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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 89 (1985), S. 1932-1937 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 48 (1987), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The activity of adenosine deaminase (ADA) was determined in whole brain of rats at the embryonic age of 15 days through to adulthood and in nine brain regions in rats 1 day old through to adulthood. In 1-day-old rats, the highest activity was seen in olfactory bulbs (550 ± 15 nmol/mg protein/30 min) and this was 4.5-fold higher than that in the pons, which was the lowest. In adult animals, olfactory bulb still contained the greatest activity, which was about eightfold higher than hippocampus, which had the lowest. Except for hypothalamus, where ADA activity increased nearly twofold in rats between the ages of 1 and 50 days, significant decreases of as much as fivefold were found in whole brain, superior colliculus, cortex, hippocampus, cerebellum, olfactory bulbs, and olfactory nucleus. In contrast, ADA activity in pons and subcortex remained relatively constant throughout the developmental period. The Km values for ADA in whole brain at 18 days gestation (48 ± 5 μM) were not significantly different from that observed in adult rats (38 ± 7 μM), whereas the Vmax values decreased significantly from 339 ± 9 to 108 ± 8 nmol/mg protein/30 min. Taken together, the developmental patterns observed in the various brain regions appear not to correspond to any one particular process such as periods of rapid cell proliferation, cell death, synaptogenesis, or myelination. Nor do they correspond to known developmental profiles of transmitters, their receptors, or their metabolic enzymes. The complex changes in ADA activity during ontogenesis suggest an important role of ADA at very early stages of development as well as in specific regions of the adult rat brain.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 27 (1988), S. 0 
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: At the onset or in the course of IgA nephropathy (IgA NP), upper respiratory tract infections and tonsillitis are often followed by periods of gross haematuria. In a search for possible abnormalities in the tonsillar IgA- and IgG-cell system, the palatine tonsils from seven patients with IgA NP and eight controls, all 15 suffering from chronic recurrent tonsillitis, were subjected to an immunohistochemical study. Compared with the controls, tonsils of NP patients contained a significantly (P〈0.001) increased proportion of IgA-producing cells (49.6% versus 35.7%). There was also an increase (P〈0.001) in the ratio of IgA polymer-(J-chain-positive) to monomer-producing cells in NP tonsils compared with controls (35.0% versus 18.8%). Although the tonsillar IgA cells were generally producing mainly IgA1, this subclass was even more predominant in NP tonsils (P〈0.03). These results are compatible with the hypothesis that in some patients with IgA NP, the polymeric IgA1 deposited in the mesangium may be of tonsillar origin.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 496 (1987), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 496 (1987), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Naturwissenschaften 75 (1988), S. 569-570 
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-198X
    Keywords: IgA nephropathy ; Henoch-Schönlein purpura ; Plasma ; PGI2-like activity ; Lipoproteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Plasma factors influencing vascular PGI2-like activity (PSA) were studied in 45 patients with IgA nephropathy, 18 with Henoch-Schönlein purpura, including 8 children with nephrotic syndrome, and 41 controls. The results were compared with the levels of plasma high-density lipoprotein (HDL), low-density lipoprotein (LDL) and fatty acid components of plasma phospholipids. The plasma of 38 of 45 patients with IgA nephropathy and 14 with Henoch-Schönlein purpura showed a diminished ability or no ability to support PSA. Twenty-three patients with IgA nephropathy and 10 with Henoch-Schönlein purpura exhibited an inhibitory activity against PGI2 production. The plasma HDL level was lower, while the LDL level and the LDL/HDL ratio were significantly higher in IgA nephropathy and Henoch-Schönlein purpura cases than in the controls. A high LDL/HDL ratio was associated with a low plasma PSA. The levels of arachidonic acid and its precursor were not lower in the plasma of patients than in the controls. The decreased PGI2 synthesis may play an important role in the pathogenesis of IgA nephropathy and Henoch-Schönlein purpura, but it can not be explained by reduced PG precursors. LDL may have an inhibitory, and HDL a protective effect on PGI2 synthesis.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Journal of thermal analysis and calorimetry 32 (1987), S. 1683-1691 
    ISSN: 1572-8943
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Es wurde experimentell nachgewiesen, daß die auf der Basis der Ergebnisse von isothermen thermogravimetrischen Untersuchungen gewonnen Isothermen zur Charakterisierung von industriell angewandten Silicongummis geeignet sind. Die experimentellen Ergebnisse ermöglichen einerseits die Berechnung einer für den thermischen Zersetzungsprozeß charakteristischen resultierenden Reaktionsgeschwindigkeitskonstanten und andererseits die Berechnung von Halbwertszeiten hinsichtlich der Gebrauchsdauer. Der Vergleich der Isothermen mit den errechneten charakteristischen Werten veranschaulicht den Einfluß der Parameter bei der Herstellung von Silicongummis und den Einfluß der Anwendungsbedingungen auf die thermische Stabilität.
    Abstract: Резюме Экспериментально до казано, что изотермы, полученные на основе результатов термогравиметричес кого анализа, пригодн ы для характеристики сили коновых каучухов, используемых в промы шленности. Экспериме нтальные результаты представ или возможность вычисления кажущихс я констант скорости п олных реакций, характерист ик процесса термического разлож ения и значений их пол ураспада в зависимости от срока их службы. Сопоставление изоте рм и вычисленных хара ктеристик показали, что термоус тойчивость силиконовых каучуко в затрагивается усло виями их получения и использо вания.
    Notes: Abstract It was proved experimentally that isotherms obtained from the results of isothermal thermogravimetric analysis are suitable for the characterization of silicone rubbers used in industry. The experimental results provide a possibility for the calculation of overall (apparent) reaction rate constants, characteristic of the thermal decomposition process, and for the calculation of half-life values in conjunction with the service life. Comparisons of the isotherms and of the characteristic calculated values demonstrated the effects of the parameters of silicone rubber preparation and of the conditions of application on the thermal stability.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Journal of thermal analysis and calorimetry 32 (1987), S. 1421-1433 
    ISSN: 1572-8943
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Die isotherme Thermogravimetrie liefert nützliche Informationen über die thermische Stabilität von Silkonkautschuk und Silikongummi. Der thermische Abbau verläuft nach einer Reaktion erster Ordnung. Messungen und Berechnungen haben bestätigt, daß in Vielkomponentensystemen die resultierende isotherme Zersetzungskurve sich additiv aus den Zersetzungskurven der Komponenten zusammensetzt, d. h., daß die thermische Zersetzung der Komponenten unabhängig voneinander verläuft.
    Abstract: Резюме Исследования показа ли, что изотермическа я термогравиметрия да ет полезную информацию о термиче ской устойчивости си ликонового каучука и силиконово й резины. Установлен первый по рядок реакций их терм ического разложения. Проведен ные измерения и вычисления подтверд или, что в многокомпон ентных системах результиру ющая кривая распада, получаемая в изотерм ических условиях, доп олнительно состоит из кривых раз ложения отдельных компонент, т. е. термическое разло жение компонентов протека ет независимо друг от друга.
    Notes: Abstract The investigations proved that isothermal thermogravimetry yields useful information on the thermal stability of silicone caoutchouc and silicone rubber. It was established that the thermal degradation is a first-order reaction. Measurements and calculations verified that in multicomponent systems the resultant degradation curve obtained by isothermal measurements is formed additively from the degradation curves of the components, i.e. the thermal decompositions of the components proceed independently of one another.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1612-1112
    Keywords: Displacement chromatography ; Displacement TLC ; Overloaded elution chromatography ; Spacer displacement thin-layer chromatography ; Spot profile
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Migration of spots in displacement development was investigated using a planar stationary phase. The effects of the presence or absence of the additive substances in the carrier were demonstrated when these compounds also played a role in the competition for the binding sites of the stationary phase; however, they were not members of the displacement train. In the case of displacement chromatography, compounds A+B are well separated but located very closely to each other. Using a spacer (C) in the sample, the peaks or spots of A and B are aparted by C and their virtual separation is increased. When compounds A+B were displaced by each other as well as by the displacer, the presence of the additive compound C in the carrier (carrier-spacer) can transfer an otherwise displaced component (A) into the so-called overloaded elution region of the chromatogram. At the same time the additive compound C does not unconditionally reduce the performance of displacement chromatography.
    Type of Medium: Electronic Resource
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