day have been used, a starting dose of 4 mg/kg/day gives a rapid response with few side-effects. Nephrotoxicity remains the greatest concern in long-term use of the drug. Although intralesional CyA has proven effective in psoriasis, topical preparations have not. It is hoped that future research will provide effective topical formulations of CyA which are efficacious without the risks inherent in systemic administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1990.tb02878.x
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  • 5
    Electronic Resource
    Electronic Resource
    Double-blind, placebo-controlled study to evaluate the efficacy of fish oil and low-dose UVB in the treatment of psoriasis (1989)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 120 (1989), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Since eicosanoids have been implicated in the pathogenesis of psoriasis, less potent eicosanoid mediators derived from fish oil might improve psoriasis. Using a double-blind, randomized, parallel design, 18 patients with stable, plaque psoriasis received capsules of either fish oil or identical-appearing placebo olive oil for 15 weeks, with concomitant sub-erythemal UVB in weeks 3 to 11. At the conclusion of phototherapy, and 4 weeks later, patients in the fish oil group had a greater decrease in the total body surface area of psoriasis and more improvement compared to patients in the olive oil group. The improvement in the fish oil group was statistically significantly greater for all parameters compared to the change in the olive oil group. The apparent safety and general health-promoting features of fish oil could provide an ideal adjunctive therapy for psoriasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1989.tb01378.x
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  • 6
    Electronic Resource
    Electronic Resource
    Histological and immunocytological changes in psoriasis after 7 days of cyclosporin therapy (1987)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 117 (1987), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In a double-blind trial, 21 patients were randomly assigned to receive oral cyclosporin or a vehicle control. Patients were treated for 4 weeks. Skin biopsies were taken before treatment and after 3 and 7 days. Epidermal thickness was measured by optical micrometer, and mitoses per high power field (HPF) were counted in lesional epidermis. Superficial perivascular mononuclear cell infiltrates, neutrophilic exudates and intraepidermal lymphocytosis were evaluated semi-quantitatively. Using single- and double-marker immunofluorescence techniques, the ratio of monoclonal antibody-defined leukocyte subsets to total leukocytes was also quantitatively determined.In patients receiving cyclosporin, epidermal thickness decreased by 32% compared with patients receiving only vehicle (P= 0·002). The average number of mitoses per HPF in lesional epidermis decreased by 71% by the end of 3 days of therapy. At 7 days, perivascular mononuclear cells decreased and the stratum corneum generally normalized.HLA-DR (Ia)-positive intraepidermal leukocytes found in psoriatic lesions before treatment or present in vehicle-treated lesions disappeared from the epidermis after 7 days of oral cyclosporin. Intradermal monocytes, T cells and activated T cells in the dermis decreased after 7 days of cyclosporin treatment in parallel with light microscopic findings.These findings suggest that psoriasis may have an immunological basis mediated by activated T cells and/or other immune cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1987.tb12012.x
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  • 7
    Electronic Resource
    Electronic Resource
    Ciclosporin in psoriasis clinical practice: an international consensus statement (2004)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 150 (2004), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The main recommendations for the use of ciclosporin in the management of psoriasis are: (i) intermittent short courses (average of 12 weeks duration) of ciclosporin are preferable; (ii) ciclosporin should be given in the dose range 2·5–5·0 mg kg−1 day−1 (doses greater than 5·0 mg kg−1 day−1 should only be given in exceptional circumstances); (iii) treatment regimens should be tailored to the needs of each patient; (iv) selection of patients should take into account psychosocial disability, as well as clinical extent of disease and failure of previous treatment; (v) each patient's renal function (as measured by serum creatinine) should be thoroughly assessed before and during treatment; (vi) each patient's blood pressure should be carefully monitored before and during treatment; (vii) adherence to treatment guidelines substantially reduces the risk of adverse events; (viii) long-term continuous ciclosporin therapy may be appropriate in a subgroup of patients; however, duration of treatment should be kept below 2 years whenever possible; and (ix) when long-term continuous ciclosporin therapy is necessary, annual evaluation of glomerular filtration rate may be useful to accurately monitor renal function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0366-077X.2004.05949.x
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