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  • 1
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Employing asymmetric Bragg reflection at the monochromator we obtain a wide and practically parallel synchrotron-radiation beam which, when combined with the use of a CCD detector, enables us to perform chemically specific, high-speed and high-resolution tomography. We present recent results obtained with this new method. The actual resolution achieved was determined from the measured line-spread function of the complete detection system which includes the CCD, the fluorescent screen, and the lens used for optical magnification. The modulation-transfer function (MTF) calculated from the line-spread function shows that with only twofold magnification and at 3% contrast detectability about 28 line pairs per mm are resolved. Extrapolating from this result we find that with an optical magnification of 7:1 about 100 line pairs per mm should be resolved. Ways to optimize the method further are discussed.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0584
    Keywords: HLA-class II ; Hematopoietic progenitor cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A panel of alloindifferent monoclonal antibodies (MAB's) was used in complement-dependent lysis to characterize human myeloid, erythroid and multipotential progenitors (CFU-GM, BFU-E, CFU-GEMM) for their expression of MHC class II HLA-DR, -DP, and -DQ products. 7–16 donors were tested in each system. MAB Tü 34, detecting DR products, caused reduction of CFU-GM by a mean of 89%, whereas BFU-E and CFU-GEMM were reduced by 67% and 66% respectively. 35% of CFU-GM, 27% of BFU-E and 32% of CFU-GEMM were lysed by MAB B7/21, recognizing HLA-DP determinants, while Tü 22, binding HLA-DQ antigens, lysed 32% only of CFU-GM and did not lyse the other progenitors. Employing the “broad” MAB Tü 39, which binds at least DR and DP, inhibition of colony formation by CFU-GM was generally greater than that caused by Tü 34 alone or even by combinations of Tü 34, Tü 22, and B7/21. This suggests that there may be a subset of DR−, DP−, DQ− hematopoietic progenitors, which nonetheless bind MAB Tü 39, previously proposed as a candidate for the recognition of novel class II antigens.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 21 (1942), S. 65-66 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-0584
    Keywords: Non-Hodgkin's lymphomas ; Chemotherapy ; Consolidation therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty four patients with high grade malignant NHL (stage II 8, stage III 4, stage IV 12 patients respectively) were treated with a response-oriented regimen: Treatment was initiated according to the CHOP-protocol. Patients achieving at least a partial remission after 2 and a complete remission (CR) after 4 cycles were continued on CHOP to a total of 9 cycles. Patients not meeting these criteria were switched to a combination of Etoposide, Ifosfamide, Methotrexate, and Bleomycin (VIM-Bleo). With CHOP treatment, 16 patients (67%) achieved a CR. Of the remaining 8, 7 were treated with VIM-Bleo; 5 of these entered CR for a overall CR rate of 21/24 (88%). With a median follow up of 28 months 7 patients relapsed: 6 relapses occurred in patients with a rapid initial response and treated only with CHOP. We conclude, that there is a significant risk of relapse even in patients readily responding to CHOP and that consolidation therapy with a non cross-resistant regimen may improve results in these patients.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 52 (1986), S. 305-315 
    ISSN: 1432-0584
    Keywords: T Cell Clones ; Myelopoiesis ; CFU-GM
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Regulatory effects of mixed lymphocyte culture (MLC)-derived CD4+ human T cell clones on granulocyte-macrophage colony (CFU-GM) formation by normal bone marrow (BM) were studied in an initial attempt to establish an in vitro model for the negative feedback control of myelopoiesis by alloactivated T cells. This is likely to be of clinical significance in the aberrant control of haematopoiesis during some cases of graft-versus-host disease (GVHD) after allogeneic BM transplantation. Whilst 5 such alloproliferative clones generally failed to suppress CFU-GM, the majority of clones with natural killer (NK)-like activity [10], or those with suppressive activity in MLC [2], regularly and strongly suppressed in this system, reinforcing the view that certain T cells may have potent negative regulatory effects on haematopoiesis.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Cancer chemotherapy and pharmacology 14 (1985), S. 279-281 
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A group of 46 patients with melphalan-resistant multiple myeloma was treated according to the M-2 protocol with melphalan, prednisolone, BCNU, cyclophosphamide, and vincristine. According to the Salmon and Durie classification, four patients had stage II A; 36, stage III A; and six, stage III B disease. Treatment resulted in five patients (11%) entering remission, while 21 (46%) had stable and 20 (43%) had progressive disease. The median survival for all patients was 12.5 months, patients in remission surviving longer (median 46 months) than those with stable disease (median 15.4 months) or progressive disease (median 6.9 months). Compared with other treatment regimens used in melphalan-resistant myeloma, the remission rate is low but the median survival exceeds that reported by most other authors.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 361 (1983), S. 653-655 
    ISSN: 1435-2451
    Keywords: Cervical biopsy ; Neurological complications ; Suitable anaesthesia ; Probeexcision im Halsbereich ; Neurologische Komplikationen ; Geeignete Anaesthesie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 433 Patienten mit Probeexcision im Bereich des Halses fanden sich neben Lymphadenitiden in erster Linie hämatologische Malignome und Metastasen maligner Tumoren. In 4,8 % traten behandlungsbedürftige Komplikationen auf, zum einen Wundheilungsstörungen (Hämatome, Entzündungen), zum zweiten neurologische Komplikationen des Nervus accessorius. Bei 4 Patienten bildeten sich diese vollständig zurück, einmal blieb eine Parese des Musculus deltoideus bestehen. Die Analyse des Krankengutes läßt erkennen, daß vor allem ungeeignete Narkoseverfahren (Lokalanaesthesie) bei in der Tiefe gelegenen, schlecht abgrenzbaren Tumoren zu Komplikationen geführt hatten.
    Notes: Summary In 433 cervical biopsies lymphadenitis, metastases of malignant tumors and of the haematologic system could be found first of all. In 4.8 % complications needed a further treatment, firstly trouble in wound healing (haematoma, inflammation), secondly neurological complications of the accessorial nerve. These complications receded in 4 patients completely, in one patient a paralysis of the deltoid muscle continued. The analysis of our patients suggested that unsuitable anaesthesia (local anaesthesia) for deeper-seated, badly demarked tumors is responsible for most of the complications.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 313 (1983), S. 189-195 
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The transfer of neutrons between low-lying states of Tin isotopes has been measured in the reaction120Sn→112Sn at energies below the Coulomb barrier. The transfer probabilities are deduced as function of the classical minimum distance from transfer and scattering cross sections at different angles and two energies. At the smallest distances very large transfer probabilities,p t =0.5, are observed for one- and two-neutron transfer. The two-neutron transfer is significantly enhanced as compared to a successive independent single-nucleon transfer. The definition of enhancement is discussed.
    Type of Medium: Electronic Resource
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