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  • 1
    ISSN: 1432-1440
    Keywords: Human corticotropin-releasing factor (hCRF) ; C-peptide ; Naloxone ; Opioid receptor blockade ; Type 2 diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Administration of synthetic human corticotropin-releasing factor (hCRF, 2 µg/kg body weight) during simultaneous application of the opioid antagonist naloxone (1.6 mg i.v. bolus, followed by an infusion at a rate of 1.2 mg/h) produced a significant increase in plasma C-peptide levels of six male Type 2 diabetic patients which even exceeded the postprandial values. This stimulatory effect of hCRF/naloxone on plasma C-peptide was less pronounced in six healthy men. hCRF alone did not provoke any reaction of plasma C-peptide in either group. The possibility of a paracrine, CRF-dependent mechanism in pancreatic islets which somehow involves inhibitory opioid receptors is preferentially discussed. Such a mechanism may underlie the stimulatory action of hCRF/naloxone on B cells and would explain the absent reaction of peripheral venous plasma C-peptide to hCRF alone as well as the amplifying effect of simultaneous opioid receptor blockade.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 65 (1987), S. 453-457 
    ISSN: 1432-1440
    Keywords: Human corticotropin-releasing factor (hCRF) ; ACTH ; Cortisol ; Naloxone ; Opioid receptor blockade
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Administration of synthetic human corticotropin-releasing factor (hCRF; 2 µg/kg body weight) to six normal male subjects produced a significant rise in plasma ACTH, followed by an increase in circulating cortisol. Simultaneous treatment with the opioid antagonist naloxone (1.6 mg i.v. bolus, followed by an infusion at a rate of 1.2 mg/h) significantly potentiated the hCRF-induced rise in ACTH and enhanced the cortisol response to hCRF. It is suggested that naloxone acts by antagonizing an inhibitory ultra-short-loop feedback effect of coreleased β-endorphin on pituitary corticotrophs, thereby amplifying the net effect of hCRF, i.e., the release of ACTH.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 53 (1988), S. 180-181 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A variety of superlattices is predicted to exhibit high-speed carrier-activated light modulation. The proposal is based on the large, tunable, and very narrow absorption peak for transitions between the two lowest conduction subbands. The theory, which is demonstrated to be predictive, also suggests correspondingly large variations of the refractive index.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1459
    Keywords: Botulism ; Ophthalmoplegia ; Single-fibre electromyography ; Jitter ; Blockings
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of complete bilateral internal ophthalmoplegia as the sole clinical sign of botulism is reported. Diagnosis was immediately confirmed by single-fibre electromyography (SFEMG), which revealed abnormally high blocking (14.3%), contrasting with moderately increased jitter (mean consecutive difference in the extensor digitorum communis muscle, 43.9 μs). After giving equine botulinum antitoxin and simultaneous forced emptying of the bowels, ocular symptoms completely disappeared within 2 days. Six days, 5 weeks and 6 months after the first SFEMG study, the jitter was still abnormal, even becoming more so with time. Blocking, however, was only rarely observed in the follow-up studies. It is concluded that SFEMG may serve as a useful and sensitive method for the rapid diagnosis of botulinum intoxication, even in cases where no clinical signs of general muscular weakness are apparent.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Research in experimental medicine 189 (1989), S. 129-140 
    ISSN: 1433-8580
    Keywords: Auscultation ; Abdomen ; Bowel sounds ; Intestinal motility ; Acustic analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In an attempt to find a non-invasive method yielding a comprehensive insight into a patient's intestinal activity, continuous multichannel registration and analysis of acustic phenomena as produced by the intestines were performed. Previous work, described by others, was further developed with respect to topographical interpretation of the data obtained, and to the possible introduction into general clinical use by installing different methods of artifact detection and reduction. To record and process bowel sounds, a device developed for this purpose (Phonoenteroanalyzer PEA-06, G-W Elektronik, Munich, FRG) was used. Five specially designed microphones were placed on the abdominal wall. After amplification and filtering, further processing of the signal was achieved by means of rectifying, peak detection, and logarithmic transformation techniques, yielding a topographically discernible pattern of intestinal activity. Noise and movement artifacts, although a basic problem of this technique, could be adequately managed, e.g., by using a control microphone as well as simultaneous registration of breathing. Ten normal subjects as well as eight patients with manifest or suspected gastrointestinal problems, had their bowel sounds registered either continuously overnight or during adequate stimulatory tests (gastrocolonic response, neostigmine test, rectal distension). Bowel sounds were registrated as short “clicks” or longer lasting, sometimes rhythmically appearing, complex acustic phenomena. Overnight registrations revealed periodical changes in general or local intestinal activity, which in turn showed remarkable interindividual variabilities. Stimulatory tests provoked an enhancement of intestinal activity, which could well be documented with this method. In conclusion, analysis of acustic phenomena provoked by the bowels should henceforth allow an objective, continuous, long-term, non-invasive, indirect, and at any time repeatable topographical registration of intestinal activity.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1433-8580
    Keywords: Atrial natriuretic peptide ; ANP ; Gastrointestinal tract ; Gut ; Biopsies ; Endoscopy ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The human gastrointestinal tract, important for body salt and water balance, was investigated by endoscopic biopsy for the presence of atrial natriuretic peptide (ANP). Using immunohistochemistry, ANP-immunoreactive cells were identified in the lamina epithelialis mucosae of stomach, duodenum, jejunum, colon, and rectum. The findings indicate that ANP plays a role in intestinal salt and water regulation in man. ANP measurements in tissue specimens reached by endoscopic biopsy may be of major interest for future investigations on (patho-)physiological and pharmacological aspects of ANP.
    Type of Medium: Electronic Resource
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