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  • 2005-2009  (1)
  • 1990-1994  (2)
  • 1980-1984  (4)
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  • 1
    Electronic Resource
    Electronic Resource
    Review article: current management of primary sclerosing cholangitis (2005)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 21 (2005), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The management of primary sclerosing cholangitis (PSC) is hindered by incomplete understanding of the pathogenesis of the disease and the lack of good prognostic models. Few large randomized controlled trials of drug therapy have been published. Best practice in the management of PSC is currently based therefore on careful interpretation of the available evidence, close observation of individual patients and clinical experience of the disease. Drug therapy is useful for alleviating symptoms. Ursodeoxycholic acid may slow progression of the disease and reduce the frequency of complications. Consensus is emerging on the issues of screening for the malignant complications of PSC and the indications for liver transplantation are becoming broader and encompassing the earliest stages of cholangiocarcinoma. In view of the rarity of the disease in the general population, large international collaborations to study PSC are necessary to provide clearer answers in areas of uncertainty, and these are now beginning to emerge.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2005.02407.x
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  • 2
    Electronic Resource
    Electronic Resource
    Carcinoma of the gallbladder in ulcerative colitis and primary sclerosing cholangitis (1991)
    Springer
    Diseases of the colon & rectum 34 (1991), S. 827-828 
    Details
    ISSN: 1530-0358
    Keywords: Gallbladder ; Carcinoma ; Ulcerative colitis ; Primary sclerosing cholangitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The authors present the cases of two patients with carcinoma of the gallbladder complicating chronic ulcerative colitis. Both patients had concomitant primary sclerosing cholangitis. Twelve such cases of gallbladder carcinoma have been reported in the literature. The presence of primary sclerosing cholangitis in patients with ulcerative colitis is associated with malignancy of the extrahepatic biliary tree. It is suggested that, if colectomy is necessary, the liver should be biopsied and a cholecystectomy performed if the gallbladder is deemed abnormal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02051079
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The immunology of primary sclerosing cholangitis (1990)
    Springer
    Springer seminars in immunopathology 12 (1990), S. 121-128 
    Details
    ISSN: 1432-2196
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusion A number of recent studies have been discussed which provide strong evidence that genetic and immunological factors are important in the pathogenesis of PSC. Current evidence suggests that PSC is, like primary biliary cirrhosis, an immunologically mediated disease [8]. It seems likely that the immunological destruction of the biliary system is triggered in genetically predisposed individuals by viruses or bacteria [8]. The association with ulcerative colitis may be explained by the passage of viral or bacterial organisms across the damaged colonic epithelial barrier into the systemic circulation. Further studies are needed to confirm this attractive hypothesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00192687
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Hepatic iron stores and markers of iron overload in alcoholics and patients with idiopathic hemochromatosis (1982)
    Springer
    Digestive diseases and sciences 27 (1982), S. 909-916 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Liver iron concentrations were determined in 60 alcoholics with liver disease of varying severity, 15 patients with untreated idiopathic hemochromatosis, and 16 control subjects with biliary tract disease. Mean liver iron concentrations (μg/100 mg dry weight) were significantly greater in the alcoholics (156.4±7.8 (sem);P〈0.05) and in patients with idiopathic hemochromatosis (2094.5±230.7;P〈0.01) than in control subjects (53.0±7.0). Liver iron concentrations of 〉140 μg/100 mg were found in 17 alcoholics (29%) and in all 15 patients with idiopathic hemochromatosis. Liver iron concentrations 〉1000 μg/100 mg were found in all patients with idiopathic hemochromatosis but in none of the alcoholics. In the alcoholics no relationship existed between liver iron concentrations and the amount of alcohol consumed daily, the length of the drinking history, the amount of beverage iron consumed daily, or the severity of the liver disease. Serum ferritin concentrations reflected iron stores in patients with hemochromatosis and in alcoholics with minimal liver disease. However, in alcoholics with significant liver disease serum ferritin concentrations did not reflect iron stores accurately, although with normal values iron overload is unlikely. Serum iron concentration and percentage saturation of total iron-binding capacity were of little value in assessing iron status in either alcoholics or patients with hemochromatosis. Measurement of the liver iron concentration clearly differentiates between alcoholics with significant siderosis and patients with idiopathic hemochromatosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01316575
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Serum ferritin and binding of serum ferritin to concanavalin A as a tumor marker in patients with primary liver cell cancer and chronic liver disease (1982)
    Springer
    Digestive diseases and sciences 27 (1982), S. 111-116 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Total ferritin concentration was measured in sera of 30 patients with primary liver cell cancer (PLCC) and 33 patients with cirrhosis and compared with serum alpha-fetoprotein levels as a diagnostic marker of PLCC. Serum ferritin concentration was raised in 19 patients (63%) with PLCC and 11 patients (33%) with cirrhosis. The median level was significantly higher (P〈0.001) in the PLCC group (560 μg/liter) than in the cirrhotic group (137 μg/liter), although there was considerable overlap. Serum ferritin was posititively correlated with serum aminotransferase levels in the cirrhotic patients (r=0.53,P〈0.001), reflecting hepatic necrosis, but not in the PLCC patients. The concentration of ferritin binding to concanavalin A was measured in the sera of patients with elevated total serum ferritin. Although the proportion of bound ferritin was decreased in the majority of PLCC sera compared to controls (P〈0.001), there was overlap with the cirrhotic group, making it unlikely that this assay is useful in distinguishing a tumor-specific isoferritin. Serum alpha-fetoprotein levels were elevated in 21 patients (70%) with PLCC and proved to be a highly sensitive and specific test for PLCC. There was no relationship between the alpha-fetoprotein and serum ferritin concentrations. Serum ferritin is inferior to alpha-fetoprotein as an initial screening test for PLCC, but in alpha-fetoprotein-negative patients serum ferritin may have a role in monitoring therapy. Patients with cirrhosis with normal serum alpha-fetoprotein and ferritin concentrations are very unlikely to have PLCC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01311703
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Acute and chronic effects of alcohol on iron absorption (1983)
    Springer
    Digestive diseases and sciences 28 (1983), S. 321-327 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The absorption of nonheme59ferric chloride from a test meal was measured, using a whole-body counter, in 34 alcoholics with liver disease of varying severity, 30 of whom had normal hemoglobin values and four of whom were anemic. The results were compared with those obtained in five patients with iron-deficient anemia and nine healthy control subjects. There were no significant differences in mean percentage iron absorption (±sem) in the nonanemic alcoholic patients with fatty liver (14.6±3.7), alcoholic hepatitis (18.6±5.7), or cirrhosis (21.1±3.5) when compared with control subjects (22.0±2.5). Significantly increased mean percentage iron absorptions were seen, however, in the patients with iron-deficient anemia (64.8±5.6;P〈0.0001) and the alcoholics with anemia (60.7±7.8;P〈0.0001). There was an inverse relationship between iron absorption and serum ferritin concentration in the nonanemic alcoholics (r=−0.37;P〈0.025) but no correlation between iron absorption and liver iron concentration. The addition of absolute alcohol (0.5 g/kg body weight) to the test meal resulted in an increase in mean percentage iron absorption in eight control subjects (21.6±1.6 to 29.0±6.1) and in ten nonanemic alcoholics (15.8±3.2 to 20.0±3.8), although these differences did not achieve significance. Similarly when intravenous alcohol was given to four control subjects at the time of the test meal, iron absorption increased in all four so that the mean percentage iron absorption increased, although not significantly, from 17.6±2.7 to 39.3±9.5. Iron absorption in alcoholics does not differ significantly from normal. While the increased liver iron concentrations seen in approximately one third of alcoholics cannot be attributed to an increase in iron absorption as a result of chronic alcohol ingestion, further studies are needed to elucidate the acute effects of alcohol on iron absorption.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01324948
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  • 7
    Electronic Resource
    Electronic Resource
    Long-standing asymptomatic primary sclerosing cholangitis report of three cases (1981)
    Springer
    Digestive diseases and sciences 26 (1981), S. 778-782 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Three patients, two males and one female, with asymptomatic primary sclerosing cholangitis (PSC) are described. The diagnosis was made in each case by endoscopic retrograde cholangiography after investigation of persistent elevation of the serum alkaline phosphatase. All three have remained completely well without any medical or surgical treatment for 3, 7, and 15 years, respectively, despite extensive involvement of the biliary tree. Follow-up liver biopsies in two have shown no histological evidence of progression to secondary biliary cirrhosis. PSC may occur more frequently and may follow a less severe clinical course than previously recognized.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01309608
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