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  • 1
    Digitale Medien
    Digitale Medien
    Effects of a new diuretic (piretanide) compared with furosemide on renal diluting and concentrating mechanisms in patients with the nephrotic syndrome (1980)
    Springer
    European journal of clinical pharmacology 17 (1980), S. 165-171 
    Details
    ISSN: 1432-1041
    Schlagwort(e): piretanide ; furosemide ; nephrotic syndrome ; loop diuretic ; natriuresis ; free water clearance
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The mode and site of action of the new diuretic agent piretanide were investigated in man. The effect of a single oral dose of 12 mg was compared with that of furosemide 80 mg p.o. in 6 patients with the nephrotic syndrome. Piretanide showed a greater diuretic and natriuretic response than furosemide during maximal water diuresis, but the effect was similar in the hydropenic state. Like furosemide, piretanide decreased free water clearance relative to delivery during water diuresis and the reabsorption of solute-free water during hydropenia. This inhibitory action on both the concentrating and diluting urinary mechanisms demonstrates an effect of piretanide localized in the ascending limb of Henle's loop. Consistent alterations in glomerular filtration rate, renal blood flow or filtration fraction were not observed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00561895
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  • 2
    Digitale Medien
    Digitale Medien
    Comparison of the short-term effects of the loop diuretic piretanide and furosemide in patients with renal insufficiency (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 413-418 
    Details
    ISSN: 1432-1041
    Schlagwort(e): piretanide ; furosemide ; renal insufficiency ; loop diuretic ; natriuresis ; pharmacokinetics ; diuretic effect ; kaliuresis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The natriuretic effect of the new loop diuretic piretanide was investigated in patients with severe renal insufficiency and was compared with that of furosemide. In the first study 4 hospitalized patients (serum creatinine 407 to 1220 µmol/l) were examined after administration of piretanide (12, 24, 48 and 96 mg to two patients, and 24, 48, 96 and 192 mg to 2 other subjects, given every third day). In the second study 6 hospitalized patients (serum creatinine 194 to 698 µmol/l) were studied after receiving orally 2 different doses of piretanide and 2 different doses of furosemide orally, given every fourth day. The mean natriuretic effect of 48 mg and 96 mg piretanide was 250 and 340% of the control value for the entire group, and 311 to 480% in the subgroup of patients with serum creatinine below 530 µmol/l. For a given dose the natriuresis was inversely correlated with renal function, and at a given serum creatinine level the natriuretic response was dose-dependent. The drug had less effect on water and potassium diuresis than on natriuresis. No significant difference in natriuretic effect was found on comparison with furosemide given in the ratio furosemide: piretanide 3.33:1. The pharmacokinetic data showed a direct correlation between the dose and the mean plasma concentration and also between urinary recovery of the drug and the measured natriuretic response.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00542133
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  • 3
    Digitale Medien
    Digitale Medien
    Pharmacokinetics of high doses of piretanide in moderate to severe renal failure (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 589-593 
    Details
    ISSN: 1432-1041
    Schlagwort(e): piretanide ; renal insufficiency ; furosemide ; pharmacokinetics ; loop diuretic
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The pharmacokinetics of piretanide was studied in 10 patients with chronic renal failure. After administration of a high oral dose (12 to 192 mg) of piretanide the kinetics behaved according to an open 2-compartment model. The elimination constant in the first phase (α) ranged from 0.385 to 0.756 h−1 and in the second phase (β) from 0.079 to 0.274 h−1. The corresponding elimination half-lives ranged from 55 to 108 min (t1/2 α) and from 152 to 524 min (t1/2 β). Only an average of 2.8% of the orally administered drug was recovered in 24 h urines. Nevertheless, a good correlation was found between urinary recovery or renal clearance of the drug and residual renal function. The elimination of piretanide by non-renal mechanisms appeared to be increased when renal function was greatly diminished.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00556897
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  • 4
    Digitale Medien
    Digitale Medien
    Das Verhalten von 16 Serumeiweißfraktionen nach Nierentransplantation (1978)
    Springer
    Journal of molecular medicine 56 (1978), S. 647-654 
    Details
    ISSN: 1432-1440
    Schlagwort(e): Serum proteins ; renal transplantation ; prelbumin ; immunoglobulins ; acute phase reaction ; Serumeiweiße ; Nierentransplantation ; Präalbumin ; Immunoglobuline ; Akutphasenproteine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Bei 20 nierentransplantierten Patienten mit stabiler Nierenfunktion wurden 16 Serumproteine systematisch untersucht. Dabei wurden folgende stark von der Norm abweichenden Befunde erhoben: eine konstante Erhöhung des Praealbumins und des sauren α1-Glykoproteins, des Haptoglobins, des Hämopexins und des β2-Glykoproteins sowie eine relativ häufige Erhöhung des α2-Makroglobulins. Es konnten keine Beziehungen zwischen den Serumeiweißveränderungen einerseits und den Grund- oder den Begleitkrankheiten, der Therapie oder der Dauer der Transplantation andererseits eruiert werden.
    Notizen: Summary We have investigated 16 serum proteins in 20 patients with stable renal function after renal transplantation. Our investigations have shown the following substantial findings: a regular increase of prealbumin, α1-glycoprotein, haptoglobin, hemopexin and β2-glycoprotein, as well as a rather frequent increase of α2-macroglobulin. As far as variations of the serum protein levels are concerned there was no correlation with kidney disease, accompanying illnesses, therapy or interval since transplantation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01477018
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