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  • 1
    Electronic Resource
    Electronic Resource
    Amyloid deposition in basal cell carcinoma: a cause of apparent lack of sensitivity to radiotherapy (2001)
    Oxford, UK : Blackwell Science Ltd
    Clinical and experimental dermatology 26 (2001), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We describe a patient with a large nodular basal cell carcinoma (BCC), which was excised following apparent failure to respond to radiotherapy. Histological examination of the fully excised lesion demonstrated a solid mass of amyloid, which stained positively for cytokeratins, but there was no residual BCC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2230.2001.00875.x
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  • 2
    Electronic Resource
    Electronic Resource
    Integrated materials science facility on the SRS : INTERNATIONAL CONFERENCE ON SYNCHROTRON RADIATION INSTRUMENTATION (1989)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 60 (1989), S. 1897-1900 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The development of a new integrated materials science facility (station 9.3) on the wiggler line of the Daresbury Synchrotron Radiation Source is outlined. The facility combines instrumentation for data acquisition using both spectroscopic (XANES and EXAFS) and diffraction techniques and is optimized towards industrial applications such as catalysis and electrochemistry using in situ techniques.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1140883
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  • 3
    Electronic Resource
    Electronic Resource
    Status epilepticus following enflurane anaesthesia (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 41 (1986), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Two patients had generalised convulsions which occurred several hours afer anaesthesia supplemented with enpurane. One patient had to be treated for life threatening status epilepticus 7 hours after anaesthesia and the other had a myoclonic convulsion 17 hours after recovery from anaesthesia. Neither had any relevant pre-operative history of epilepsy or convulsions. Possible synergistic roles of the metabolite of atracurium. laudanosine, as well as of cephazolin and photic stimulation, are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1986.tb12918.x
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  • 4
    Electronic Resource
    Electronic Resource
    Anaesthetic management of glucagonoma (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 40 (1985), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Alpha cell tumours of the pancreatic islets of Langerhans are rare. The glucagonoma syndrome is caused by excess glucagon secretion from such a tumour. Physiologically, glucagon is important in the control of the homeostasis of glucose and certain amino acids. Pharmacologically, it has been used to treat heart failure. Problems with both glucose homeostasis and myocardial function could, therefore, theoretically be anticipated following resection of a glucagonoma. This paper describes the peri-operative management of such a case, where, despite measured changes in glucagon, no problems of this nature were encountered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1985.tb10706.x
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  • 5
    Electronic Resource
    Electronic Resource
    The surgery of infancy—I (1998)
    Oxford, UK : Blackwell Science Ltd
    Pediatric anesthesia 8 (1998), S. 0 
    Details
    ISSN: 1460-9592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9592.1998.00534.x
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  • 6
    Electronic Resource
    Electronic Resource
    Logarithmic SI (1982)
    [s.l.] : Nature Publishing Group
    Nature 297 (1982), S. 450-450 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - I have for some time made private use of a notation for expressing numbers and measurements that others might perhaps also find useful. It was suggested to me by the symbol "/?H". The first step is to let the prefix p mean "antilog to the base 10". So pO is 1, p6 is 1,000,000; 2,000 is 2p3 ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/297450b0
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  • 7
    Electronic Resource
    Electronic Resource
    Amyloid β-Protein, APOE Genotype and Head Injury (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 777 (1996), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Notes: Deposition of amyloid β-protein (Aβ) in the brain plays a key role in the pathogenesis of Alzheimer's disease. Head injury is an epidemiological risk factor for Alzheimer's disease, and deposition of Aβ occurs in approximately one third of individuals dying shortly after a severe head injury. Of the three common apolipoprotein E alleles (APOE-ε2, ε3, and ε4) APOE-ε4 allele is a strong risk factor for both sporadic and some familial cases of Alzheimer's disease and there is in vitro evidence that apolipoprotein E is directly involved in Aβ deposition. We have examined the frequency of APOE-ε4 in those individuals with Aβ deposition following head injury and found that the APOE-ε4 frequency (0.52) is higher than in most studies of sporadic Alzheimer's disease. In those head-injured individuals without amyloid deposition the APOE-ε4 frequency (0.16) is similar to that in non-Alzheimer's disease controls (p 〈 0.00001). Our data indicate an interaction between known environmental and genetic risk factors for Alzheimer's disease and underlines the importance of convergence of data around the common mechanism of Aβ deposition. Furthermore, it indicates a genetic susceptibility to the effects of a head injury which may be of significance both to those who have recently sustained such an injury and to those whose activities put them at risk of trauma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1996.tb34431.x
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  • 8
    Electronic Resource
    Electronic Resource
    The nature of the redshift and directly observed quasar statistics (1991)
    Springer
    Naturwissenschaften 78 (1991), S. 289-296 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Notes: Abstract The nature of the cosmic redshift is one of the most fundamental questions in modern science. Hubble's discovery of the apparent Expansion of the Universe is derived from observations on a small number of galaxies at very low redshifts. Today, quasar redshifts have a range more than 1000 times greater than those in Hubble's sample, and represent more than 100 times as many objects. A recent comprehensive compilation of published measurements provides the basis for a study indicating that quasar observations are not in good agreement with the original predictions of the Expanding Universe theory, but are well fit by the predictions of an alternative theory having fewer adjustable parameters.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01221413
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  • 9
    Electronic Resource
    Electronic Resource
    The mononuclear cell infiltrate compared with survival in high-grade astrocytomas (1989)
    Springer
    Acta neuropathologica 78 (1989), S. 189-193 
    Details
    ISSN: 1432-0533
    Keywords: Astrocytoma ; Macrophage ; Lymphocyte ; Mononuclear cells ; Survival
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Frozen samples from 92 malignant astrocytomas were stained with a panel of monoclonal antibodies directed against macrophages and lymphocytes. A follow-up to death was available on 68 cases which form the basis of this study. Large numbers of macrophages were found in all cases; T lymphocytes, mostly of the CD8 phenotype were also seen in moderate numbers in 70% of cases. CD4-positive cells were present in small numbers in 32% and B cells were seen in only 8% of cases. Analysis of the survival showed no demonstrable correlation between the numbers of macrophages or CD4 lymphocytes and survival. The survival curves for parencymal CD8 infiltration diverged after 9 months suggesting increased survival for those patients without such an infiltration but the difference failed to reach statistical significance (P=0.37). No correlation between lymphocytic cuffing and survival was seen after studying all paraffinembedded material. We conclude that there is no significant statistical correlation between survival and the various types of mononuclear cell infiltrating malignant astrocytomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688208
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  • 10
    Electronic Resource
    Electronic Resource
    Neuronal cytoskeletal changes are an early consequence of repetitive head injury (1999)
    Springer
    Acta neuropathologica 98 (1999), S. 171-178 
    Details
    ISSN: 1432-0533
    Keywords: Key words Head injury ; Chronic traumatic brain ; injury ; Neurofibrillary tangles ; Dementia pugilistica ; Hyperphosphorylation of tau
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract While neuropathological studies have established the pathology of dementia pugilistica to be similar to that of Alzheimer’s disease, there is little information about the early histological changes caused by the repetitive trauma that eventually produces dementia pugilistica. We have examined the brains of four young men and a frontal lobectomy specimen from a fifth, age range 23– 28 years, all of whom suffered mild chronic head injury. There were two boxers, a footballer, a mentally subnormal man with a long history of head banging, and an epileptic patient who repeatedly hit his head during seizures. The four autopsy cases were widely sampled; the lobectomy specimen was serially sliced after fixation. Routine stains were performed; immunostaining included β-amyloid precursor protein, amyloid β-protein (Aβ), tau and apolipoprotein E (apoE). Pathological findings in all five cases were of neocortical neurofibrillary tangles (NFTs) and neuropil threads, with groups of tangles consistently situated around blood vessels in the worst affected regions. No Aβ immunoreactivity was detected. The amount of neuronal apoE expression varied widely between the cases with no clear relation to the NFTs. The apoE genotype was determined in only two cases (both ɛ3/ɛ3). It appears that repetitive head injury in young adults is initially associated with neocortical NFT formation in the absence of Aβ deposition. The distribution of the tau pathology suggests that the pathogenesis of cytoskeletal abnormalities may involve damage to blood vessels or perivascular elements.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010051066
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