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  • 1
    Electronic Resource
    Electronic Resource
    Prelunularic acid, a probable immediate precursor of lunularic acid. First example of a "prearomatic" intermediate in the phenylpropanoid-polymalonate pathway (1983)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 105 (1983), S. 4480-4481 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00351a062
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  • 2
    Electronic Resource
    Electronic Resource
    A mutation (Trp1193→Leu1193) in the tyrosine kinase domain of the insulin receptor associated with type A syndrome of insulin resistance (1993)
    Springer
    Diabetologia 36 (1993), S. 414-422 
    Details
    ISSN: 1432-0428
    Keywords: Insulin receptor ; mutation ; tyrosine kinase activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We evaluated a 35-year-old diabetic male patient with type A insulin resistance, showing acanthosis nigricans. Insulin binding to the patient's Epstein-Barr-virus transformed lymphocytes was mildly reduced. The maximal insulin-stimulated autophosphorylation of the insulin receptor from the patient's transformed lymphocytes was decreased to 45% of that from the control subjects. On examination, the biological activities of insulin and insulin-like growth factor I in the patient's cultured fibroblasts, insulin sensitivity of amino isobutyric acid uptake and thymidine incorporation was decreased, but insulin-like growth factor I action was normal. The sequence analysis of amplified genomic DNA revealed that the patient was heterozygous for a mutation substituting Leu for Trp at codon 1193 in exon 20 of the insulin receptor gene. The patient's mother and sister were also heterozygous for a mutation in the insulin receptor gene that substituted Leu for Trp1193 in the Β subunit of the receptor. Therefore, the mutation causes insulin resistance in a dominant fashion. They were less hyperglycaemic and more hyperinsulinaemic than the proband after glucose loading. The mother had diabetes mellitus but did not show acanthosis nigricans, while the sister did not have diabetes and showed acanthosis nigricans. These results suggest that this mutation causes defective tyrosine kinase activity of the insulin receptor, which results in insulin resistance. Insulin action and phenotypic appearance may be mediated by different factors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00402277
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  • 3
    Electronic Resource
    Electronic Resource
    A highly predictable animal model of retinoblastoma (1982)
    Springer
    Acta neuropathologica 57 (1982), S. 203-208 
    Details
    ISSN: 1432-0533
    Keywords: Animal model ; Human adenovirus serotype 12 ; Retinal tumor cell line ; Syngeneic CDF rat ; T-antigen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A new animal model of retinoblastoma was developed in newborn inbred CDF rats by intravitreous inoculation of retinal tumor cells (5×104/5 μl) derived from the cultured tumor cell line EXP-5. The retinal tumor from which the cell line originated was induced by a single intravitreous inoculation of human adenovirus serotype 12 (5 μl of 108 TCID 50/0.1 ml) in syngeneic rats. Within 1 month after intravitreous moculation of EXP-5 cells, a clinically recognizable ocular tumor was obtained in all 39 rats. Ad 12-specific T-antigens were demonstrated in the cultured tumor cells using immunofluorescent techniques. Morphologically these tumor cells closely resembled retinoblastuma, with poorly differentiated intracytoplasmic organelles, solitary cilia with a 9+0 tubule pattern, and abnormal nuclear membrane associated with a set of basal bodies. The significance of this highly manipulable retinal tumor cell line is the capability of providing a full-fledged intravitreous tumor in 1-month-old CDF rats, whose actual life span is known to be 42 months. Transplantable retinal tumors described to date are reviewed breifly and compared with the presently reported cell line.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685390
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  • 4
    Electronic Resource
    Electronic Resource
    Semisynthesis and biological properties of the [B24-leucine]-, [B25-leucine]- and [B24-leucine, B25-leucine]-analogues of human insulin (1981)
    Springer
    Cellular and molecular life sciences 37 (1981), S. 811-813 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Trypsin-catalyzed coupling of porcine desoctapeptide-insulin with synthetic octapeptides produced the [LeuB24]-(I), [LeuB25]- (II) and [LeuB24, LeuB25]- (III)analogues of human insulin. I, II and III displayed respectively 20–30%, 1–2% and 0.5% of the receptor binding activity of the normal hormone. Biological activities of these analogues seemed to be proportional to their binding potencies when assayed in vitro, while in an in vivo assay analogue I was fully active and II exhibited 10–20% of normal activity. III was less active than II in all assays tested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01985653
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  • 5
    Electronic Resource
    Electronic Resource
    Short stature with normal growth hormone and elevated IGF-I (1992)
    Springer
    European journal of pediatrics 151 (1992), S. 321-325 
    Details
    ISSN: 1432-1076
    Keywords: Short stature ; Somatomedin-C ; IGF-I ; IGF-I resistance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report on a Japanese girl with short stature, malar hypoplasia, up-slanting palpebral fissures, blue sclerae and thin, stiff and slightly brownish hair. Short stature started in utero and her psychomotor development was normal. Menarche appeared at 13 years 8 months. Height at 14 years 5 months was 132 cm (−4.6 SD). Her growth hormone (GH) sleep pattern and responses to insulin,l-dopa, arginine, propranolol-glucagon and growth hormone-releasing hormone were normal. Plasma insulin-like growth factor I (IGF-I) was high (2170–4860 units/l) and increased from 4860 to 7080 units/l 20 h after biosynthetic GH injection. Gel infiltration patterns of the free and protein-bound IGF-I in plasma from the patient were not different from the controls; IGF-I fraction of the high and low molecular weight binding protein and the non-protein bound fraction were 75.5%, 15.8% and 8.7%, respectively. IGF-I from the patient showed normal bioactivities when determined by [35S]sulphate and [3H]thymidine uptake into cultured rat chondrocytes, and by [3H]thymidine and [3H]α-aminoisobutyric acid uptake into the patient's skin fibroblasts. IGF-I binding to cultured skin fibroblasts from the patient was comparable to that of controls. These results suggest that tissue specific defects of IGF-I receptors may be the cause of increased IGF-I levels in the patient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02113248
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  • 6
    Electronic Resource
    Electronic Resource
    Superplasticity of Fine TiC and TiN Dispersed Ti-6Al-4V Alloy Composites (1994)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 170-172 (Oct. 1994), p. 549-554 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/00/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.170-172.549.pdf
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  • 7
    Electronic Resource
    Electronic Resource
    Inactivation of T5 phage by cis-vaccenic acid, an antivirus substance from Rhodopseudomonas capsulata, and by unsaturated fatty acids and related alcohols (1991)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 77 (1991), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The antiviral extract from Rhodopseudomonas capsulata was purified and the predominant active component was defined as cis-vaccenic acid (C1- 8:1 Δ11) by gas-liquid chromatography and gas chromatography-mass spectrometry analyses. Antiviral activities of unsaturated fatty acids and related alcohols against T5 phage were also tested. Among them, linoelaidic acid, oleic acid, and petroselenyl alcohol inactivated 98%, 53%, 67% of T5 phage at the concentration of 50 μ g/ml, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.1991.tb04314.x
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  • 8
    Electronic Resource
    Electronic Resource
    Immunomodulatory effects on rainbow trout, Oncorlynchus mykiss, injected with the extract of abalone, Haliotis discus hannai (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of applied ichthyology 7 (1991), S. 0 
    Details
    ISSN: 1439-0426
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Rainbow trout, Oncorhynchus mykiss, injected with a water fraction extracted from abalone, Haliotis discus hannai, showed enhanced phagocytosis. This enhanced activity reached its maximum level 5 days after injection. The natural killer cell activities and the chemiluminescence responses of kidney leukocytes in fish treated with this fraction were also significantly increased, compared to those in albumin-treated fish. Rainbow trout injected intraperitoneally with this fraction showed an increased resistance to Vibrio anguillarum.〈section xml:id="abs1-2"〉〈title type="main"〉Zusammenfassung Immunomodulationseffekte bei Regenbogenforellen, Oncorhynchus mykiss, nach Injektion von Aba-lone-Entrakt, Haliotis discus hannaiBei Regenbogenforellen, Oncorynchus mykiss, denen ein wäßriger Extrakt der Abalone, Haliotis discus hannai, injiziert wurde, konnte eine gesteigerte Phagocytoseaktivität beobachtet werden. Diese Aktivi-tätssteigerung erreichte 5 Tage nach Verabreichung der Injektion ihr Maximum. Die natürliche Aktivi-tat von Killer-Zellen und die Chemoluminizenz-Reaktion der Nieren-Leukozyten in den mit dem Extrakt behandelten Fischen waren gegenüber Tieren, denen Albumin injiziert wurde, signifikant erhoht. Regenbogenforellen, denen der Abalone-Extrakt intraperitoneal injiziert wurde, zeigten eine erhohte Resistenz gegen Vibrio anguillarum.〈section xml:id="abs1-3"〉〈title type="main"〉Résumé Effects immunomodulatoires chez la truite arc-en-ciel, Onchorhynchus mykiss, traitie par des injections d'extraits d'onneaux, Haliotis discus hannai La truite arc-en-ciel, Onchorhynchus mykiss, traitie par injection d'une fraction aqueuse extraite d'ormeaux, Haliotis discus hannai, a montré une augmentation du taux de phagocytose. Cette augmentation de I'activité a atteint son niveau maximal cinq jours aprés injection. Les activitts naturelles des cellules tueuses et les résonses chimioluminescentes des leucocytes du rein des poissons traitis par cette fraction ont aussi significativement augmentis, par rapport ä celle des poissons traitis par de l'albumine. Les truites arc-en-ciel uaities par des injections intrapiritoniales de cette fraction ont montré une résistance accrue äVibrio anguillarum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1439-0426.1991.tb00594.x
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  • 9
    Electronic Resource
    Electronic Resource
    Influence of GaAs surface stoichiometry on the interface state density of as-grown epitaxial ZnSe/epitaxial GaAs heterostructures (1990)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 56 (1990), S. 1272-1274 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Epitaxial ZnSe/epitaxial GaAs interfaces have been formed by molecular beam expitaxy and evaluated by several techniques including capacitance-voltage measurements. In the study reported here, the GaAs surface stoichiometry was systematically varied prior to the nucleation of ZnSe. A dramatic reduction of interface state density occurred when the GaAs epilayer was made As deficient. The resulting interface state densities of as-grown structures are comparable to values obtained with (Al,Ga)As/GaAs interfaces.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.102534
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  • 10
    Electronic Resource
    Electronic Resource
    Changes in film structure and increase in coercivity for Co/Pd multilayered films with atmospheric annealing (1993)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 73 (1993), S. 334-338 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Co/Pd multilayered films exhibit large perpendicular magnetic anisotropy and have attracted attention as new materials for recording media and for other applications. The coercivity (Hc), however, is small in as-sputtered films. We have found that Hc increased markedly with the atmospheric annealing at 300 °C to 2 kOe, and studied the change in film structure and reason of the increase in Hc with the annealing. The rf magnetron sputtering method was employed in fabricating the films. Film structure changes were observed by x-ray diffraction, Auger electron spectroscopy, transmission electron microscopy, energy dispersive x-ray spectrography, and atomic force microscopy. The increase in Hc was observed only in the atmospheric annealing, and not in the vacuum-annealing. The internal structure of films after the atmospheric annealing at 300 °C consisted of columnar parts that had the multilayered structure that undertook vertical magnetization and column boundaries being surrounded by Co oxides. As a consequence, domain wall binding occurs in the segregated areas of the oxides in the column boundaries, thereby increasing Hc.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.353853
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