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  • 1980-1984  (2)
  • 1965-1969  (4)
  • 1
    Electronic Resource
    Electronic Resource
    Effect of Leucotrienes C4, D4, Prostacyclin and Thromboxane A2 on isolated human cerebral arteries (1982)
    Springer
    Acta neurochirurgica 62 (1982), S. 177-185 
    Details
    ISSN: 0942-0940
    Keywords: Prostaglandins (PG) ; subarachnoid haemorrhage (SAH)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of Leucotrienes C4 (LTC4), D4 (LTD4), Prostacyclin (PGI2) and Thromboxane A2 (TXA2) were studied on superfused human cerebral artery strips. LTC4 and LTD4 neither contracted nor relaxed the strips. PGI2 caused a dose-dependent relaxation from 0.2 nmol to 0.8 nmol. When given simultaneously with a vasoconstrictor substance, PGI2 had an almost complete inhibitory effect. TXA2 caused a dose-dependent contraction from 0.03 nmol to 0.15 nmol. Also, TXA2 was more potent than 5-Hydroxytryptamin (5-HT) and prostaglandin E2 (PGE2) with a contraction threshold of about 0.1 nmol. Prostaglandin E1 (PGE1), H2 (PGH2), and F2a (PGF2a) had contraction thresholds of about 1 nmol. Only a stable endoperoxide analogue (EPA), was more potent than TXA2, with a contraction threshold of 0.005 nmol. The possible role of these substances in producing ischaemic manifestations after subarachnoid haemorrhage (SAH) is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01403622
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Absolute Configuration of the Prostaglandins (1966)
    [s.l.] : Nature Publishing Group
    Nature 212 (1966), S. 38-39 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IT has been reported1 that the enzyme system which converts all-cis 8,11,14-eicosatrienoic acid into prostaglan-din E! (PGEJ also reacts with lids, 14cis-eicosadienoic acid yielding ll-hydroxy-12£rans,14c^s-eicosadienoic acid (I). A small amount of this acid has now been prepared by ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/212038a0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Prostaglandins (1965)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biochemistry 34 (1965), S. 101-108 
    Details
    ISSN: 0066-4154
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Chemistry and Pharmacology , Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.bi.34.070165.000533
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Localization and characteristics of transglutaminase in the rabbit and human eye (1982)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 218 (1982), S. 233-236 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Transglutaminases (transamidases; endo-γ-gluta-mine: ε-lysine transferases) are calcium-dependent enzymes, which cross-link proteins by introducing covalent ε-(γ-gluta-minyl)lysine pseudopeptide bonds between the molecules. The distribution and characteristics of transglutaminase in both human and rabbit eyes have been studied. Transglutaminase activity was measured with an isotope technique based on the enzyme catalysed incorporation of14C-putrescine into casein. Electrophoretic characteristics were studied using agarose gel electrophoresis combined with a specific fluorescent activity staining procedure based on the transglutaminase catalysed incorporation of monodansylthiacadaverine into casein. A thrombin-independent enzyme, indistinguishable from the guinea pig liver transglutaminase with regard to electrophoretic mobility, was found in the choroid/pigment epithelium and ciliary body of the human eye while the lens, retina, iris and vitreous humour did not contain detectable amounts. The lens and the choroid/pigment epithelium of the rabbit eye tissues contained high activities while the activity in the extract from the combined ciliary body/iris was low but measurable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02175888
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Die Prostaglandine (1965)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 77 (1965), S. 445-452 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Prostaglandine, die in vielen Geweben zahlreicher Tierarten vorkommen, sind lipoidlösliche C20-Carbonsäuren. Sie enthalten einen fünfgliedrigen Ring, eine Oxo- und zwei Hydroxygruppen (oder drei Hydroxygruppen), außerdem eine bis drei Doppelbindungen. Die Strukturaufklärung gelang durch eine Kombination chemischer, radiochemischer und physikalischer Methoden mit Gaschromatographie und Massenspektrometrie. Im Organismus bilden sich die Prostaglandine aus essentiellen Fettsäuren. Die Prostaglandine stimulieren die glatte Muskulatur und wirken auf den Fettstoffwechsel ein.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19650771003
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    The Prostaglandins (1965)
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 4 (1965), S. 410-416 
    Details
    ISSN: 0570-0833
    Keywords: Prostaglandins ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Prostaglandins occur in many animal species and tissues. They are C20-carboxylic acids contining one five-membered ring, one keto group, two or three hydroxy groups, and one to three C=C double bonds. Their structures were elucidated by chemical, radiochemical, and physical methods in combination with gas chromatography and mass spectrometry. The prostaglandins are biosynthesized from essential fatty acids. By their action smooth muscles are stimulated and lipid metabolism is affected.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/anie.196504101
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    Paper (German National Licenses)
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