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  • 1
    Electronic Resource
    Electronic Resource
    Electroorganic chemistry. XIX. Anodic oxidation of nonconjugated dienes (1975)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 97 (1975), S. 4261-4264 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00848a019
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  • 2
    Electronic Resource
    Electronic Resource
    Sorption von Wasserdampf an Poly-S-carboxy-methyl-L-cystein und dem Natriumsalz (1978)
    Springer
    Colloid & polymer science 256 (1978), S. 391-391 
    Details
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01544400
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  • 3
    Electronic Resource
    Electronic Resource
    C cell (parafollicular cell) —Immunoreactive thyroglobulin: Purification, identification and immunological characterization (1979)
    Springer
    Histochemistry and cell biology 60 (1979), S. 155-168 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In relation to our earlier finding that the thyroglobulin-like material responsible for the cytochemical immunoreaction of C cells was obtained in the peak I fraction of Bio-Gel A-5 m, which included faster sedimenting components of thyroglobulin, the present study has identified the positive reacting component and clarified its immunochemical and immunohistochemical properties. 1. The peak I fraction of dog and hog thyroglobulin was chromatographed on a Bio-Gel A-50 m column. Antiserum to the faster eluted peak I 1 ′ only immunoreacted with C cells. The peak I 1 ′ was then refiltered on Bio-Gel A-150 m column. Antiserum to peak I 1 ″ fraction of both species which was eluted in the first part had high immune specificity for C cells. 2. When 4–30% and 2–16% continuous gradient gels of polyacrylamide were employed, peak I 1 ″ represented a single electrophoretic band corresponding to the component with the largest molecular weight in thyroglobulin. The protein was named C-thyroglobulin. The molecular weight was approximately 2,600,000, four times as large as 19 S, as calculated by relative mobility on the 2–16% gradient gel. 3. In double diffusion tests, anti-peak I 1 ″ antiserum produced two immunoprecipitin lines with its own antigen. The reaction was different from that of anti-19 S antiserum which formed a single line. 4. On immunoperoxidase staining, anti-peak I 1 ″ antiserum reacted to C cells in exactly the same way as anti-calcitonin antiserum. 5. When anti-peak I 1 ″ antiserum was absorbed with calcitonin, the subsequent reaction of the C cells was greatly decreased. The absorption of anticalcitonin antiserum with increased amounts of peak I 1 ″ abolished the C cell reaction. On the basis of these observations, the possibility that C-thyroglobulin is a biosynthetic precursor of calcitonin exists.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00495751
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  • 4
    Electronic Resource
    Electronic Resource
    Occurrence of immunoreactive thyroglobulin in the parafollicular cells of dogs (1977)
    Springer
    Cellular and molecular life sciences 33 (1977), S. 538-540 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary When the canine thyroid gland was stained by immunofluorescence and immunoperoxidase methods using undiluted thyroglobulin antiserum, a considerably stronger immunoreactivity was revealed in the parafollicular cells than in the colloid droplets and follicular cells. After induced hypercalcemia and antithyroid drug treatment, the immunoreactivity of the parafollicular cells coinciding with the movement of secretory granules containing calcitonin was conspicuously decreased. An application of diluted serum (above 1:10) produced a strong reaction in the colloid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01922259
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  • 5
    Electronic Resource
    Electronic Resource
    Spreading width of giant resonances and the attenuation of zero sound (1983)
    Springer
    The European physical journal 310 (1983), S. 223-227 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract It is shown that the RPA plus perturbation approach which is commonly used to calculate microscopically the spreading width of Giant Resonances is equivalent to Landau's suggestion that the damping width of zero sound at temperatureT=0 can be obtained by multiplying the classical collision result with an energyω- andT-dependent correction factor [1+(ω/2πkT)2] withT→0.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01415226
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  • 6
    Electronic Resource
    Electronic Resource
    Development and cytodifferentiation of C cell complexes in dog fetal thyroids (1980)
    Springer
    Cell & tissue research 206 (1980), S. 403-415 
    Details
    ISSN: 1432-0878
    Keywords: C cell complex ; Dog fetus ; C-thyroglobulin ; Calcitonin ; Immunoperoxidase reaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The development of C-cell complexes was investigated in dog fetuses by an immunoperoxidase method with three specific antisera: anti-calcitonin, anti-C-thyroglobulin (C-Tg), and anti-19S thyroglobulin. Ultimobranchial bodies joined with the thyroid anlage and then dispersed into the parenchyma to form large C cell groups. Sparse reaction products of C-Tg initially appeared in C cells with small amounts of cytoplasm. Later at about day 39 of gestation, when the immunoreactivity of calcitonin and 19S thyroglobulin appeared weakly in C cells and follicular cells, C-cell complexes were identified as large cell masses containing numerous undifferentiated cells without no immunoreactivity for any of the antisera. As development proceeded, the undifferentiated cells developed progressively the morphology of C cells. In addition, the undifferentiated cells developed 19S thyroglobulin immunoreactivity, that is, within some of the complexes small clusters of cells filled with material immunoreactive for 19S thyroglobulin. They were not organized into follicles during the fetal period, and were very slow in development. Depending on the degree of development of the undifferentiated cells, several features of the complexes were noted. The present study indicates that not only C cells but also follicular thyroid cells appear to be derived from the ultimobranchial bodies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237970
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  • 7
    Electronic Resource
    Electronic Resource
    Immunohistochemical study of a large molecular fragment of thyroglobulin in parafollicular cells (1978)
    Springer
    Cell & tissue research 187 (1978), S. 429-438 
    Details
    ISSN: 1432-0878
    Keywords: Parafollicular cells ; Thyroglobulin ; Larger molecular component ; Cross-reactivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Thyroglobulin-like immunoreactivity of the parafollicular cells was studied by an immunoperoxidase bridge technique using antisera against dog thyroglobulin fragments. 1. The dog parafollicular cells were specifically stained by anti-peak I (27S and larger components fraction) antiserum absorbed with peak II (19S fraction). By this method, they were easily distinguishable from the non-reactive follicular cells and colloid droplets. More sensitive staining of the parafollicular cells was possible with anti-peak I (larger components fraction) antiserum. The staining reactions indicated that the antigenic material responsible for immunoreactivity of the parafollicular cells was due to larger molecular components of thyroglobulin corresponding to 32S, 37S or 〉37S, and was not due to either the 19S thyroglobulin or to the 27S iodoprotein. 2. A conspicuous decrease of the immunoreactive material in the parafollicular cells occurred in the dog after both chronically induced hypercalcemia and antithyroid drug treatment. This coincided with movement of secretory granules containing calcitonin as shown by staining with silver impregnation, HCl-basic dye, and lead-hematoxylin. 3. The antisera against larger molecular components of dog thyroglobulin showed a high degree of cross-reactivity to the parafollicular cells of most of the mammalian species investigated; rats, rabbits, hamsters, mice, cats, lions, goats, cows, and human.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00229607
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  • 8
    Electronic Resource
    Electronic Resource
    Immunohistochemical study of the C-cell complex of dog thyroid glands with reference to the reactions of calcitonin, C-thyroglobulin and 19S thyroglobulin (1980)
    Springer
    Cell & tissue research 208 (1980), S. 405-415 
    Details
    ISSN: 1432-0878
    Keywords: C-cell complex ; Postnatal dog ; C-thyroglobulin ; Calcitonin ; 19S thyroglobulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Continued from the previous study in fetal animals (Kameda et al. 1980), the development and maturation of C-cell complexes in postnatal dogs from newborn to adult were investigated by use of an immunoperoxidase method using antisera to calcitonin, C-thyroglobulin (C-Tg) and 19S thyroglobulin, respectively. The younger the animals were, the more numerous were undifferentiated cells and high columnar epithelial cells in the complexes. With increasing age, the constituent elements of the complexes progressively differentiated. In one type of complex there are a large number of C-cells in various developmental stages, as well as undifferentiated cells and cysts. C-cell complexes composed mostly of mature C-cells were regarded as the more highly differentiated structures of this type. A second type contains follicular cells in various stages of differentiation in addition to undifferentiated cells and C-cells, i.e., 19S-positive cell masses not yet organized into follicles, primordial follicles with small lacunae and comparatively larger follicles. The follicular cells in the complexes were similar with respect to immunoreaction and folliculogenesis to the cells of fetal thyroids, but they developed very slowly. In conclusion, the present study indicates that follicular thyroid cells can differentiate within C-cell complexes, i.e., they develop from cells of ultimobranchial body origin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00233873
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  • 9
    Electronic Resource
    Electronic Resource
    Immunohistochemical reactions of C-cell complexes in dogs after induced hypercalcemia, antithyroid drug treatment and hypophysectomy (1980)
    Springer
    Cell & tissue research 208 (1980), S. 417-432 
    Details
    ISSN: 1432-0878
    Keywords: C-cell complex ; Immunoperoxidase reaction ; Hypercalcemia ; Antithyroid drug treatment ; Hypophysectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The C-cell complexes are remnants of ultimobranchial bodies retaining fetal characteristics. They contain C cells in various stages of differentiation, primordial follicles with small lacunae, follicular cell masses not yet forming follicles, and undifferentiated epithelial cells. By immunoperoxidase method using specific anti-calcitonin, anti-C-thyroglobulin and anti-19S thyroglobulin sera, the responses of C-cell complexes to hypercalcemia, thiourea, hypophysectomy and hypercalcemia after hypophysectomy were investigated systematically. These experimental conditions induced rapid differentiation and increased numbers of cells in the complexes. After chronic hypercalcemia, most of the complexes were occupied by mature C cells. The C cells in complexes similar to the cells in thyroid parenchyma presented increased mitotic activity, enlarged cell bodies and a marked decrease in materials immunoreactive for calcitonin and C-thyroglobulin. After prolonged administration of thiourea, follicular cell masses and small follicles, which underwent conspicuous hyperplasia and hypertrophy, markedly increased in the complexes and exceeded C cells in number. Typical undifferentiated cells were not recognized after hypercalcemia and treatment with thiourea, though they were unaffected by hypophysectomy. It is considered that undifferentiated cells develop into C cells after hypercalcemia and into follicular cells after treatment with thiourea; that is, undifferentiated cells seem to be the common precursor cell for both C cells and follicular cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00233874
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