ZIB

Hits per page

hits 1 - 2 | 2 hits

Sorting

Electronic Resource

Pharmacokinetics of theophylline and enprofylline in patients requiring a high or low dose of theophylline (1985)

Laursen, L. C. ; Johannesson, N. ; Weeke, B.

Springer

European journal of clinical pharmacology 29 (1985), S. 115-117

add to mindlist on the mindlist

Details

ISSN: 1432-1041

Keywords: enprofylline ; theophylline ; pharmacokinetics ; patients ; theophylline requirement

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary In patients requiring a high or low dose of theophylline the pharmacokinetics of theophylline and enprofylline were studied. The low-dose group took an average daily dose of 8.91 mg/kg body wt. and the high-dose group 24.75 mg/kg body wt. The average half-life of theophylline in the former was 7.11 h and in the latter 4.72 h. The average clearances (CL) of theophylline were 2.83 and 4.58 l/h, respectively. The daily oral intake of theophylline was negatively correlated with the theophylline t1/2 (r=−0.63). While the t1/2 of enprofylline was similar in the two groups, CL and volume of distribution (Vc) were slightly (about 30%) but significantly higher in patients requiring a high dose of theophylline. CL of enprofylline did not correlate with CL of theophylline, nor was the Vc of the two drugs correlated. Interindividual variability in t1/2 and CL was considerably lower for enprofylline than for theophylline.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00547379

Permalink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

Electronic Resource

Effects of Enprofylline and Theophylline on Exercise-Induced Asthma (1985)

Laursen, L. C. ; Johannesson, N. ; Weeke, B.

Oxford, UK : Blackwell Publishing Ltd

Allergy 40 (1985), S. 0

add to mindlist on the mindlist

Details

ISSN: 1398-9995

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Eight asthmatic out-patients with a history of exercise-induced asthma (EIA) were randomly treated with intravenously administered enprofylline 1.5 mg/kg b.wt., theophylline 5 mg/kg b.wt., and placebo immediately prior to a 6-min exercise provocation in this double-blind crossover comparison. A reduction in peak flow of more than 20% was seen in all patients after placebo pre-treatment. Mean plasma concentrations at the start of the exercise test were 3.3 mg/1 and 13.2 mg/1 after 20 min infusion of enprofylline and theophylline, respectively. The corresponding figures 25 min later were 2.3 and 11.7, respectively. Maximal fall in peak expiratory flow (PEF) after exercise in percent of pre-exercise PEF was 49%± 6% (mean ± SEM), 39%± 6% and 24%± 5% after infusion of placebo, enprofylline, and theophylline, respectively. Theophylline produced a statistically significant better protection against EIA compared to enprofylline and placebo. Enprofylline produced a slight protection from EIA not statistically significantly different from placebo.