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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Inflammation research 28 (1989), S. 164-167 
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This kinetic study was performed to investigate the different tissue-influencing histamine amounts in Crohn's Disease (CD), Ulcerative Colitis (UC), patients with polyps and cancers (P.a.C.Gr) and in a Control Group (CG). For this purpose the endoscopically obtained specimens from rectal mucosa were immediately placed into 1000 μl of Hank's incubation medium in order to determine the spontaneously released histamine amounts at the time points of 5,10,15, 20 and 30 minutes. Each time a volume of 100 μl was removed from the incubation medium and the kinetic value (KV) was detected by using the single isotope radioenzymatic method. Influencing of natural histamine catabolism and the comparison of the tissue histamine release with or withour air oxygen in the incubation medium using four kinetic programmes (KP 1-4) provides clearly different KVs, not only betwen the KPs but also within the same KP. The P.a.C.Gr. shows higher kinetic values (KVs) compared with the CG. In KP 1-3 the kinetic courses (KCs) of the Inflammatory Bowel Diseases (IBDs), CD and UC-both not yet divided in active (a.) or not active (n.a.) disease stages-cross the KCs of the CG several times. Only the differentiation of the IBDs in active and not active disease stages in KP4 reveals that CDa. and UCa. stand out from the CG by higher KVs, and in contrast, CDn. a. and UCn.a. have lower KVs than the CG. The released amounts of histamine in CDa. and UCa. are significantly higher than in CDn.a. and UCn.a.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Inflammation research 27 (1989), S. 89-92 
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Testing of tissue particles for mediator release may be very useful for the diagnosis of localized immunological abnormalities or allergies. The aim of this study was to set up a general procedure to test the reaction of large bowel mucosa to stimuli via the IgE-mediated pathway. Therefore, tissue particles from normal subjects and from patients suffering from different diseases (Crohn's disease, ulcerative colitis, intestinal polyps) obtained at routine coloscopy were exposed to either Hanks or anti-IgE solution to determine the spontaneous or the anti-IgE-induced histamine release, expressed as the percentage of the total histamine content of the biopsy. Histamine was measured using the single isotope radioenzymatic assay. In general, whereas anti-IgE interestingly reduced the histamine release compared to the spontaneous in most of the patients within the polyps group, there was a stimulating effect of anti-IgE throughout all other groups. Thus, the study confirms the possibility of performing functional tests using biopsy particles from the colon.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Archives of toxicology 59 (1986), S. 61-63 
    ISSN: 1432-0738
    Keywords: Acute selenium poisoning ; Normal selenium values ; Analytical procedure ; Industrial accident
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Neutralizing selenic acid with caustic soda caused a hyperintensive exothermic reaction, with about 450 1 of the reaction mixture erupting in a factory hall. A 44-year-old industrial worker was fatally intoxicated, suffering from second-degree skin burns, necrosis of oral mucous membranes and hemorrhagic lung edema. He died 90 min later. Analysis of body fluids and tissue samples showed high selenium concentrations in blood serum, urine, stomach content and lungs. The analytical results are discussed in comparison with normal selenium levels of non-exposed groups.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    International archives of occupational and environmental health 60 (1988), S. 55-66 
    ISSN: 1432-1246
    Keywords: Nickel ; Chromium ; Lung tissue ; Norm values ; Occupational exposure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Nickel (Ni) and some of its relatively insoluble compounds as well as chromates may be able to induce cancer in the region of the lungs, as well as in the nose and paranasal sinuses after occupational exposure. Latency periods may amount to 20 years and more. The results of recent investigations have shown that these metals cumulate in the lung tissue after inhalation of relatively insoluble chromium and nickel compounds. The quantitative detection of these heavy metals in samples of pulmonary tissue hence permits the amount of past exposure to be estimated. To establish the normal values, samples of pulmonary tissue from 30 normal subjects were investigated for chromium and nickel content. The samples were taken from different segments and lobes of the lungs, taking topographical anatomical criteria into consideration. In addition, 15 persons who had formerly been exposed to nickel and/or chromium (11 nickel refinery workers, of whom 10 had died of lung cancer, 2 stainless steel welders, 1 foundry worker, 1 electrical technician) were also investigated. From the results of 495 tissue samples from the normal group, median chromium concentrations between 130 and 280 ng/g were calculated, with median nickel concentrations of 20–40 ng/g (wet weight). If these values are related to the nickel concentrations measured in refinery workers, values 112-5,860 times higher were found. The concentrations were about 500 times higher than normal for nickel, and about 60 times higher than normal for chromium in the stainless steel welders. For the foundry workers who died of lung cancer, chromium and nickel concentrations in the normal range were calculated, with the exception of the nickel concentrations in the upper and lower lobes of the right lung. The very high nickel concentrations found in the samples of lung tissue from former nickel refinery workers should be regarded as a guideline with regard to the appraisal of the causal relationship between lung cancer and occupational exposure to relatively insoluble nickel compounds. This result is also supported by epidemiological investigations on this subgroup and must thus be considered etiologically conclusive. For the welders, chromium and nickel concentrations were found that were markedly above normal, but as yet there is no epidemiologically reliable verification for the increased occurrence of malignancies in this occupational group. On the basis of present scientific knowledge, no indications were found of relevant chromium and/or nickel exposure of the lung tissue that might be able to induce lung cancer in either foundry workers or for electric technicians.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    International archives of occupational and environmental health 61 (1989), S. 507-512 
    ISSN: 1432-1246
    Keywords: Ni- ; Cr-analyses ; Human lung tissue ; Lung cancer ; Expertise aspects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary After inhalative occupational exposure to certain compounds containing nickel and chromium (mostly over many years), an accumulation of these metals may occur in the lung tissue. This is of particular importance, both from a toxicological point of view and with regard to expert reports, since certain nickel and chromium compounds may induce lung cancers. In the context of this study, samples of pulmonary tissue from 34 deceased persons from the Bergen area (Norway) were analysed by atomic absorption spectrometry with regard to their content of chromium and nickel. The deceased comprised 21 men and 13 women. In 15 cases, death resulted from lung cancer; in the other 19 deceased, there was no indication of a malignant disease of the airways. The concentrations of nickel found in the lung tissue do not differ between patients with lung cancer and patients with healthy lungs. On the other hand, the concentration of chromium in the pulmonary tissue in the patients who had died of lung cancer and who had all been inhalative smokers, are higher (statistically significant) than in the nonsmokers or in those with healthy lungs. An accumulation of these two metals in the tumor matrix could not be detected. Both the average nickel and the average chromium concentrations were higher in the persons who had probably been exposed occupationally. Considering the present state of scientific knowledge, the aspects relevant to expert reports which result from the analyses of metals in the pulmonary tissue are discussed.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    International archives of occupational and environmental health 61 (1989), S. 527-541 
    ISSN: 1432-1246
    Keywords: Asbestos dust ; Asbestosis ; Health hazards ; Preventive medical investigations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary For the period from 1973 to the end of 1986, 70656 data sets on occupational preventive medical examinations in employees exposed occupationally to asbestos dust (G 1.2) were made available to us by the Central Registry for Employees Exposed to Asbestos Dust (ZAS). On the basis of this data, an analysis of asbestosis risk was to be made in relation to specific areas of work, taking into consideration the beginning and duration of exposure. Proceedings for declaratory appraisal in accordance with occupational disease no. 4103 were instituted in 1760 cases in the report period. In accordance with the character of the available data, the X-ray findings in the lungs were available from the persons investigated as parameters of possible asbestosis risk on the basis of coding consistent with the International Pneumoconiosis Classification (ILO U/C 1971 and/or ILO 1980 West Germany). The major result of the statistical analyses on the mainframe macrocomputer of the University of Erlangen-Nuremberg was that the relatively highest risk of asbestosis was present in persons whose exposure began before 1955. On the other hand, with increasing duration of exposure, an unequivocal rise of the asbestosis risk could not be detected on the basis of the overall population. In relation to the individual fields of work, the relatively highest risk of asbestosis was shown to be in the asbestos textile and paper industry, as well as in the asbestos cement industry. No detectable risk of asbestosis was present in the fields of mining, traffic and health service and for women in the industrial sectors of building material, gas and water, catering trade, building, commerce as well as banking and insurance. Accordingly, it can be assumed that certain fields of work are or were exposed to such a small extent or not at all that a risk of asbestosis which is relevant in terms of occupational medicine is no longer to be assumed or was not to be assumed. This applies above all to certain work in the frictional coating (brake lining) and asbestos paper industry. Furthermore, the analysis of the data material did not provide any unequivocal indications that inhalative smoking habits have a negative effect on the risk of asbestosis. In prinicple, it can be stated that the occupational preventive medical investigations according to G 1.2 are effective. However, irrespective of this, the analysis has shown that a regular exchange of experience on the part of authorized physicians should be institutionalized and the second X-ray appraisal should be retained in order to ensure a high measure of reliability and diagnostic relevance of the available investigation data. Besides this, all expert appraisal results from patients with recognized occupational diseases according to subparagraphs, 4103, 4104 and 4105 BeKV (no. 4103: asbestosis, no. 4104: asbestosis in connection with lung cancer, no. 4105: mesothelioma of the pleura or peritoneum) should be centrally registered both in persons exposed to asbestos dust and in persons with asbestosis and accompanying malignant diseases, would then be possible.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 369 (1986), S. 349-353 
    ISSN: 1435-2451
    Keywords: Aortic aneurysm ; High age ; Mortality ; Morbidity ; Aortenaneurysma ; Hohes Alter ; Mortalität ; Morbidität
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Von August 1984–August 1985 wurden am Klinikum Nürnberg 118 abdominelle Aortenaneurysmen operiert. Das Durchschnittsalter betrug 68,9 Jahre, 26,3% der Patienten waren über 75 Jahre. Die Elektivoperationen waren in der höchsten Altersgruppe deutlich rückläufig; kardiale Rhythmusstörungen und renale Insuffizienz waren die häufigsten Risikofaktoren. Die Letalität bei Elektiveingriffen war 0%, 50% bei symptomatischen and 〉 50% bei perforierten Aneurysmen im hohen Alter. Die hohe Letalität im Stadium der Ruptur rechtfertigt den Elektiveingriff bei Aortenaneurysmen im hohen Alter.
    Notes: Summary From August 1984–August 1985 118 abdominal aortic aneurysms were treated surgically in the City Hospital Nuremberg. The mean age was 68.9 years, with 26.3% being over 75 y.; and there was a notable decline of elective procedures in this group, which was particularly jeopardized by cardial arrhythmias and renal insufficiency. The lethality was 0 in elective procedures, but reached 50% for symptomatic and over 50% for perforated aneurysms in the old age group. The high lethality of ruptured aortic aneurysms justify elective operation of aortic aneurysms in high age.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1435-2451
    Keywords: Cerebrovascular disease ; Carotid endarterectomy ; Contralateral occlusion ; Cerebrovasculäre Insuffizienz ; Carotisrekonstruktion ; Kontralateraler Verschluß
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Von Dezember 1974 bis März 1985 wurden 244 Carotisrekonstruktionen bei kontralateralem InternaverschluB durchgeführt. 7,3% der Patienten befanden sich im Stadium I, 48,4% im Stadium II und 44,3% im Stadium IV der cerebrovasculären Insuffizienz. Ein Shunt wurde in 5,4% eingelegt. Das post- /perioperative permanente neurologische Defizit betrug 3,3%, die Letalitat 2,0%. Die kumulierte Überlebensrate für das Gesamtkollektiv nach 5 Jahren erreichte 65,2±4,8%, ein signifikanter Unterschied zwischen Stadium II und IV bestand nicht. 9,2% der Patienten erlitten bis zu 103 Monaten nach der Operation einen Schlaganfall.
    Notes: Summary Between December 1974 and March 1985 244 reconstructions of the internal carotid artery with contralateral occlusion were performed. 7.3% of the patients were asymptomatic, 48.4% had typical transient ischemic attacks and 44.3% had a completed stroke. The postoperative mortality was 2.0% and a permanent neurologic deficit occurred in 3.3%. An intraluminal shunt was used in only 5.4%. The long-term survival rate after 5 years was 65.2±4.8%. In the follow-up period of 103 months 9.2% of the patients had a new stroke.
    Type of Medium: Electronic Resource
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