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  • 1
    Electronic Resource
    Electronic Resource
    Modification of GABA turnover in the striatum and hippocampus of the rat after zopiclone (1987)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 335 (1987), S. 547-550 
    Details
    ISSN: 1432-1912
    Keywords: Zopiclone ; GABA turnover ; Striatum ; Hippocampus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of zopiclone, a non-benzodiazepine compound that interacts with benzodiazepine receptors, on GABA turnover rate and GABA content in the rat striatum and hippocampus have been studied. Intraperitoneal administration of zopiclone reduced the GABA turnover rates in both the striatum and hippocampus, as estimated from the rate of GABA accumulation after inhibition of GABA transaminase by aminooxyacetic acid (AOAA). The effect of zopiclone on AOAA-induced accumulation of GABA in the hippocampus and striatum was blocked by the intraperitoneal injection of the benzodiazepine receptor antagonist Ro 15-3505. Furthermore, zopiclone slightly but significantly decreased GABA content in the hippocampus, the decrease being blocked by coadministration of the benzodiazepine receptor antagonist Ro 15-1788. Our results confirm that the GABAergic system plays a role in the mechanism of action of zopiclone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00169122
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  • 2
    Electronic Resource
    Electronic Resource
    Zopiclone potentiates the antinociceptive effect of morphine in rats (1987)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 336 (1987), S. 526-529 
    Details
    ISSN: 1432-1912
    Keywords: Zopiclone ; Morphine ; Antinociception ; Benzodiazepines ; Benzodiazepine antagonists
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The antinociceptive effect of morphine, as determined by the tail-flick test, was dose-dependently increased by the intraperitoneal injection of zopiclone. The benzodiazepine antagonists Ro 15-1788 (flumazepil) and Ro 15-3505, when intraperitoneally injected, significantly antagonized the effect of intraperitoneal injection of zopiclone on morphine antinociception. Intrathecal injection of zopiclone potentiated morphine antinociception, while the intracerebroventricular injection of zopiclone failed to enhance morphine antinociception and the intracerebroventricular injection of flumazepil to antagonize the intraperitoneal-zopiclone-induced increase in morphine antinociception. These results suggest that benzodiazepine sites are specifically involved in the potentiating effect of zopiclone on morphine antinociception. The anatomical locations of the receptors involved seem to be at the spinal level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00169309
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Reversal of the effect of centrally-administered diazepam on morphine antinociception by specific (Ro 15-1788 and Ro 15-3505) and non-specific (bicuculline and caffeine) benzodiazepine antagonists (1986)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 333 (1986), S. 43-46 
    Details
    ISSN: 1432-1912
    Keywords: Analgesia ; Morphine ; Diazepam ; Benzodiazepine antagonists
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Diazepam, injected into the lateral ventricles reduced the antinociceptive effect of morphine in rats, as measured by the tail-flick method. Specific antagonists of diazepam (Ro 15-1788 and Ro 15-3505) had no effect themselves but prevented inhibition by diazepam of morphine antinociception. Furthermore, the action of diazepam was partially reversed by intracerebroventricular injection of bicuculline or caffeine. These findings support the view that the depressant effect of diazepam on morphine antinociception is specific and GABAergic in nature and that some actions of diazepam are also mediated via the purinergic system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00569658
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    Paper (German National Licenses)
    Fulltext
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