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  • 1
    Electronic Resource
    Electronic Resource
    Immunogenetic heterogeneity in Type 1 (insulin-dependent) diabetes among Japanese — HLA antigens and organ-specific autoantibodies (1989)
    Springer
    Diabetologia 32 (1989), S. 34-39 
    Details
    ISSN: 1432-0428
    Keywords: Type 1 (insulin-dependent) diabetes ; HLA ; auto-antibodies ; islet cell antibody
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary HLA phenotypes and haplotypes in relation to organ-specific autoantibody responses were studied in 82 Japanese patients with Type 1 (insulin-dependent) diabetes. HLA-DRw9 antigen and HLA phenotype of DRw9/X (X: not DR4) were increased in patients with organ-specific autoantibodies other than islet cell antibody (CP〈0.02, RR=4.02 and p〈0.05, RR=2.30, respectively); whereas HLA-DR4 antigen and HLA phenotype of DR4/X (X: not DRw9) were increased in those without the autoantibodies (CP〈0.001, RR=3.95 and p〈0.01, RR=2.46, respectively). HLA haplotype of Bw61-DRw9 was increased in patients with the autoantibodies (p〈0.005, RR=4.94), and HLA haplotype of Bw54-DR4 was increased in those without the autoantibodies (p〈0.001, RR=5.52). The relative risk of HLA-DR4/DRw9 was the highest among all HLA-DR phenotypes or genotypes in patients either with or without the autoantibodies. No association was, however, found between the incidence of islet cell antibody and HLA-DR phenotypes. These findings suggest that Type 1 diabetes among Japanese is immunogenetically heterogeneous as is Type 1 diabetes among Caucasians; and the differences in HLA-association of Type 1 diabetes among ethnic groups might give a clue to understanding of a role of HLA-antigens in the development of Type 1 diabetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265401
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  • 2
    Electronic Resource
    Electronic Resource
    Lifespan and oviposition of the parasitic copepod Pseudomyicola spinosus under rearing conditions (1985)
    Springer
    Marine biology 87 (1985), S. 55-60 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The facultative parasitic copepod Pseudomyicola spinosus (Raffaele & Monticelli) was cultured and mated under laboratory conditions. Twenty virgin females were cultured in isolation and mated. They were cultured individually after mating, and examined for lifespan, number of ovipositions, number of eggs, and other features. The longest lifespan of a female P. spinosus was 2.3 years (849 d). This female laid eggs 106 times after a single mating, and all of the eggs developed. The lifespan and number of ovipositions varied with the individual, but the interval between ovipositions showed less variation (7.0±2.3 d). The number of eggs laid at one oviposition decreased with the increase in the age of the female. The number of eggs at each oviposition was smaller in laboratory females than in wild females, but the oviposition rhythm and the interval between ovipositions seemed to be the same. The sperms seem to survive for quite a while in the seminal receptacle of a female. A male can copulate a multiple of times. The lifespan of P. spinosus in the natural environment should be less than a year, considering the lifespan of the host mussels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00397005
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  • 3
    Electronic Resource
    Electronic Resource
    Comparison of trimethadione and antipyrine as indicators of oxidative drug metabolizing capacity in man (1989)
    Springer
    European journal of clinical pharmacology 36 (1989), S. 629-632 
    Details
    ISSN: 1432-1041
    Keywords: trimethadione ; antipyrine ; metabolite formation ; drug interaction ; cytochrome P-450 ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Ten healthy male volunteers were given trimethadione (TMO) 4 mg/kg and antipyrine (AP) 500 mg alone or concomitantly to determine whether the metabolism of the drugs was mediated by the same or closely related forms of cytochrome P-450. Whether administered alone or together the clearance (CL) and half-life (t1/2) of TMO and AP were the same, and there was a good correlation between the CL and t1/2 of TMO and AP (aloner=0.755 and 0.623, respectively; coadministeredr=0.771 and 0.503, respectively). Excretion of AP and its main metabolite and the clearance for production of AP metabolites after AP was administered alone were not significantly different when TMO and AP were taken together. When the two drugs were administered alone or coadministered, the correlation between the CL of TMO and the excretion of 3-hydroxymethyl-3-norantipyrine (NORA) was close (aloner=0.734, coadministeredr=0.749). The correlation between the CL of TMO and CLm of NORA when TMO and AP were given alone or concomitantly was 0.762 and 0.772, respectively. The findings suggest that TMO metabolism and the formation of NORA in healthy subjects are mediated by a closely related form(s) of the cytochrome P-450 system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637749
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  • 4
    Electronic Resource
    Electronic Resource
    Free radicals formed by reaction of germane with hydrogen atoms in xenon matrix at very low temperatures (1987)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 86 (1987), S. 4949-4951 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The radicals formed by the reaction of GeH4 with H in the Xe matrix were investigated by electron spin resonance (ESR) spectroscopy at very low temperatures. The radicals observed were identified as GeH3 and GeH5. The newly observed radical GeH5 is considered as the intermediate of the reaction H+GeH4→H2+GeH3. The ESR parameters of these radicals were determined by numerical deconvolution of the observed spectra.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.452665
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  • 5
    Electronic Resource
    Electronic Resource
    Electronic spin resonance spectra of SiH3 radicals trapped in the low temperature matrix of nonmagnetic isotopes of xenon (1989)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 90 (1989), S. 2992-2994 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Xenon enriched with nonmagnetic isotopes, in which the content of magnetic isotopes is less than 0.4%, has been used as the low temperature matrix for the observation of electronic spin resonance (ESR) spectra of SiH3 radicals and H atoms. The SiH3 radicals were generated by the reaction of SiH4 with H atoms produced by the photolysis of HI. Well resolved proton hyperfine structures, which were smeared out into a broad singlet spectrum when natural xenon was used as the matrix, were observed. The ESR parameters were determined by numerical deconvolution and compared with those obtained for the radicals trapped in other matrices. Simple doublet spectrum of H atoms without superhyperfine structures was also observed after the photolysis of HI at 4.2 K.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.455900
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  • 6
    Electronic Resource
    Electronic Resource
    Two cases of clear cell acanthoma: an immunohistochemical study (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 15 (1988), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Two cases of clear cell acanthoma are reported. The expression of carcinoembryonic antigen (CEA), involucrin and keratin proteins in the tumors was investigated immunohistochemically. In 1981, Penneys et al. reported that this tumor was not of sweat gland origin because of the absence of CEA. This study confirmed this, furthor, the pattern of positive reaction of involucrin also indicated that this tumor is not of swcat duct origin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1988.tb00511.x
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  • 7
    Electronic Resource
    Electronic Resource
    Magneto-optics of a quasi-zero-dimensional electron gas (1989)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 55 (1989), S. 168-170 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have investigated theoretically and experimentally the energy levels and allowed optical transitions with energies ΔE of a quasi-zero-dimensional (Q0D) electron gas in a magnetic field B. Using a two-dimensional harmonic confining potential with oscillator frequency ω0, the theory predicts two values for ΔE. The resonance position in the magnetotransmission spectra from the Q0D system realized on a grid-gate GaAs/AlGaAs heterostructure, depends strongly on the 2D confining potential induced by the gate voltage Vg and, when Vg=−0.5 and −1.5 V, agrees with ΔE calculated with (h-dash-bar)ω0=1.5 and 2.8 meV, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.102132
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  • 8
    Electronic Resource
    Electronic Resource
    Observations on the Taiwanese Strain of Leucocytozoon caulleryi (Haemosporina) in Chickens (1986)
    Oxford, UK : Blackwell Publishing Ltd
    The @journal of eukaryotic microbiology 33 (1986), S. 0 
    Details
    ISSN: 1550-7408
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: . The Taiwanese strain of Leucocytozoon caulleryi was isolated from an infected chicken in Taipei, Taiwan, and established in chickens and biting midges Culicoides arakawae from Japan. Sporogony of the strain in C. arakawae was completed on day 3 after the infective blood meals at 25°C. Sporozoites isolated from the salivary glands of C. arakawae on days 3 or 4 after feeding caused infection in all the chickens inoculated. The strain showed high pathogenicity for chickens. Mortality of chickens rose with an increase in the number of sporozoites inoculated. The prepatent period for chickens inoculated with sporozoites was 14 days. Parasites appeared in the peripheral blood of chickens on day 15 and disappeared on day 26 after sporozoite inoculation. Soluble antigens were found in the sera of chickens infected with the strain between 10 and 17 days after inoculation, and homologous antibodies appeared after 17 days. Antigens prepared from sera, schizonts, merozoites, and gametocytes of the Taiwanese strain reacted with the sera of chickens infected witt the same strain or the strain isolated in Japan. The chickens that recovered from a primary infection with the Taiwanese strain demonstrated complete resistance to reinfection with the same strain or the strain isolated in Japan.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1550-7408.1986.tb05597.x
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  • 9
    Electronic Resource
    Electronic Resource
    Intercalation of hexagonal boron nitride with potassium (1989)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 66 (1989), S. 2554-2558 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have performed photoluminescence, photoexcitation, and transmission electron microscopy measurements on boron nitride films grown by chemical vapor deposition and later reacted with potassium. After reaction, the potassium atoms were found to intercalate the BN host and to form a (2×2)R0° in-plane structure which is commensurate with the pristine BN lattice. Optical transitions with ∼2.7 eV onsets were found to occur within the ∼5-eV BN band gap and have been interpreted as Γ-point transitions between the K(4s) band and the BN(2p) bands. The absence of an appreciable shift in the E2g2 phonon frequency of the pristine and reacted films suggests that the charge transfer between the K and BN bands is very small.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.344219
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  • 10
    Electronic Resource
    Electronic Resource
    Coherent and thermal coherent state (1989)
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 30 (1989), S. 2883-2890 
    Details
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Notes: The characterization of coherent states as the quantum states that split into two uncorrelated beams is considered. The characterization leads to the study of coherent states at finite temperature—thermal coherent states (TCS's). These TCS's are defined within the formalism of thermo field dynamics (TFD). TFD allows a generalization of the uncertainty relation that accounts for both thermal and quantum fluctuations. The TCS is shown to be a minimal state for the generalized uncertainty relation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.528470
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