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  • 1
    Electronic Resource
    Electronic Resource
    (10) The prevalence of pustulotic arthro-osteitis in patients with palmoplantar pustulosis (1989)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 121 (1989), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1989.tb05961.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Interleukin 1 Activity Produced by Human Rheumatoid and Normal Dendritic Cells (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 23 (1986), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Dendritic cells (DC) from the synovial inflammatory tissue and peripheral blood of patients with rheumatoid arthritis and from the peripheral blood of normal blood donors were compared with the autologous monocytes for their capacity to produce and release interleukin I (IL-1). Synovial DC often spontaneously released higher amounts of IL-1 activity than unstimulated and lipopolysaccharide-stimulated peripheral blood DC and monocytes. The IL-1 production by both DC and monocytes increased alter stimulation with bacterial lipopolysaccharide- In contrast with synovial DC the peripheral blood DC from both patients with rheumatoid arthritis and normal controls released less IL-1 activity than peripheral blood monocytes did. Inhibition with an antiserum to IL-1 revealed that IL-1 production is important for the accessory activity of the peripheral blood DC. Thus human DC from inflammatory sites and peripheral blood produce IL-1 activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1986.tb01977.x
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  • 3
    Electronic Resource
    Electronic Resource
    Total and peripheral bone mass in patients with psoriatic arthritis and rheumatoid arthritis (1986)
    Springer
    Clinical rheumatology 5 (1986), S. 372-378 
    Details
    ISSN: 1434-9949
    Keywords: Psoriatic Arthritis ; Rheumatoid Arthritis ; Bone Mass ; Total Body Calcium ; Metacarpal Indices
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Psoriatic arthritis is thought to be associated with periarticular osteoporosis while rheumatoid arthritis may be associated with generalised as well as periarticular bone loss. To assess the extent of total and peripheral bone loss in these two diseases, total body calcium was measured by in vivo neutron activation analysis and peripheral bone mass was assessed by metacarpal indices in age-matched patients with psoriatic arthritis and rheumatoid arthritis treated with nonsteroidal anti-inflammatory drugs alone. In comparison with age and sex-matched normal controls, total and peripheral bone mass was normal in psoriatic arthritis. There were significant reductions in total (6.2% in men; 7.9% in women) and peripheral (10.9% in men; 12.8% in women) bone mass in patients with rheumatoid arthritis compared with controls. Peripheral bone mass was significantly correlated with the degree of radiographic damage in male and female patients with rheumatoid arthritis. The mean annual loss of total body calcium was insignificant in psoriatic arthritis (0.6% in men; 1.9% in women) but markedly greater in rheumatoid arthritis (4.4% in men; 2.7% in women). The data suggested that total and peripheral bone loss is greater in rheumatoid arthritis than psoriatic arthritis. Substantial reductions in peripheral bone mass in patients with rheumatoid arthritis not receiving corticosteroids may account in part for the small reductions in total bone mass.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02054256
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  • 4
    Electronic Resource
    Electronic Resource
    Distribution of an anti-DNA idiotype among autoantibodies in patients with systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA) (1986)
    Springer
    Journal of clinical immunology 6 (1986), S. 292-298 
    Details
    ISSN: 1573-2592
    Keywords: Autoantibodies ; SLE ; RA ; anti-ANA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Autoantibodies from patients with systemic lupus erythematosus, rheumatoid arthritis, or other connective tissue disorders were probed for the presence of a cross-reactive idiotype (AM Id) originally defined on human anti-double-stranded DNA antibodies. The AM Id was distributed primarily among antibodies to double-stranded DNA, single-stranded DNA, or cardiolipin in patients with systemic lupus erythematosus and antibodies to single-stranded DNA or cardiolipin and rheumatoid factor in patients with rheumatoid arthritis, thus tending to codistribute with the predominant primary autoantibodies in both diseases. Strong associations were observed particularly between the AM Id and anti-single-stranded DNA antibodies in patients with systemic lupus erythematosus and the AM Id and anticardiolipin antibodies in patients with rheumatoid arthritis. Affinity absorption experiments with sera from individual lupus patients showed that up to 41% of the anti-single-stranded DNA antibodies were Id positive. The results indicate that the AM Id may be widely distributed among antibodies that have a potential for binding DNA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00917329
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  • 5
    Electronic Resource
    Electronic Resource
    Hypoxanthine-guanine phosphoribosyltransferase deficiency in three brothers with gout: Characterization of a variant, HPRTEdinburgh, having altered isoelectric point, increased thermal lability and normal levels of messenger RNA (1989)
    Springer
    Journal of inherited metabolic disease 12 (1989), S. 390-402 
    Details
    ISSN: 1573-2665
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Three brothers who developed acute gouty arthritis at ages 16, 20 and 26 years were found to have increased plasma urate. Erythrocyte hypoxanthine phosphoribosyltransferase (HPRT) activity was less than 1% of normal and adenine phosphoribosyltransferase (APRT) activity was increased 2–3-fold. This variant, HPRTEdinburgh, was further studied using lymphoblast lines established from these patients and the following observations are consistent with a mutation involving a single amino acid substitution. Lymphoblasts from these patients had 0.9–1.6% of control HPRT activity which was 8-fold more labile than control activity at 75°C. Isoelectric focusing of the variant protein in polyacrylamide gels indicated a pI of 6.5–6.7 which is more basic than normal HPRT, pI 6.0–6.3. The Michaelis constants were increased: 10-fold for hypoxanthine from 1.3 to 13 µmol/L, and 5-fold for PP-ribose-P from 6 to 30 µmol/L, for control and variant respectively. TheK i for product inhibition by GMP was marginally increased in the variant. Northern blot analysis of variant lymphoblast RNA indicated normal amounts of the expected 1.6 kilobase messenger RNA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01802034
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    Paper (German National Licenses)
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