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  • 1
    Electronic Resource
    Electronic Resource
    Insulin degradation. XXVIII. Immunocytochemical localization of glutathione-insulin transhydrogenase in the pancreas, kidney and liver of normal and streptozotocin-diabetic rats and of lean and obese (ob/ob) mice (1981)
    Springer
    Diabetologia 21 (1981), S. 464-469 
    Details
    ISSN: 1432-0428
    Keywords: Immunocytochemistry ; glutathione-insulin transhydrogenase ; thioliprotein-disulphide oxidoreductase ; streptozotocin-diabetic rats ; obese (ob/ob) mice ; pancreatic acini ; islets of Langerhans ; kidney tubules ; liver
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Glutathione-insulin transhydrogenase catalyzes the inactivation of insulin by splitting the hormone into A and B chains. We have localized this enzyme immunocytochemically by light microscopy in the pancreas, kidney and liver of both lean and obese (ob/ob) mice and similarly in normal and streptozotocin-diabetic rats. Localization was achieved by an antibody to glutathione-insulin transhydrogenase using a peroxidase-antiperoxidase technique. In comparison with tissues from control animals, positive immunostaining for glutathione-insulin transhydrogenase was increased in the obese mouse but reduced in the diabetic rat. Different tissues showed considerable variation in the amount of glutathioneinsulin transhydrogenase which could be detected. In the pancreatic islets there was little or no evidence for the presence of the enzyme in peripheral cells. In the kidney, immunocytochemical staining was found only in the proximal tubules. In the liver there was a generalised distribution of the enzyme, but the greatest concentration was in the periportal region. These observations parallel the biochemical data relating to glutathione-insulin transhydrogenase, indicating that different amounts of insulin degrading activity exist in different regions of tissues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00257787
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  • 2
    Electronic Resource
    Electronic Resource
    Calcium and inositol trisphosphate receptors (1995)
    Springer
    The journal of membrane biology 145 (1995), S. 109-118 
    Details
    ISSN: 1432-1424
    Keywords: Ca2+-induced Ca2+ release ; Ca2+ mobilization ; IP3 receptor ; Ryanodine receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237369
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  • 3
    Electronic Resource
    Electronic Resource
    Characteristic phenotype in congenital nephrotic syndrome (1995)
    Springer
    European journal of pediatrics 154 (1995), S. 239-240 
    Details
    ISSN: 1432-1076
    Keywords: Key words Congenital nephrotic syndrome ; Phenotype
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We present three children with congenital nephrotic syndrome and previously undescribed facial features. These include: (1) small mouth (intercommissural distance 〈 3rd percentile); (2) tented upper lip; (3) small nose (interalar distance –2 SD below mean); (4) fullness of cheeks giving a ’jowly' appearance; (5) overhanging outer thirds of upper eyelids. These features may reflect prolonged tissue oedema and protein malnutrition in utero and early life. Conclusion Characteristic facial features in congenital nephrotic syndrome may reflect intra-uterine malnutrition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01954281
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  • 4
    Electronic Resource
    Electronic Resource
    Characteristic phenotype in congenital nephrotic syndrome (1995)
    Springer
    European journal of pediatrics 154 (1995), S. 239-240 
    Details
    ISSN: 1432-1076
    Keywords: Congenital nephrotic syndrome ; Phenotype
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We present three children with congenital nephrotic syndrome and previously undescribed facial features. These include: (1) small mouth (intercommissural distance mouth (intercommissural distance 〈3rd percentile); (2) tented upper lip; (3) small nose (interalar distance −2 SD below mean); (4) fullness of cheeks giving a ‘jowly’ appearance; (5) overhanging outer thirds of upper eyelids. These features may reflect prolonged tissue oedema and protein malnutrition in utero and early life. Conclusion Characteristic facial features in congenital nephrotic syndrome may reflect intra-uterine malnutrition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01954281
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  • 5
    Electronic Resource
    Electronic Resource
    Fetal pathology in intrauterine death due to parvovirus B19 infection (1996)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 103 (1996), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To study the pathological features of fetuses dying because of parvovirus B19 infection, with particular reference to the presence of hydrops; to assess the usefulness of immunochemistry as a screening method for the detection of parvovirus infection at post-mortem examination.Design Review of clinical, sonographic, serological and pathological data; immunohistochemical staining of post-mortem tissue.Sample Cases of intrauterine fetal death occurring during the 18-month period January 1993 to June 1994 inclusive, referred for post-mortem examination to the Pathology Department, Royal Victoria Infirmary, Newcastle upon Tyne.Results Eleven cases of fetal death due to parvovirus infection were identified. Seven fetuses were less than 18-week size. Three fetuses showed conspicuous hydropic change. One of the 11 cases was detected for the first time by retrospective immunochemical screening. Of cases originating from the Newcastle district, parvovirus infection was responsible for about 10YO of all non-malformed fetal deaths occurring between 10 and 24 weeks of gestation referred for pathological examination.Conclusions During the period of study, parvovirus infection was a relatively common cause of mid-trimester fetal death. Many fetuses dying because of this infection are not noticeably hydropic, and the possibility of parvovirus infection should be considered in any case of intrauterine fetal death. Immunochemistry can be used to confirm the histopathological diagnosis, and may be of particular help where there is advanced autolysis; immunohistochemical screening may detect occasional cases not initially identified by examination of routinely stained tissue sections.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1996.tb09664.x
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  • 6
    Electronic Resource
    Electronic Resource
    Numerical simulation of viscous free surface flow (1998)
    Bradford : Emerald
    International journal of numerical methods for heat & fluid flow 8 (1998), S. 445-464 
    Details
    ISSN: 0961-5539
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Methods used to track the free surface in numerical flow simulations, typically during the casting of metals into moulds are examined in this paper. The algorithm employed makes use of a mixed interpolation formulation to approximate the discretised governing equations for elimination on a Langrangian type moving mesh. Significant savings in CPU time are realised by virtue of the the air domain not being considered in the finite element analysis. The advantages and drawbacks of commonly used methods are discussed, and a method proposed for the numerical simulation of flow where the free surface boundary conditions are important. The effectiveness of the proposed algorithm in solving typical industrial flow problems is demonstrated using numerical examples. The results obtained are compared with analytical and numerical data with a view to validating the algorithm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/09615539810213223
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  • 7
    Electronic Resource
    Electronic Resource
    Immunoperoxidase techniques applied to dermatopathology (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 10 (1983), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Immunoperoxidase techniques provide the pathologist with the capability for staining a wide range of antigens in tissue sections. More than 100 different antigens have been successfully demonstrated in fixed paraffin sections; other antigens can only lie visualized in frozen sections. This latter group particularly includes lymphocyte surface antigens detectable by monoclonal antibodies. This review describes the current state of the art and provides several illustrations of the use of monoclonal antibodies for the identification of T-lymphocyte phenotypes in fro/en section from cases of leprosy, mycosis fungoides, halo nevus, Kaposi's sarcoma, lichen planus and atopic dermatitis. Technical details and potential applications arc discussed. The growing availability of commercial immunostaining kits makes these techniques more accessible to the surgical pathologist; indeed a whole new range of truly specific, special stains are available, as pathologists we must simply learn to use them.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1983.tb00321.x
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  • 8
    Electronic Resource
    Electronic Resource
    Zeitler, Wolfgang Maria: Entscheidungsfreiheit bei Platon : Munich, C. H. Beck, 1983 (1984)
    Cambridge : Cambridge University Press
    The @classical review 34 (1984), S. 333-334 
    Details
    ISSN: 0009-840X
    Source: Cambridge Journals Digital Archives
    Topics: Classical Studies
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1017/S0009840X00104299
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  • 9
    Electronic Resource
    Electronic Resource
    Wieland, Wolfgang: Platon und die Formen des Wissens : Göttingen, Vandenhoeck & Ruprecht, 1982 (1983)
    Cambridge : Cambridge University Press
    The @classical review 33 (1983), S. 58-60 
    Details
    ISSN: 0009-840X
    Source: Cambridge Journals Digital Archives
    Topics: Classical Studies
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1017/S0009840X00101337
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  • 10
    Electronic Resource
    Electronic Resource
    Hubbard, B. A. F.; Karnofsky, E. S.: Plato's Protagoras. A Socratic Commentary : London, Duckworth, 1982 (1983)
    Cambridge : Cambridge University Press
    The @classical review 33 (1983), S. 332-333 
    Details
    ISSN: 0009-840X
    Source: Cambridge Journals Digital Archives
    Topics: Classical Studies
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1017/S0009840X00112387
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