ISSN:
1420-908X
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Neural recordings were made from sensory fibres in a nerve supplying the ankle joint in normal rats and in rats with a novel monoarticular arthritis. The responses of mechanically and chemically sensitive units to intra-arterial injections of 5-HT were measured. In most cases the mechanosensitivity of sensory receptors in the ankle joint was not altered by 5-HT. However, 5-HT produced an increase in afferent activity in units which were identified as C-fibres on the basis of action potential amplitude and duration. The receptive fields of these chemosensitive units were not located. The responses of these units to 5-HT were dose dependent and were abolished by the 5-HT2-antogonist, ketanserin, but not by the 5-HT3-receptor antagonist, MDL 72222. The responses of chemosensitive units to injections of 5-HT were similar in normal and arthritic rats although the response was slightly prolonged in arthritic animals.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01965015
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