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  • 1
    Electronic Resource
    Electronic Resource
    A Distibution of Activation Energy for Recovery between 50 and 85K in Deformed Aluminum (1987)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 15-18 (Jan. 1987), p. 789-794 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/00/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.15-18.789.pdf
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  • 2
    Electronic Resource
    Electronic Resource
    Alzheimer's neurofibrillary tangles are penetrated by astroglial processes and appear eosinophilic in their final stages (1987)
    Springer
    Acta neuropathologica 72 (1987), S. 214-217 
    Details
    ISSN: 1432-0533
    Keywords: Neurofibrillary tangles ; Senile dementia of Alzheimer type ; Glial fibrillary acidic protein ; Astrocytes ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Alzheimer's neurofibrillary tangles (ANT) in the hippocampal area were studied immunohistochemically using antisera against glial fibrillary acidic protein (GFAP) and S-100 protein in 48 patients with or without dementia between 52 and 92 years old. In 27 of the 38 brains that developed ANT in the hippocampal area, some ANT were immunostained with these antisera. Flame-shaped or globose-shaped immunostains were occasionally continuous with astroglial cell bodies and processes. They appeared particularly in the entorhinal cortex, subiculum and CAl. The ANT, immunostained with GFAP and S-100 antisera, apparently correspond to slightly eosinophilic tangles in H&E sections and to less argentophilic tangles in silver-impregnated sections in all of the 27 brains. ANT of another 11 brains were consistently negative with these antisera. The GFAP-positive eosinophilic tangles were encountered in the brains of older patients (P〈0.01) and with more abundant formation of ANT (P〈0.001). This alteration was present in all of the 20 brains with more than 100 ANT per section and none of the eight brains with less than 10 ANT. These findings suggest that in the last stages, ANT are penetrated by eosinophilic processes of astrocytes, and appear eosinophilic, and that the presence of GFAP-positive eosinophilic tangles indicates the abundant formation of ANT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691092
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  • 3
    Electronic Resource
    Electronic Resource
    Diffuse type of senile plaques in the cerebellum of Alzheimer-type dementia demonstrated byβ protein immunostain (1989)
    Springer
    Acta neuropathologica 77 (1989), S. 314-319 
    Details
    ISSN: 1432-0533
    Keywords: Alzheimer-type dementia ; Senile plaques ; β Protein ; Formic acid treatment ; Cerebellum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We studied senile plaques (SP) in the cerebella of six autopsied subjects with Alzheimer-type dementia (ATD) and ten non-ATD autopsied subjects between the ages of 78 and 90. Neither SP nor amyloid angiopathy (AA) was observed in any of the non-ATD subjects. In the four of the six ATD subjects, diffuse plaques in the molecular layer were seen as ill-defined areas of fine fibrillar materials by β protein immunostaining with formic acid pretreatment, the modified Bielschowsky stain, and periodic acid-methenamine silver (PAM) stain. The plaques were not visible with Bodian, Congo red, or periodic acid-Schiff stains. Compact plaques in the Purkinje cell or in the granular cell layers were found in three of the six subjects. Their amyloid core was often surrounded by areolar amyloid deposits. AA was observed in three of the six subjects. The argyrophilia of the diffuse and compact plaques, demonstrated by the modified Bielschowsky and PAM stains, became undetectable when the sections were first treated with formic acid. Such treatment made the plaques immunoreactive with β protein antiserum. The findings suggested that cerebellar diffuse plaques and compact plaques consist mainly of an amyloid component, and are characteristic of ATD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687584
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  • 4
    Electronic Resource
    Electronic Resource
    A variety of cerebral amyloid deposits in the brains of the Alzheimer-type dementia demonstrated byβ protein immunostaining (1988)
    Springer
    Acta neuropathologica 76 (1988), S. 541-549 
    Details
    ISSN: 1432-0533
    Keywords: β Protein ; Senile plaques ; Amyloid ; Alzheimer ; Dementia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We studied cerebral amyloid deposits in the hippocampal area immunohistochemically, using antiserum to syntheticβ peptide (1–28) in 66 patients with or without dementia and aged 17 to 91 years old. Senile plaques (SP) and amyloid angiopathy (AA) were detected in 36 (55%) and 19 (29%) patients, respectively. Also, cerebral amyloid deposits from the brains of seven patients with dementia and five patients without were studied in serial sections stained with Bodian, modified Bielschowsky, Congo red, andβ protein immunostain. In the patients with Alzheimer-type dementia (ATD) diffuse plaques, typical of this group, were stained withβ protein antiserum but not with Bodian stain, because the plaques were devoid of abnormally swollen neuritic processes. The diffuse plaques often contained one or more neuronal cell bodies. As well as primitive and classic plaques and AA, theβ protein immunostain demonstrated small deposits among the SP, small stellate deposits of layer 1, subpial fibrillar deposits, and focal cribriform deposits of parasubiculum, which may be new types of amyloid deposits. Amyloid plaques within the subcortical white matter were only found in ATD brains. In the non-demented patients various kinds of SP, including diffuse and compact ones, were immunostained. They tended to be small and few.β protein immunostain with formic acid pretreatment is a useful method for the identification of a variety of senile cerebral amyloid deposits.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00689591
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  • 5
    Electronic Resource
    Electronic Resource
    Diffuse type of senile plaques in the brains of Alzheimer-type dementia (1988)
    Springer
    Acta neuropathologica 77 (1988), S. 113-119 
    Details
    ISSN: 1432-0533
    Keywords: Senile plaques ; β protein ; Alzheimer-type dementia ; Bodian stain ; Senile cerebral amyloid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We studied the nature of diffuse type of senile plaques (SP) in the brains of six autopsied subjects with Alzheimer-type dementia (ATD). The densities of SP in the entorhinal cortex were evaluated using serial sections stained by four different methods. Compared with β protein immunostaining (100% as a reference), the modified Bielschowsky stain (103%) and the periodic acid-methenamine silver (PAM) stain (109%) labeled similar numbers of SP, whereas the Bodian stain labeled only a minor proportion (42%) of these. The vast majority of Bodian-negative plaques were diffuse plaques, which were seen as ill-defined areas of fine fibrillar material after β protein immunostain with formic acid pretreatment, modified Bielschowsky stain, and PAM stain. They were not stained by Congo red or periodic acid-Schiff stains. Double staining using Bodian and β protein methods demonstrated that diffuse plaques were free of swollen neurites. Argyrophilia of the diffuse plaques shown by the modified Bielschowsky and PAM stains, became undetectable when sections were pretreated with formic acid. Such treatment made the diffuse plaques immunoreactive to β protein antiserum, suggesting that diffuse plaques consisted mainly of amyloid, but not neuritic components. The diffuse plaques were distributed in various cortical areas and in the amygdala, and comprised a considerable population of the SP in the ATD brains.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687420
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  • 6
    Electronic Resource
    Electronic Resource
    Once daily administration of terbinafine to guinea-pigs with experimental dermatophytosis (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 14 (1989), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1989.tb00903.x
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  • 7
    Electronic Resource
    Electronic Resource
    The alteration in the pattern of pulmonary metastasis with adjuvant chemotherapy in osteosarcoma (1988)
    Springer
    International orthopaedics 12 (1988), S. 305-308 
    Details
    ISSN: 1432-5195
    Keywords: Osteosarcoma ; Pulmonary metastasis ; Adjuvant chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé On a étudié les modifications de l'aspect des métastases pulmonaires chez des malades porteurs d'un ostéosarcome et traités par chimiothérapie complémentaire. Trente-deux malades traités à la fois par chirurgie radicale et chimiothérapie ont été examinés (groupe avec chimiothérapie). Soixante-deux malades traités seulement par chirurgie radicale (groupe sans chimiothérapie) ont également été suivis, constituant un groupe de contrôle. Le groupe avec chimiothérapie a présenté une diminution du nombre ainsi qu'un retard à l'apparition des métastases. Le temps de doublement de ces tumeurs ne diffère pas entre les deux groupes. La localisation initiale des métastases dans le groupe avec chimiothérapie est le plus souvent la base du poumon, tandis que dans le groupe sans chimiothérapie c'est habituellement la partie moyenne du poumon. Après apparition des métastases pulmonaires la durée de survie est plus importante dans le groupe avec chimiothérapie que dans l'autre. L'examen histologique montre que les foyers métastatiques sont identiques à la localisation initiale de la tumeur.
    Notes: Summary Alterations in the pattern of pulmonary metastasis of patients with osteosarcoma treated with adjuvant chemotherapy were studied. Thirty two patients who were treated with both radical surgery and adjuvant chemotherapy were observed (chemotherapy group). As a control, sixty two patients treated with radical surgery alone were also assessed (non-chemotherapy group). The chemotherapy group demonstrated a reduction in the number and a delay in the appearance of metastases. The tumour doubling time did not differ between the chemotherapy and non-chemotherapy groups. The initial site of metastasis among the chemotherapy group was most commonly in the lower lung field, whereas among the non-chemotherapy group it was usually to the middle lung field. The chemotherapy group survived longer than the non-chemotherapy group after developing pulmonary metastases. Histological examination showed that the metastatic foci simulated the primary sites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00317829
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  • 8
    Electronic Resource
    Electronic Resource
    NaCl-aided Hoechst 33258 staining method for DNA quantification and its application (1989)
    Springer
    Histochemistry and cell biology 92 (1989), S. 65-68 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary We investigated the effect of salt on the fluorescence staining procedure for quantification of the amount of DNA in cell nuclei in situ. For this, NaCl was added at various concentrations to the Hoechst 33258 fluorochrome (Hoe) medium for staining DNA. The fluorescence intensity of free DNA-Hoe solution was not changed by the addition of NaCl, but that of the nuclei-Hoe complex in situ increased 4-fold on increasing the NaCl concentration up to 1 M. SDS polyacrylamide gel electrophoresis showed that histones H1, H2A, and H2B dissociated from cell nuclei in the presence of 1 M NaCl, resulting in increasing accessibility of DNA to the fluorochrome. The applicability of the NaCl-aided fluorescence staining method was evaluated by measuring the ploidy classes of various cells. The amount of DNA in spermatozoa is half that in 2n hepatocytes, but by the conventional Hoe staining procedure the fluorescence intensity of spermatozoa is higher than that of 2n hepatocytes, due to differences in accessibility of the dye to DNA. In contrast, by the NaCl-aided procedure, the fluorescence intensity of 2n hepatocytes was twice that of spermatozoa. The effectiveness of the NaCl-aided Hoe staining method was checked using cultivated human gingival cells and hepatocytes of LEC rats with hereditary hepatitis. In all cases, reasonable proportionality between the fluorescence intensity and the amount of DNA was observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00495018
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  • 9
    Electronic Resource
    Electronic Resource
    Family study and frequency of blood group with strong B transferase accompanied by decreased A and H antigens (1989)
    Springer
    Annals of hematology 59 (1989), S. 157-161 
    Details
    ISSN: 1432-0584
    Keywords: α-galactosyltransferase ; α-N-acetyl-D-galactosaminyltransferase ; A2 ; B-transferase ; Weak H antigen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Subgroups of type A blood, named A1, A2 and A1–A2 intermediate (Aint), are specifically characterized by their peculiar A alleles and have their own A1-, A2- or Aint-forms of α-N-acetyl-D-galactosaminyltransferase (A-transferase). It is known, however, that certain type A2B persons exhibit A1-transferase. The reason may be an unusual α-galactosyltransferase (B-transferase). This strong B-transferase competes with A-transferase for the substrate, H antigen, so as to decrease the A and H antigens on the red cells. We studied this blood group over three generations and found that the strong B-transferase is, in fact, inherited with the B gene and is dominant over normal B-transferase. In AB blood groups in Tokyo, the frequency of people with a strong B-transferase is 5% for A1B and 22% for A2B. This enzyme does not always cause weak H or A antigens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320060
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  • 10
    Electronic Resource
    Electronic Resource
    Interaction of agonists and selective antagonists with gastric smooth muscle muscarinic receptors (1989)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 339 (1989), S. 145-151 
    Details
    ISSN: 1432-1912
    Keywords: Smooth muscle ; Muscarinic receptors ; G Proteins ; Selective antagonists
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The interaction of cholinergic agonists and antagonists with smooth muscle muscarinic receptors has been investigated by measurement of displacement of the muscarinic antagonist [3H]QNB (quinuclidinyl benzilate) in membranes prepared from toad stomach. The binding of [3H]QNB was saturable, reversible and of high affinity (K D = 423 pM). The muscarinic receptor subtypes present in gastric smooth muscle were classified by determining the relative affinities for the selective antagonists pirenzepine (M1), AF-DX 116 (M2) and 4-DAMP (M3). The results from these studies indicate the presence of a heterogeneous population of muscarinic receptor subtypes, with a majority (88%) exhibiting characteristics of M3 receptors and a much smaller population (12%) exhibiting characteristics of M2 receptors. The binding curve for the displacement of [3H]QNB binding by the agonist oxotremorine was complex and was consistent with presence of two affinity states: 24% of the receptors had a high affinity (K D = 4.7 nM) for oxotremorine and 76% displayed nearly a 1,000-fold lower affinity (K D = 4.4 μM). When oxotremorine displacement of [3H]QNB binding was determined in the presence GTPγS, high affinity binding was abolished, indicating that high affinity agonist binding may represent receptors coupled to G proteins. Moreover, pertussis toxin pretreatment of membranes also abolished high affinity agonist binding, indicating that the muscarinic receptors are coupled to pertussis toxin-sensitive G proteins. Reaction of smooth muscle membranes with pertussis toxin in the presence [32P]NAD caused the [32P]-labelling of a 40 kD protein that may represent the α subunit(s) of G proteins that are known to be NAD-ribosylated by the toxin. We conclude that both M3 and M2 receptors may be coupled to G proteins in a pertussis-sensitive manner.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00165136
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