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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 65 (1987), S. 375-375 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 65 (1987), S. 436-436 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0738
    Keywords: Chrysene ; Metabolism ; Excretion (urinary and faecal)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The urinary and faecal excretion of chrysene and its phenolic metabolites after oral, intraperitoneal, intratracheal, and intrapulmonary administration to rats have been studied by means of gas chromatography/mass spectrometry. The metabolite profile was found to depend on the mode of excretion and on the route of administration. In all cases the oxidation of chrysene in the 1,2- or 3,4-position predominates, whereas oxidation in the 5,6-position (K-region) seems be a minor pathway.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 115 (1989), S. 543-549 
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A carcinogenicity bioassay of 2-ethylhexyl acrylate (2-EHA) was conducted by applying 25 μl 86.5%, 21%, or 2.5% 2-EHA in acetone three times a week to the clipped dorsal skin of male C2H/HeJ mice (80 per group) over their lifetime. Another group was treated with a 43% 2-EHA solution for 24 weeks and thereafter observed for lifetime (stop-test). An untreated group and a group that received only the diluent acetone served as controls. Treatment-related changes in the skin indicative of irritation (scaling, scabbing, hyperkeratosis, hyperplasia) were found in all 2-EHA-treated groups. These lesions were reversible in the 43% group immediately after treatment was stopped, and in the 2.5% group after the 11 th week of treatment. Only in the 86.5% and 21% test groups showing chronic irritative skin damage was there a high incidence of nepolastic skin lesions (papillomas, carcinomas, and melanomas) with no dose dependency. In contrast, no skin tumors were found in the control groups, in the group treated with 2.5% 2-EHA for lifetime or in the group treated with 43% 2-EHA for about 6 months and observed for lifetime.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 371 (1987), S. 193-200 
    ISSN: 1435-2451
    Keywords: Right colon carcinoma ; Tumor colitis ; Prognosis ; Tumor defence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In einer retrospektiven Studie von 752 Patienten mit Coloncarcinomen der Jahre 1966 bis 1985 konnten 189 Tumoren des Rechtscolons und 563 Linkscarcinome erfaßt werden. Die globalen 5-Jahres-Überlebensquoten, das Stadienraster nach Dukes und die Operationsletalität waren in beiden Gruppen gleich. Bei einer höheren durchschnittlichen Tumorgröße, um 3 Monate längeren diagnostischen Verschleppungszeit und doppelt so hohen Rate an entdifferenzierten Carcinomen muß der Verlauf des Rechtstumors dennoch als relativ gutartiger eingestuft werden. Als Ursache für diese relativ bessere, lokale Tumorabwehr werden die dichtere Vascularisierung und Versorgung des Rechtscolons mit Lymphgefäßen sowie mucosale Mechanismen diskutiert. Ausdruck dieser angenommenen Abwehrreaktion ist eine nur im Rechtscolon beobachtete, heftige Tumorcolitis. Im Bestreben um die Verbesserung der Behandlungsergebnisse der Rechtscolontumoren kommt der Carcinomfrüherkennung, vor allem durch breite Ausschöpfung endoskopischer Möglichkeiten bei hämoccultpositiven Patienten, besondere Bedeutung zu.
    Notes: Summary 752 patients with colon carcinoma of the years 1966–1985 were studied retrospectively. 189 tumors were located in the right and 563 in the left colon. There was no difference in the 5-year survival rate, Dukes classification and operative mortality in both groups. Considering the higher median of tumor diameter, the three months longer diagnostic delay and the twice higher rate of undifferentiated carcinomas the prognosis of the right sided tumors is relatively better. In our opinion the cause of this more efficient local tumor defence is the better blood and lymph supply of the right colon and mucosal mechanisms. Expression of this better tumor defence is the distinct tumor colitis in the right colon. Improvement of the right colon carcinoma prognosis is to be expected of earlier tumor diagnosis. Routine endoscopic evaluation of hemocult positive subjects is most helpful.
    Type of Medium: Electronic Resource
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