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  • 1985-1989  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Insulin Wakayama: familial mutant insulin syndrome in Japan (1987)
    Springer
    Diabetologia 30 (1987), S. 87-92 
    Details
    ISSN: 1432-0428
    Keywords: Insulin ; mutant ; familial ; gene ; high performance liquid chromatography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We describe a family from Japan displaying the mutant insulin syndrome with hyperinsulinaemia and an increased insulin: C-peptide molar ratio. Serum insulin isolated from several family members showed reduced in vitro biological activity, and analysis by high performance liquid chromatography revealed a peak co-eluting with human insulin and a second species of increased hydrophobicity co-migrating with the previously reported Insulin Wakayama. The insulin genes from the propositus were cloned and sequenced, revealing one normal allele; the second allele, encoding a leucine for valine amino acid substitution at position 3 of the insulin A chain, was similar to that previously described for Insulin Wakayama. Synthesized [LeuA3] insulin showed 0.14% of receptor binding activity on rat adipocytes and a 10-fold prolonged half-life in a somatostatin-infused dog compared with human insulin. The finding of the same mutant gene in two unrelated Japanese families suggests that Insulin Wakayama may be discovered in additional Japanese families with hyperinsulinaemia and/or diabetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00274577
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Antagonism of the in vivo and in vitro effects of leukotriene D4 by SC-39070 in guinea pigs (1987)
    Springer
    Inflammation research 20 (1987), S. 124-132 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Leukotriene D4 (LTD4) causes contractions of guinea pig isolated ilea, evokes pulmonary bronchoconstriction and induces lesions of the dermal vasculature. In the present study, we assessed the antagonism of these actions by SC-39070 compared to FPL-55712, a known LTD4 receptor antagonist. In guinea pig isolated ileum preparations, SC-39070 displayed selective antagonism of LTD4 with a pA2=8.20±0.06 (S.E.) and a Schild plot slope of −1.20. Administered intravenously to artificially-respired guinea pigs one minute prior to the agonist, SC-39070 antagonized (p〈0.05) the bronchoconstrictive effect of LTD4 in a dose-dependent manner (0.5–10 mg/kg). At a dose of 2.0 mg/kg, i.v. this activity was retained through a 60 minute pretreatment interval. Similarly, after oral administration of SC-39070, there was a dose-dependent antagonism of the bronchoconstrictive activity of LTD4 (MED50=3.8 mg/kg). Antagonism of LTD4-induced bronchoconstriction was evidenced after oral administration of SC-39070 within one hour of treatment and efficacy was retained as long as 20 hours after treatment at a dose of 10 mg/kg. Finally, intravenously administered SC-39070 blocked LTD4-induced dermal permeability in guinea pigs with a minimum effective dose of 1.0 mg/kg. In each assay, the LTD4 antagonism evidence after treatment with SC-39070 appeared to be equal to or greater than that observed after treatment with FPL-55712.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01965634
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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