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  • 1980-1984  (7)
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  • 1
    Electronic Resource
    Electronic Resource
    Neurochemical Studies of the Mesolimbic Dopaminergic Pathway: [3H]Spiperone Labels Two Binding Sites in Homogenates of the Nucleus Accumbens of Rat Brain (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 39 (1982), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The binding of [3H]spiperone to membranes of the nucleus accumbens of the rat brain was studied in vitro and found to be of high affinity, rapid, saturable, reversible and stereospecific. Dissociation and saturation experiments indicated the presence of two specific binding sites with apparent dissociation constants of 70 pM and 〉1 nM. Specific binding with 25 pM [3H]spiperone represented 〉90% of total binding and was displaced by dopaminergic agonists, neuroleptic drugs and ergot derivatives. The rank order of potency for the ergot derivatives was bromocryptine 〉 pergolide 〉 lergo-trile, and that for D-2 antagonists was domperidone 〉 sulpiride 〉 molindone 〉 metoclopramide. Noradrenergic, histaminergic and serotonergic components of the binding were not detected. [3H]Spiperone binds to high-affinity sites in homogenates of nucleus accumbens, which are likely to be D-2 receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1982.tb12591.x
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  • 2
    Electronic Resource
    Electronic Resource
    [3H]Spiperone Labels Non-Cyclase-Linked Dopamine Receptors in the Ventral Tegmental Area of Rat Brain (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 39 (1982), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The binding of [3H]spiperone, a neuroleptic/dopamine receptor ligand, to membranes of the ventral tegmental area of the rat was studied in vitro and found to be rapid, saturable, reversible, and of high affinity. Specific binding was displaced by the dopaminergic agonists dopamine, apomorphine, and 2-amino-6,7-dihydroxytetralin, and stereospecifically by the neuroleptic drugs butaclamol and flupenthixol. Bromocryptine and other ergots displaced the binding, as did the D-2 antagonists domperidone, molindone, metoclopramide, and sulpiride. Noradrenergic, histaminergic, and serotonergic components of the binding were not detected in displacement studies with various agonists and antagonists. These data are consistent with the hypothesis that [3H]spiperone labels dopamine receptors in the ventral tegmental area that are not linked to adenylate cyclase and are therefore likely to be of the D-2 type.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1982.tb07978.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Neurochemical Studies of the Mesolimbic Dopaminergic Pathway: Glycinergic Mechanisms and Glycinergic-Dopaminergic Interactions in the Rat Ventral Tegmentum (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 38 (1982), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The rat ventral tegmentum (containing somata and dendrites of mesolimbic dopaminergic neurones) contained 1.3 μmnol/g wet weight of glycine. Slices of ventral tegmentum accumulated exogenous [3H]glycine by an energy-, temperature- and sodium-dependent mechanism. The uptake was mediated by two different transport systems; one system with relatively low affinity for glycine (Km∼400 μm) and the other a higher affinity for glycine (Km∼ 10 μm). Small amino acid analogues of glycine inhibited the uptake process, the most potent being taurine and β-alanine (47% and 44% inhibition, respectively, at 1 mm). Release of exogenous [3H]glycine by elevated potassium and by protoveratrine A was calcium-dependent and tetrodotoxin-sensitive. Glycine (500 μm-2 mm) potentiated the protoveratrine A-induced release of exogenous [3H]dopamine from slices of ventral tegmentum; this potentiation was blocked by strychnine (10 μm). A convulsant dose of strychnine elevated the concentration of 3,4-dihydroxyphenylacetic acid in the ventral tegmentum. Glycine is likely to be a transmitter in the ventral tegmentum and to have a role regulating the activity of somatodendritic regions of mesolimbic dopaminergic neurones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1982.tb08665.x
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  • 4
    Electronic Resource
    Electronic Resource
    Neurochemical Studies of the Mesolimbic Dopaminergic Pathway: Somatodendritic Mechanisms and GABAergic Neurones in the Rat Ventral Tegmentum (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 34 (1980), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The rat ventral tegmentum (containing dendrites and somata of mesolimbic neurones) contained 1.3 μg/g of dopamine, which was reduced to 40% of the control level by reserpine. Slices of ventral tegmentum were able to accumulate and release (elevated potassium or protoveratrine A) exogenous [3H]dopamine. In parallel studies the uptake mechanism in ventral tegmentum was shown to be virtually identical to the nerve terminal uptake of [3H]dopamine by slices of nucleus accumbens. The release of [3H]dopamine was indistinguishable from that observed in substantia nigra, where there is substantial evidence for dendritic mechanisms. Basal adenylate cyclase activity was present, but dopamine-stimulated activity was not detected. A high GABA concentration (7.7 μmol/g) was present in ventral tegmentum, in conjunction with an uptake and a release mechanism for [3H]GABA. GABA and muscimol elicited a small, reproducible efflux of [3H]dopamine, but an interaction between dopamine and [3H]GABA efflux was not observed. The results are in accord with transmitter roles for dopamine and GABA in the somatoden-dritic area of mesolimbic dopaminergic neurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1980.tb11253.x
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  • 5
    Electronic Resource
    Electronic Resource
    ADRENALINE DEPLETION IN THE HYPOTHALAMUS OF THE RAT AFTER CHRONIC α-METHYLDOPA (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 8 (1981), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Individual anterior hypothalamic-preoptic nuclei were dissected from the brains of control and α-methyldopa treated (2 × 40 mg/kg, 5 days) rats, and the concentrations of adrenaline and other catecholamines were estimated.2. By a combination of radioenzymatic assay and paper chromatography the concentrations of adrenaline, noradrenaline, dopamine, α-methylnoradrenaline and α-methyldopamine were determined concurrently in the same sample.3. α-Methyldopa reduced the adrenaline levels of the hypothalamic nuclei by 47–68% of control concentrations.4. A differential displacement of the parent catecholamines was observed and the depletions were ranked: adrenaline 〈 dopamine 〈 noradrenaline.5. α-Methylnoradrenaline and α-methyldopamine were found in all hypothalamic nuclei.6. The depletion of hypothalamic adrenaline by α-methyldopa could represent a pharmacological mechanism contributing to the antihypertensive action of the drug.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1981.tb00130.x
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of muscimol on dopamine metabolism of the rat hypothalamus (1980)
    Springer
    Cellular and molecular life sciences 36 (1980), S. 1312-1313 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Muscimol, a potent GABA receptor agonist, produced increases in DOPAC and dopamine concentrations in the rat hypothalamus. GABAergic receptors, therefore, modulate hypothalamic dopaminergic neurones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01969608
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  • 7
    Electronic Resource
    Electronic Resource
    Differential effects of IV and IP muscimol on central dopamine metabolism (1981)
    Springer
    Psychopharmacology 74 (1981), S. 71-73 
    Details
    ISSN: 1432-2072
    Keywords: Muscimol ; Dopamine ; DOPAC ; Nigrostriatal ; Mesolimbic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of IV and IP muscimol on the concentrations of dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) in both the nigrostriata) and mesolimbic dopaminergic pathways has been studied. IV muscimol (2 mg/kg), produced significant decreases in the concentration of DA in both DA systems, while the concentration of DOPAC remained unaltered. However, IP muscimol (5 and 10 mg/kg) caused significant increases in the concentrations of DA or DOPAC in all brain regions examined. Our results suggest differential actions of muscimol on DA metabolism dependent upon the route of administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431760
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